Protein : Qrob_P0527500.2 Q. robur
Protein Identifier  ? Qrob_P0527500.2 Organism . Name  Quercus robur
Score  94.3 Score Type  egn
Protein Description  (M=3) 3.2.1.167 - Baicalin-beta-D-glucuronidase. Code Enzyme  EC:3.2.1.31, EC:3.2.1.167
Gene Prediction Quality  validated Protein length 

Sequence

Length: 560  
Kegg Orthology  K07964
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0016798 hydrolase activity, acting on glycosyl bonds Catalysis of the hydrolysis of any glycosyl bond.
GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.

24 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|tcc:TCM_038194 1 559 + 559 Gaps:46 89.92 615 75.23 0.0 Glucuronidase 3 isoform 1
blastp_kegg lcl|vvi:100255842 1 559 + 559 Gaps:48 99.28 559 74.59 0.0 heparanase-like protein 3-like
blastp_kegg lcl|cmo:103496979 1 559 + 559 Gaps:33 100.00 538 73.61 0.0 heparanase-like protein 3
blastp_kegg lcl|pop:POPTR_0025s00410g 4 558 + 555 Gaps:41 99.09 547 73.80 0.0 hypothetical protein
blastp_kegg lcl|pmum:103341177 1 559 + 559 Gaps:35 100.00 542 71.77 0.0 heparanase-like protein 3
blastp_kegg lcl|csv:101224772 1 559 + 559 Gaps:34 100.00 539 74.21 0.0 heparanase-like protein 3-like
blastp_kegg lcl|csv:101213905 1 559 + 559 Gaps:34 100.00 539 74.21 0.0 heparanase-like protein 3-like
blastp_kegg lcl|cic:CICLE_v10007919mg 1 558 + 558 Gaps:40 99.82 547 73.26 0.0 hypothetical protein
blastp_kegg lcl|cit:102610770 1 558 + 558 Gaps:40 99.82 547 73.26 0.0 heparanase-like protein 3-like
blastp_kegg lcl|pxb:103949167 1 559 + 559 Gaps:37 100.00 542 71.40 0.0 heparanase-like protein 3
blastp_pdb 3vo0_A 140 409 + 270 Gaps:36 53.69 488 24.81 7e-07 mol:protein length:488 beta-Glucuronidase
blastp_pdb 3vnz_A 140 409 + 270 Gaps:36 53.69 488 24.81 7e-07 mol:protein length:488 beta-GLUCURONIDASE
blastp_pdb 3vny_A 140 409 + 270 Gaps:36 53.69 488 24.81 7e-07 mol:protein length:488 beta-GLUCURONIDASE
blastp_uniprot_sprot sp|Q9FZP1|HPSE3_ARATH 7 558 + 552 Gaps:30 98.88 536 65.85 0.0 Heparanase-like protein 3 OS Arabidopsis thaliana GN At5g34940 PE 2 SV 2
blastp_uniprot_sprot sp|Q8L608|HPSE2_ARATH 10 558 + 549 Gaps:42 98.89 539 46.90 2e-170 Heparanase-like protein 2 OS Arabidopsis thaliana GN At5g61250 PE 2 SV 1
blastp_uniprot_sprot sp|Q9FF10|HPSE1_ARATH 1 558 + 558 Gaps:38 99.82 543 45.94 1e-164 Heparanase-like protein 1 OS Arabidopsis thaliana GN At5g07830 PE 2 SV 1
blastp_uniprot_sprot sp|Q9LRC8|BAGLU_SCUBA 1 551 + 551 Gaps:70 97.34 527 46.59 3e-152 Baicalin-beta-D-glucuronidase OS Scutellaria baicalensis GN SGUS PE 1 SV 1
blastp_uniprot_sprot sp|Q9Y251|HPSE_HUMAN 140 558 + 419 Gaps:69 68.51 543 33.60 4e-31 Heparanase OS Homo sapiens GN HPSE PE 1 SV 2
blastp_uniprot_sprot sp|Q90YK5|HPSE_CHICK 140 558 + 419 Gaps:64 71.32 523 30.56 8e-31 Heparanase OS Gallus gallus GN HPSE PE 1 SV 1
blastp_uniprot_sprot sp|Q9MYY0|HPSE_BOVIN 94 558 + 465 Gaps:87 74.13 545 32.92 4e-30 Heparanase OS Bos taurus GN HPSE PE 2 SV 2
blastp_uniprot_sprot sp|Q6YGZ1|HPSE_MOUSE 78 558 + 481 Gaps:107 87.48 535 30.13 2e-28 Heparanase OS Mus musculus GN Hpse PE 1 SV 3
blastp_uniprot_sprot sp|Q71RP1|HPSE_RAT 78 558 + 481 Gaps:101 87.31 536 29.91 2e-27 Heparanase OS Rattus norvegicus GN Hpse PE 2 SV 1
blastp_uniprot_sprot sp|Q8WWQ2|HPSE2_HUMAN 140 559 + 420 Gaps:85 64.70 592 28.98 2e-18 Inactive heparanase-2 OS Homo sapiens GN HPSE2 PE 1 SV 3
rpsblast_cdd gnl|CDD|190706 30 346 + 317 Gaps:1 99.38 320 67.61 1e-165 pfam03662 Glyco_hydro_79n Glycosyl hydrolase family 79 N-terminal domain. Family of endo-beta-N-glucuronidase or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly insolubility and barrier properties of basement membranes and extracellular matrices. Hence cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity.

14 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 1 6 6 SIGNAL_PEPTIDE_N_REGION none N-terminal region of a signal peptide. none
Phobius 27 559 533 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 7 18 12 SIGNAL_PEPTIDE_H_REGION none Hydrophobic region of a signal peptide. none
PANTHER 436 456 21 PTHR14363:SF11 none none none
Pfam 30 346 317 PF03662 none Glycosyl hydrolase family 79, N-terminal domain IPR005199
Phobius 1 26 26 SIGNAL_PEPTIDE none Signal peptide region none
PANTHER 478 559 82 PTHR14363:SF11 none none none
PANTHER 10 415 406 PTHR14363:SF11 none none none
PANTHER 436 456 21 PTHR14363 none none IPR005199
PANTHER 10 415 406 PTHR14363 none none IPR005199
Phobius 19 26 8 SIGNAL_PEPTIDE_C_REGION none C-terminal region of a signal peptide. none
Gene3D 140 340 201 G3DSA:3.20.20.80 none none IPR013781
PANTHER 478 559 82 PTHR14363 none none IPR005199
SUPERFAMILY 44 390 347 SSF51445 none none IPR017853

2 Localization

Analysis Start End Length
TMHMM 5 24 19
SignalP_EUK 1 18 17

0 Qtllist

0 Targeting