Protein : Qrob_P0522600.2 Q. robur
Protein Identifier  ? Qrob_P0522600.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=3) 3.5.4.19 - Phosphoribosyl-AMP cyclohydrolase. Code Enzyme  EC:3.6.1.31, EC:3.5.4.19
Gene Prediction Quality  validated Protein length 

Sequence

Length: 251  
Kegg Orthology  K11755
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
GO:0004636 phosphoribosyl-ATP diphosphatase activity Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+).
GO:0004635 phosphoribosyl-AMP cyclohydrolase activity Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide.

33 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|cam:101489383 26 249 + 224 Gaps:8 75.08 309 75.86 9e-123 histidine biosynthesis bifunctional protein hisIE chloroplastic-like
blastp_kegg lcl|pvu:PHAVU_001G082700g 21 249 + 229 Gaps:17 86.83 281 73.36 7e-120 hypothetical protein
blastp_kegg lcl|pper:PRUPE_ppa009521mg 26 249 + 224 Gaps:8 80.28 289 74.14 4e-119 hypothetical protein
blastp_kegg lcl|pmum:103324260 26 250 + 225 Gaps:8 80.62 289 73.39 9e-119 histidine biosynthesis bifunctional protein hisIE chloroplastic
blastp_kegg lcl|gmx:100807276 26 249 + 224 Gaps:9 82.21 281 74.89 1e-118 histidine biosynthesis bifunctional protein hisIE chloroplastic-like
blastp_kegg lcl|cic:CICLE_v10005565mg 26 249 + 224 Gaps:11 82.37 278 76.42 2e-118 hypothetical protein
blastp_kegg lcl|cit:102608490 26 249 + 224 Gaps:11 82.37 278 76.42 6e-118 histidine biosynthesis bifunctional protein hisIE chloroplastic-like
blastp_kegg lcl|fve:101292080 26 250 + 225 Gaps:9 80.56 288 72.84 5e-115 histidine biosynthesis bifunctional protein hisIE chloroplastic-like
blastp_kegg lcl|pop:POPTR_0001s40210g 26 246 + 221 Gaps:8 80.07 286 72.05 4e-114 Histidine biosynthesis bifunctional protein hisIE
blastp_kegg lcl|pxb:103948885 26 250 + 225 Gaps:8 80.62 289 70.82 1e-113 histidine biosynthesis bifunctional protein hisIE chloroplastic-like
blastp_pdb 1zps_B 41 132 + 92 none 66.67 138 36.96 5e-17 mol:protein length:138 Phosphoribosyl-AMP cyclohydrolase
blastp_pdb 1zps_A 41 132 + 92 none 66.67 138 36.96 5e-17 mol:protein length:138 Phosphoribosyl-AMP cyclohydrolase
blastp_uniprot_sprot sp|O82768|HIS2_ARATH 26 246 + 221 Gaps:8 81.49 281 67.25 2e-107 Histidine biosynthesis bifunctional protein hisIE chloroplastic OS Arabidopsis thaliana GN HISN2 PE 2 SV 1
blastp_uniprot_sprot sp|Q8CXM8|HIS2_OCEIH 31 234 + 204 Gaps:27 92.56 215 35.18 5e-30 Histidine biosynthesis bifunctional protein HisIE OS Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831) GN hisI PE 3 SV 1
blastp_uniprot_sprot sp|Q7MAQ8|HIS2_WOLSU 27 246 + 220 Gaps:24 98.69 229 32.74 9e-29 Histidine biosynthesis bifunctional protein HisIE OS Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) GN hisI PE 3 SV 1
blastp_uniprot_sprot sp|Q8CQ91|HIS2_STAES 39 249 + 211 Gaps:37 95.73 211 36.63 1e-28 Histidine biosynthesis bifunctional protein HisIE OS Staphylococcus epidermidis (strain ATCC 12228) GN hisI PE 3 SV 1
blastp_uniprot_sprot sp|Q5HKP3|HIS2_STAEQ 39 234 + 196 Gaps:36 88.15 211 38.71 1e-28 Histidine biosynthesis bifunctional protein HisIE OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A) GN hisI PE 3 SV 1
blastp_uniprot_sprot sp|Q9RWD6|HIS2_DEIRA 29 244 + 216 Gaps:24 98.17 218 35.51 5e-28 Histidine biosynthesis bifunctional protein HisIE OS Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) GN hisI PE 3 SV 1
blastp_uniprot_sprot sp|Q9CLL8|HIS2_PASMU 41 237 + 197 Gaps:26 95.02 201 35.08 1e-27 Histidine biosynthesis bifunctional protein HisIE OS Pasteurella multocida (strain Pm70) GN hisI PE 3 SV 1
blastp_uniprot_sprot sp|P44434|HIS2_HAEIN 40 245 + 206 Gaps:19 93.67 221 31.88 2e-27 Histidine biosynthesis bifunctional protein HisIE OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN hisI PE 3 SV 1
blastp_uniprot_sprot sp|Q7N6I6|HIS2_PHOLL 45 234 + 190 Gaps:30 89.55 201 34.44 2e-26 Histidine biosynthesis bifunctional protein HisIE OS Photorhabdus luminescens subsp. laumondii (strain TT01) GN hisI PE 3 SV 1
blastp_uniprot_sprot sp|Q8R886|HIS2_THETN 31 237 + 207 Gaps:5 98.54 205 30.20 6e-26 Histidine biosynthesis bifunctional protein HisIE OS Thermoanaerobacter tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) GN hisI PE 3 SV 1
rpsblast_cdd gnl|CDD|177980 26 246 + 221 Gaps:9 84.13 271 71.49 1e-100 PLN02346 PLN02346 histidine biosynthesis bifunctional protein hisIE.
rpsblast_cdd gnl|CDD|179470 30 235 + 206 Gaps:30 98.52 203 33.50 5e-42 PRK02759 PRK02759 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein Reviewed.
rpsblast_cdd gnl|CDD|178825 30 134 + 105 none 84.00 125 38.10 2e-26 PRK00051 hisI phosphoribosyl-AMP cyclohydrolase Reviewed.
rpsblast_cdd gnl|CDD|30488 28 132 + 105 Gaps:1 95.50 111 40.57 1e-25 COG0139 HisI Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism].
rpsblast_cdd gnl|CDD|201829 56 130 + 75 none 100.00 75 38.67 1e-23 pfam01502 PRA-CH Phosphoribosyl-AMP cyclohydrolase. This enzyme catalyzes the third step in the histidine biosynthetic pathway. It requires Zn ions for activity.
rpsblast_cdd gnl|CDD|179005 163 246 + 84 Gaps:12 89.52 105 31.91 4e-13 PRK00400 hisE phosphoribosyl-ATP pyrophosphatase Validated.
rpsblast_cdd gnl|CDD|212141 167 231 + 65 Gaps:8 86.90 84 31.51 6e-13 cd11534 NTP-PPase_HisIE_like Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs. This family includes Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase HisIE and its homologs from all three kingdoms of life. E. coli HisIE is encoded by the hisIE gene which is formed by hisE gene fused to hisl. HisIE is a bifunctional enzyme responsible for the second and third steps of the histidine-biosynthesis pathway. Its N-terminal and C-terminal domains have phosphoribosyl-AMP cyclohydrolase (HisI) and phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) activity respectively. This family corresponds to the C-terminal domain of HisIE and includes many hisE gene encoding proteins all of which show significant sequence similarity to Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH). These proteins may be responsible for only the second step in the histidine-biosynthetic pathway irreversibly hydrolyzing phosphoribosyl-ATP (PRATP) to phosphoribosyl-AMP (PRAMP) and pyrophosphate.
rpsblast_cdd gnl|CDD|163181 163 231 + 69 Gaps:10 94.05 84 32.91 1e-10 TIGR03188 histidine_hisI phosphoribosyl-ATP pyrophosphohydrolase. This enzyme phosphoribosyl-ATP pyrophosphohydrolase catalyses the second step in the histidine biosynthesis pathway. It often occurs as a fusion protein. This model a somewhat narrower scope than Pfam model pfam01503 as some paralogs that appear to be functionally distinct are excluded from this model.

8 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
SUPERFAMILY 189 236 48 SSF101386 none none none
Pfam 56 129 74 PF01502 "KEGG:00340+3.5.4.19","UniPathway:UPA00031" Phosphoribosyl-AMP cyclohydrolase IPR002496
TIGRFAM 167 231 65 TIGR03188 "KEGG:00340+3.6.1.31","UniPathway:UPA00031" histidine_hisI: phosphoribosyl-ATP diphosphatase IPR008179
Pfam 190 233 44 PF01503 "KEGG:00340+3.6.1.31","UniPathway:UPA00031" Phosphoribosyl-ATP pyrophosphohydrolase IPR021130
SUPERFAMILY 30 134 105 SSF141734 none none none
PANTHER 21 129 109 PTHR21256 none none none
PANTHER 147 246 100 PTHR21256 none none none
ProDom 79 131 53 PD002610 "KEGG:00340+3.5.4.19","UniPathway:UPA00031" PHOSPHORIBOSYL-AMP BIOSYNTHESIS CYCLOHYDROLASE HYDROLASE HISTIDINE AMINO-ACID PRA-CH PHOSPHORIBOSYL-ATP BIFUNCTIONAL INCLUDES: IPR002496

0 Localization

0 Qtllist

0 Targeting