Protein : Qrob_P0504570.2 Q. robur
Protein Identifier  ? Qrob_P0504570.2 Organism . Name  Quercus robur
Score  66.1 Score Type  egn
Protein Description  (M=2) PF13324 - Grap2 and cyclin-D-interacting Gene Prediction Quality  validated
Protein length 

Sequence

Length: 221  
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0 Synonyms

1 GO Terms

Identifier Name Description
GO:0051726 regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.

11 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa006856mg 1 197 + 197 none 32.57 393 78.12 9e-65 hypothetical protein
blastp_kegg lcl|rcu:RCOM_0275590 1 198 + 198 none 35.16 364 76.56 3e-63 hypothetical protein
blastp_kegg lcl|pop:POPTR_0008s12530g 1 198 + 198 none 35.36 362 75.00 2e-62 POPTRDRAFT_656870 hypothetical protein
blastp_kegg lcl|pmum:103341548 1 197 + 197 none 35.16 364 75.78 3e-62 cyclin-D1-binding protein 1 homolog
blastp_kegg lcl|vvi:100243961 1 198 + 198 Gaps:16 35.16 364 75.78 2e-59 cyclin-D1-binding protein 1 homolog-like
blastp_kegg lcl|cit:102620219 1 197 + 197 Gaps:2 35.42 367 74.62 7e-59 cyclin-D1-binding protein 1 homolog
blastp_kegg lcl|fve:101301196 1 200 + 200 Gaps:2 39.22 357 67.14 1e-58 cyclin-D1-binding protein 1 homolog
blastp_kegg lcl|cic:CICLE_v10015542mg 1 197 + 197 Gaps:2 33.33 390 74.62 2e-58 hypothetical protein
blastp_kegg lcl|csv:101213885 1 197 + 197 none 34.89 364 73.23 2e-58 cyclin-D1-binding protein 1 homolog
blastp_kegg lcl|pxb:103947072 1 197 + 197 Gaps:2 35.34 365 74.42 3e-58 uncharacterized LOC103947072
rpsblast_cdd gnl|CDD|205504 40 204 + 165 Gaps:2 35.42 271 60.42 6e-33 pfam13324 GCIP Grap2 and cyclin-D-interacting. GCIP or Grap2 and cyclin-D-interacting protein is found in eukaryotes and in the human protein CCNDBP1 residues 149-190 constitute a helix-loop-helix domain residues 190-240 an acidic region and 240-261 a leucine zipper domain. GCIP interacts with full-length Grap2 protein and with the COOH-terminal unique and SH3 domains (designated QC domain) of Grap2. It is potentially involved in the regulation of cell differentiation and proliferation through Grap2 and cyclin D-mediated signalling pathways. In mice it is involved in G1/S-phase progression of hepatocytes which in older animals is associated with the development of liver tumours. In vitro it acts as an inhibitory HLH protein for example blocking transcription of the HNF-4 promoter. In its function as a cyclin D1-binding protein it is able to reduce CDK4-mediated phosphorylation of the retinoblastoma protein and to inhibit E2F-mediated transcriptional activity. GCIP has also been shown to have interact physically with Rad (Ras associated with diabetes) Rad being important in regulating cellular senescence.

4 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 1 119 119 PTHR15492:SF1 none none none
Pfam 40 126 87 PF13324 none Grap2 and cyclin-D-interacting none
Pfam 127 204 78 PF13324 none Grap2 and cyclin-D-interacting none
PANTHER 1 119 119 PTHR15492 none none IPR026907

0 Localization

9 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2004_QTL1_peak_Bud_burst_A4 Qrob_Chr01 1 s_1AMVCC_444 s_1BE1VC_321 4 0 31 lod 3,2 7,4
Bourran2_2003_QTL8_peak_Bud_burst_A4 Qrob_Chr01 1 s_1AH7I_610 s_1BE1VC_321 4,6 0 28 lod 3,5 7,4
Bourran2_2007_QTL6_peak_Bud_burst_3P Qrob_Chr01 1 s_1BE1VC_321 s_1A5JRZ_890 5 0 25 lod 2,4 6
Bourran2_2014_nLBD*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 34,91 16,12 53,62 lod 2,4961 5,2
Bourran2_2014_rEpiBC*_A4 Qrob_Chr08 8 v_12498_318 v_12364_308 35,77 14,11 55,31 lod 2,9413 6,2
Bourran2_2015_nEpiBC_3P Qrob_Chr12 12 s_1B73S5_217 v_7050_211 28,31 26,37 28,45 lod 4.5 11.6
Bourran2_2015_rEpiBC_3P Qrob_Chr08 8 s_A9TNV_543 v_11837_70 9,93 9,83 11,15 lod 3.3 7.3
Bourran2_2002_QTL7_peak_Bud_burst_A4 Qrob_Chr01 1 s_1DFK66_275 s_1AMVCC_444 3,3 0 7,3 lod 9,4 14,8
Bourran2_2014_nSeqBC*_A4 Qrob_Chr01 1 s_1CFE4C_2114 s_1BDNCB_819 15,25 2 28,5 lod 2,9903 8,3

0 Targeting