Protein : Qrob_P0504580.2 Q. robur
Protein Identifier  ? Qrob_P0504580.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=2) PF13324 - Grap2 and cyclin-D-interacting Gene Prediction Quality  validated
Protein length 

Sequence

Length: 245  
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0 Synonyms

1 GO Terms

Identifier Name Description
GO:0051726 regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.

12 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100243961 7 244 + 238 none 65.38 364 69.75 2e-112 cyclin-D1-binding protein 1 homolog-like
blastp_kegg lcl|pmum:103341548 7 244 + 238 none 65.38 364 69.75 6e-111 cyclin-D1-binding protein 1 homolog
blastp_kegg lcl|mdm:103402636 7 244 + 238 none 65.21 365 69.33 3e-109 cyclin-D1-binding protein 1 homolog
blastp_kegg lcl|pxb:103948201 7 244 + 238 none 65.21 365 68.91 4e-108 uncharacterized LOC103948201
blastp_kegg lcl|cit:102620219 2 244 + 243 none 66.21 367 64.61 1e-106 cyclin-D1-binding protein 1 homolog
blastp_kegg lcl|cic:CICLE_v10015542mg 2 244 + 243 none 62.31 390 64.61 4e-105 hypothetical protein
blastp_kegg lcl|pxb:103947072 7 240 + 234 none 64.11 365 66.24 4e-102 uncharacterized LOC103947072
blastp_kegg lcl|pop:POPTR_0010s12730g 6 243 + 238 Gaps:1 72.04 329 67.09 9e-102 POPTRDRAFT_726941 hypothetical protein
blastp_kegg lcl|mdm:103414231 7 240 + 234 none 63.76 367 65.81 7e-101 cyclin-D1-binding protein 1 homolog
blastp_kegg lcl|mdm:103451610 7 240 + 234 none 63.76 367 65.81 7e-101 cyclin-D1-binding protein 1 homolog
blastp_uniprot_sprot sp|Q5U4I3|CCDB1_XENLA 13 190 + 178 Gaps:27 49.85 331 27.27 2e-08 Cyclin-D1-binding protein 1 homolog OS Xenopus laevis GN ccndbp1 PE 2 SV 2
rpsblast_cdd gnl|CDD|205504 7 193 + 187 Gaps:12 66.05 271 51.96 2e-55 pfam13324 GCIP Grap2 and cyclin-D-interacting. GCIP or Grap2 and cyclin-D-interacting protein is found in eukaryotes and in the human protein CCNDBP1 residues 149-190 constitute a helix-loop-helix domain residues 190-240 an acidic region and 240-261 a leucine zipper domain. GCIP interacts with full-length Grap2 protein and with the COOH-terminal unique and SH3 domains (designated QC domain) of Grap2. It is potentially involved in the regulation of cell differentiation and proliferation through Grap2 and cyclin D-mediated signalling pathways. In mice it is involved in G1/S-phase progression of hepatocytes which in older animals is associated with the development of liver tumours. In vitro it acts as an inhibitory HLH protein for example blocking transcription of the HNF-4 promoter. In its function as a cyclin D1-binding protein it is able to reduce CDK4-mediated phosphorylation of the retinoblastoma protein and to inhibit E2F-mediated transcriptional activity. GCIP has also been shown to have interact physically with Rad (Ras associated with diabetes) Rad being important in regulating cellular senescence.

3 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Pfam 5 194 190 PF13324 none Grap2 and cyclin-D-interacting none
PANTHER 6 235 230 PTHR15492 none none IPR026907
PANTHER 6 235 230 PTHR15492:SF1 none none none

0 Localization

9 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2004_QTL1_peak_Bud_burst_A4 Qrob_Chr01 1 s_1AMVCC_444 s_1BE1VC_321 4 0 31 lod 3,2 7,4
Bourran2_2003_QTL8_peak_Bud_burst_A4 Qrob_Chr01 1 s_1AH7I_610 s_1BE1VC_321 4,6 0 28 lod 3,5 7,4
Bourran2_2007_QTL6_peak_Bud_burst_3P Qrob_Chr01 1 s_1BE1VC_321 s_1A5JRZ_890 5 0 25 lod 2,4 6
Bourran2_2014_nLBD*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 34,91 16,12 53,62 lod 2,4961 5,2
Bourran2_2014_rEpiBC*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 35,77 14,11 55,31 lod 2,9413 6,2
Bourran2_2015_nEpiBC_3P Qrob_Chr12 12 s_1B73S5_217 v_7050_211 28,31 26,37 28,45 lod 4.5 11.6
Bourran2_2015_rEpiBC_3P Qrob_Chr08 8 s_A9TNV_543 v_11837_70 9,93 9,83 11,15 lod 3.3 7.3
Bourran2_2002_QTL7_peak_Bud_burst_A4 Qrob_Chr01 1 s_1DFK66_275 s_1AMVCC_444 3,3 0 7,3 lod 9,4 14,8
Bourran2_2014_nSeqBC*_A4 Qrob_Chr01 1 s_1CFE4C_2114 s_1BDNCB_819 15,25 2 28,5 lod 2,9903 8,3

0 Targeting