Protein : Qrob_P0522760.2 Q. robur
Protein Identifier  ? Qrob_P0522760.2 Organism . Name  Quercus robur
Score  98.1 Score Type  egn
Protein Description  (M=1) K14773 - U3 small nucleolar RNA-associated protein 23 Gene Prediction Quality  validated
Protein length 

Sequence

Length: 260  
Kegg Orthology  K14773
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0 Synonyms

1 GO Terms

Identifier Name Description
GO:0032040 small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

28 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100251430 1 254 + 254 Gaps:1 89.79 284 68.63 2e-121 rRNA-processing protein UTP23 homolog-like
blastp_kegg lcl|gmx:100778980 1 252 + 252 Gaps:5 89.47 285 65.49 4e-114 rRNA-processing protein UTP23 homolog
blastp_kegg lcl|sot:102593911 1 238 + 238 Gaps:2 83.80 284 67.23 3e-113 rRNA-processing protein UTP23 homolog
blastp_kegg lcl|gmx:100806716 1 252 + 252 Gaps:5 89.47 285 63.53 7e-113 rRNA-processing protein UTP23 homolog
blastp_kegg lcl|cit:102627801 1 259 + 259 Gaps:1 92.20 282 63.85 2e-112 rRNA-processing protein UTP23 homolog
blastp_kegg lcl|cit:102628095 1 249 + 249 Gaps:1 87.72 285 65.60 9e-112 rRNA-processing protein UTP23 homolog
blastp_kegg lcl|cic:CICLE_v10016162mg 1 249 + 249 Gaps:1 87.72 285 65.60 9e-112 hypothetical protein
blastp_kegg lcl|pxb:103927270 1 246 + 246 Gaps:4 87.41 286 65.20 1e-111 rRNA-processing protein UTP23 homolog
blastp_kegg lcl|pop:POPTR_0004s20810g 1 249 + 249 Gaps:3 87.63 283 62.90 1e-110 hypothetical protein
blastp_kegg lcl|mdm:103417427 1 246 + 246 Gaps:4 87.72 285 65.60 1e-110 rRNA-processing protein UTP23 homolog
blastp_uniprot_sprot sp|O74862|UTP23_SCHPO 1 250 + 250 Gaps:25 92.69 260 36.51 5e-31 rRNA-processing protein utp23 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN utp23 PE 3 SV 1
blastp_uniprot_sprot sp|Q9BRU9|UTP23_HUMAN 1 243 + 243 Gaps:42 84.74 249 34.12 9e-25 rRNA-processing protein UTP23 homolog OS Homo sapiens GN UTP23 PE 1 SV 2
blastp_uniprot_sprot sp|Q08DU1|UTP23_BOVIN 1 246 + 246 Gaps:44 87.10 248 35.19 3e-23 rRNA-processing protein UTP23 homolog OS Bos taurus GN UTP23 PE 2 SV 1
blastp_uniprot_sprot sp|Q9CX11|UTP23_MOUSE 1 166 + 166 Gaps:10 66.67 249 32.53 3e-21 rRNA-processing protein UTP23 homolog OS Mus musculus GN Utp23 PE 2 SV 1
blastp_uniprot_sprot sp|Q12339|UTP23_YEAST 1 167 + 167 Gaps:7 66.14 254 32.14 3e-19 rRNA-processing protein UTP23 OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN UTP23 PE 1 SV 1
blastp_uniprot_sprot sp|Q55GM5|FCF1_DICDI 2 139 + 138 Gaps:16 75.26 194 29.45 1e-10 rRNA-processing protein FCF1 homolog OS Dictyostelium discoideum GN fcf1 PE 3 SV 1
blastp_uniprot_sprot sp|Q5RFQ0|FCF1_PONAB 25 139 + 115 Gaps:6 57.07 198 30.97 7e-08 rRNA-processing protein FCF1 homolog OS Pongo abelii GN FCF1 PE 2 SV 1
blastp_uniprot_sprot sp|Q9Y324|FCF1_HUMAN 25 139 + 115 Gaps:6 57.07 198 30.97 7e-08 rRNA-processing protein FCF1 homolog OS Homo sapiens GN FCF1 PE 2 SV 1
blastp_uniprot_sprot sp|Q32PD0|FCF1_BOVIN 25 139 + 115 Gaps:6 57.07 198 30.97 7e-08 rRNA-processing protein FCF1 homolog OS Bos taurus GN FCF1 PE 2 SV 1
blastp_uniprot_sprot sp|Q05498|FCF1_YEAST 12 138 + 127 Gaps:6 66.14 189 28.00 1e-07 rRNA-processing protein FCF1 OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN FCF1 PE 1 SV 1
rpsblast_cdd gnl|CDD|189036 2 148 + 147 Gaps:2 100.00 147 47.62 2e-54 cd09866 PIN_Fcf1-Utp23-H PIN domain of rRNA-processing protein Fcf1- and Utp23-like homologs found in eukaryotes except fungi. PIN domain homologs of Fcf1/Utp24 (FAF1-copurifying factor 1/U three-associated protein 24) and Utp23 essential proteins involved in pre-rRNA processing and 40S ribosomal subunit assembly are included in this subfamily. Fcf1 is a component of the small subunit (SSU) processome and an essential nucleolar protein required for processing of the 18S pre-rRNA at sites A0-A2. These PIN (PilT N terminus) domains are homologs of flap endonuclease-1 (FEN1)-like PIN domains but apparently lack the H3TH domain or extensive arch/clamp region seen in the latter. PIN domains typically contain three or four conserved acidic residues (putative metal-binding active site residues). The Fcf1-Utp23 homolog PIN domain subfamily has three of these conserved acidic residues rather than the four seen in the Fcf1 PIN domain subfamily.
rpsblast_cdd gnl|CDD|191123 52 150 + 99 Gaps:5 99.01 101 43.00 3e-23 pfam04900 Fcf1 Fcf1. Fcf1 is a nucleolar protein involved in pre-rRNA processing. Depletion of yeast Fcf1 and Fcf2 leads to a decrease in synthesis of the 18S rRNA and results in a deficit in 40S ribosomal subunits.
rpsblast_cdd gnl|CDD|189021 28 148 + 121 Gaps:1 100.00 120 38.33 2e-20 cd08553 PIN_Fcf1-like PIN domain of rRNA-processing proteins Fcf1 (Utp24 YDR339C) Utp23 (YOR004W) and other eukaryotic homologs. Fcf1 (FAF1-copurifying factor 1 also known as Utp24) and Utp23 (U three-associated protein 23) are essential proteins involved in pre-rRNA processing and 40S ribosomal subunit assembly. Components of the small subunit (SSU) processome Fcf1 and Utp23 are essential nucleolar proteins that are required for processing of the 18S pre-rRNA at sites A0-A2. The Fcf1 protein was reported to interact with Pmc1p (vacuolar Ca2+ ATPase) and Cor1p (core subunit of the ubiquinol-cytochrome c reductase complex). The PIN (PilT N terminus) domains of these proteins are homologs of flap endonuclease-1 (FEN1)-like PIN domains but apparently lack the H3TH domain or extensive arch/clamp region seen in the latter. PIN domains typically contain three or four conserved acidic residues (putative metal-binding active site residues). The Fcf1 PIN domain subfamily has four of these putative active site residues. Point mutation studies showed that the conserved acidic residues in the putative active site of Saccharomyces cerevisiae Fcf1 are essential for pre-rRNA processing at sites A1 and A2 whereas the presence of the Fcf1 protein itself is also required for cleavage at site A0. S. cerevisiae Utp23 lacks several of these key residues and mutation of the conserved acidic residues seen in Utp23 did not interfere with rRNA maturation and cell viability. The subfamily of Fcf1- and Utp23-like homologs found in eukaryotes (except fungi) posses three of the four conserved residues seen in S. cerevisiae Fcf1.
rpsblast_cdd gnl|CDD|189035 4 148 + 145 Gaps:5 100.00 148 33.11 3e-20 cd09865 PIN_Utp23 PIN domain of rRNA-processing protein Utp23 (YOR004W) and other fungal homologs. Saccharomyces cerevisiae Utp23 (U three-associated protein 23) component of the small subunit (SSU) processome is an essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. The PIN (PilT N terminus) domain of this protein is a homolog of flap endonuclease-1 (FEN1)-like PIN domains but apparently lack the H3TH domain or extensive arch/clamp region seen in the latter. PIN domains typically contain three or four conserved acidic residues (putative metal-binding active site residues. S. cerevisiae Utp23 lacks several of these key residues and mutation of the conserved acidic residues seen in Utp23 did not interfere with rRNA maturation and cell viability.
rpsblast_cdd gnl|CDD|31602 16 151 + 136 Gaps:9 99.26 136 31.11 3e-12 COG1412 COG1412 Uncharacterized proteins of PilT N-term./Vapc superfamily [General function prediction only].
rpsblast_cdd gnl|CDD|189034 25 148 + 124 Gaps:14 85.31 143 31.97 1e-10 cd09864 PIN_Fcf1 PIN domain of rRNA-processing protein Fcf1 (Utp24 YDR339C) and other eukaryotic homologs. Fcf1/Utp24 (FAF1-copurifying factor 1/U three-associated protein 24) is an essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. Component of the small subunit (SSU) processome Fcf1 is an essential nucleolar protein that is required for processing of the 18S pre-rRNA at sites A0-A2. The Fcf1 protein was reported to interact with Pmc1p (vacuolar Ca2+ ATPase) and Cor1p (core subunit of the ubiquinol-cytochrome c reductase complex). The PIN (PilT N terminus) domain of this protein is a homolog of flap endonuclease-1 (FEN1)-like PIN domains but apparently lack the H3TH domain or extensive arch/clamp region seen in the latter. PIN domains typically contain three or four conserved acidic residues (putative metal-binding active site residues). The Fcf1 PIN domain subfamily has four of these putative active site residues and the Fcf1-Utp23 homolog PIN domain subfamily has three of them. Point mutation studies of the conserved acidic residues in the putative active site of Saccharomyces cerevisiae Fcf1 determined they were essential for pre-rRNA processing at sites A1 and A2 whereas the presence of the Fcf1 protein itself is also required for cleavage at site A0.
rpsblast_kog gnl|CDD|38374 1 252 + 252 Gaps:32 93.22 236 37.73 3e-44 KOG3164 KOG3164 KOG3164 Uncharacterized proteins of PilT N-term./Vapc superfamily [General function prediction only].
rpsblast_kog gnl|CDD|38375 23 148 + 126 Gaps:6 63.59 195 30.65 7e-10 KOG3165 KOG3165 KOG3165 Predicted nucleic-acid-binding protein contains PIN domain [General function prediction only].

5 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Pfam 52 150 99 PF04900 none Fcf1 IPR006984
SUPERFAMILY 25 150 126 SSF88723 none none IPR029060
Gene3D 25 149 125 G3DSA:3.40.50.1010 none none IPR029060
PANTHER 1 170 170 PTHR12416 none none none
PANTHER 201 244 44 PTHR12416 none none none

0 Localization

0 Qtllist

0 Targeting