Protein : Qrob_P0456980.2 Q. robur
Protein Identifier  ? Qrob_P0456980.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) PTHR19308:SF8 - STAR-RELATED LIPID TRANSFER PROTEIN 7, MITOCHONDRIAL (PTHR19308:SF8) Gene Prediction Quality  validated
Protein length 

Sequence

Length: 393  
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0 Synonyms

1 GO Terms

Identifier Name Description
GO:0008289 lipid binding Interacting selectively and non-covalently with a lipid.

27 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa006681mg 10 374 + 365 Gaps:23 90.00 400 67.50 1e-172 hypothetical protein
blastp_kegg lcl|pmum:103327463 10 384 + 375 Gaps:29 94.21 397 65.78 1e-168 uncharacterized LOC103327463
blastp_kegg lcl|cic:CICLE_v10028538mg 1 391 + 391 Gaps:16 96.84 412 63.66 1e-167 hypothetical protein
blastp_kegg lcl|cit:102619344 1 391 + 391 Gaps:18 99.01 403 63.41 2e-163 hypothetical protein
blastp_kegg lcl|tcc:TCM_027668 2 392 + 391 Gaps:33 100.00 408 61.76 5e-163 Polyketide cyclase/dehydrase and lipid transport superfamily protein isoform 1
blastp_kegg lcl|pop:POPTR_0014s00330g 15 391 + 377 Gaps:12 94.62 409 62.53 5e-162 hypothetical protein
blastp_kegg lcl|pxb:103935922 10 392 + 383 Gaps:21 96.46 396 66.23 2e-158 uncharacterized LOC103935922
blastp_kegg lcl|mdm:103443388 10 391 + 382 Gaps:21 95.97 397 65.88 1e-156 uncharacterized LOC103443388
blastp_kegg lcl|vvi:100254729 24 391 + 368 Gaps:54 36.33 1068 63.40 8e-156 protein STRUBBELIG-RECEPTOR FAMILY 5-like
blastp_kegg lcl|pop:POPTR_0007s15160g 25 391 + 367 Gaps:17 91.63 406 67.47 2e-155 POPTRDRAFT_764957 hypothetical protein
blastp_pdb 1ln3_B 132 286 + 155 Gaps:18 76.17 214 26.99 1e-07 mol:protein length:214 Phosphatidylcholine transfer protein
blastp_pdb 1ln3_A 132 286 + 155 Gaps:18 76.17 214 26.99 1e-07 mol:protein length:214 Phosphatidylcholine transfer protein
blastp_pdb 1ln2_B 132 286 + 155 Gaps:18 76.17 214 26.99 1e-07 mol:protein length:214 Phosphatidylcholine transfer protein
blastp_pdb 1ln2_A 132 286 + 155 Gaps:18 76.17 214 26.99 1e-07 mol:protein length:214 Phosphatidylcholine transfer protein
blastp_pdb 1ln1_A 132 286 + 155 Gaps:18 76.17 214 26.99 1e-07 mol:protein length:214 Phosphatidylcholine transfer protein
blastp_uniprot_sprot sp|Q8R1R3|STAR7_MOUSE 106 240 + 135 Gaps:9 35.92 373 30.60 3e-11 StAR-related lipid transfer protein 7 mitochondrial OS Mus musculus GN Stard7 PE 2 SV 2
blastp_uniprot_sprot sp|Q9NQZ5|STAR7_HUMAN 109 240 + 132 Gaps:9 35.41 370 30.53 3e-11 StAR-related lipid transfer protein 7 mitochondrial OS Homo sapiens GN STARD7 PE 1 SV 2
blastp_uniprot_sprot sp|Q9UKL6|PPCT_HUMAN 132 286 + 155 Gaps:18 76.17 214 26.99 4e-07 Phosphatidylcholine transfer protein OS Homo sapiens GN PCTP PE 1 SV 1
blastp_uniprot_sprot sp|P53808|PPCT_MOUSE 134 286 + 153 Gaps:12 75.23 214 26.09 8e-07 Phosphatidylcholine transfer protein OS Mus musculus GN Pctp PE 1 SV 2
blastp_uniprot_sprot sp|P53809|PPCT_RAT 134 286 + 153 Gaps:14 75.23 214 25.47 5e-06 Phosphatidylcholine transfer protein OS Rattus norvegicus GN Pctp PE 2 SV 2
rpsblast_cdd gnl|CDD|176879 89 286 + 198 Gaps:11 99.04 209 43.96 9e-66 cd08870 START_STARD2_7-like Lipid-binding START domain of mammalian STARD2 -7 and related proteins. This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD2 (also known as phosphatidylcholine transfer protein/PC-TP) and STARD7 (also known as gestational trophoblastic tumor 1/GTT1). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD2 is a cytosolic phosphatidycholine (PtdCho) transfer protein which traffics PtdCho the most common class of phospholipids in eukaryotes between membranes. It represents a minimal START domain structure. STARD2 plays roles in hepatic cholesterol metabolism in the development of atherosclerosis and may also have a mitochondrial function. The gene encoding STARD7 is overexpressed in choriocarcinoma. STARD7 appears to be involved in the intracellular trafficking of PtdCho to mitochondria. STARD7 was shown to be surface active and to interact differentially with phospholipid monolayers. It showed a preference for phosphatidylserine cholesterol and phosphatidylglycerol.
rpsblast_cdd gnl|CDD|176920 107 240 + 134 Gaps:5 64.25 207 30.83 4e-13 cd08911 START_STARD7-like Lipid-binding START domain of mammalian STARD7 and related proteins. This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD7 (also known as gestational trophoblastic tumor 1/GTT1). It belongs to the START domain family and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. The gene encoding STARD7 is overexpressed in choriocarcinoma. STARD7 appears to be involved in the intracellular trafficking of phosphatidycholine (PtdCho) to mitochondria. STARD7 was shown to be surface active and to interact differentially with phospholipid monolayers it showed a preference for phosphatidylserine cholesterol and phosphatidylglycerol.
rpsblast_cdd gnl|CDD|176851 98 234 + 137 Gaps:10 68.91 193 32.33 7e-12 cd00177 START Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins. This family includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15 and related domains such as the START domain of the Arabidopsis homeobox protein GLABRA 2. The mammalian STARDs are grouped into 8 subfamilies. This family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. For some members of this family specific lipids that bind in this pocket are known these include cholesterol (STARD1/STARD3/ STARD4/STARD5) 25-hydroxycholesterol (STARD5) phosphatidylcholine (STARD2/ STARD7/STARD10) phosphatidylethanolamine (STARD10) and ceramides (STARD11). The START domain is found either alone or in association with other domains. Mammalian STARDs participate in the control of various cellular processes including lipid trafficking between intracellular compartments lipid metabolism and modulation of signaling events. Mutation or altered expression of STARDs is linked to diseases such as cancer genetic disorders and autoimmune disease. The Arabidopsis homeobox protein GLABRA 2 suppresses root hair formation in hairless epidermal root cells.
rpsblast_cdd gnl|CDD|176880 95 256 + 162 Gaps:15 73.42 222 24.54 1e-07 cd08871 START_STARD10-like Lipid-binding START domain of mammalian STARD10 and related proteins. This subfamily includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD10 (also known as CGI-52 PTCP-like and SDCCAG28). The START domain family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD10 binds phophatidylcholine and phosphatidylethanolamine. This protein is widely expressed and is synthesized constitutively in many organs. It may function in the liver in the export of phospholipids into bile. It is concentrated in the sperm flagellum and may play a role in energy metabolism. In the mammary gland it may participate in the enrichment of lipids in milk and be a potential marker of differentiation. Its expression is induced in this gland during gestation and lactation. It is overexpressed in mammary tumors from Neu/ErbB2 transgenic mice in several breast carcinoma cell lines and in 35% of primary human breast cancers and may cooperate with c-erbB receptor signaling in breast oncogenesis. It is a potential marker of disease outcome in breast cancer loss of STARD10 expression in breast cancer strongly predicts an aggressive disease course. The lipid transfer activity of STRAD10 is downregulated by phosphorylation of its Ser284 by CK2 (casein kinase 2).
rpsblast_cdd gnl|CDD|176919 132 286 + 155 Gaps:28 78.74 207 25.77 1e-07 cd08910 START_STARD2-like Lipid-binding START domain of mammalian STARD2 and related proteins. This subgroup includes the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of STARD2 (also known as phosphatidylcholine transfer protein/PC-TP) and related proteins. It belongs to the START domain family and in turn to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. STARD2 is a cytosolic phosphatidycholine (PtdCho) transfer protein which traffics PtdCho the most common class of phospholipids in eukaryotes between membranes. It represents a minimal START domain structure. STARD2 plays roles in hepatic cholesterol metabolism in the development of atherosclerosis and may have a mitochondrial function.
rpsblast_cdd gnl|CDD|197591 99 236 + 138 Gaps:4 67.32 205 25.36 7e-07 smart00234 START in StAR and phosphatidylcholine transfer protein. putative lipid-binding domain in StAR and phosphatidylcholine transfer protein.
rpsblast_kog gnl|CDD|37972 83 286 + 204 Gaps:16 97.72 219 35.98 2e-56 KOG2761 KOG2761 KOG2761 START domain-containing proteins involved in steroidogenesis/phosphatidylcholine transfer [Lipid transport and metabolism].

11 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 345 366 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 367 392 26 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 80 379 300 PTHR19308:SF8 none none none
Phobius 43 344 302 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Gene3D 85 286 202 G3DSA:3.30.530.20 none none IPR023393
ProSiteProfiles 107 240 134 PS50848 none START domain profile. IPR002913
Coils 94 115 22 Coil none none none
Phobius 23 42 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 80 379 300 PTHR19308 none none none
SUPERFAMILY 99 287 189 SSF55961 none none none
Phobius 1 22 22 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none

0 Localization

0 Qtllist

0 Targeting