Protein : Qrob_P0355960.2 Q. robur
Protein Identifier  ? Qrob_P0355960.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=3) 3.2.1.167 - Baicalin-beta-D-glucuronidase. Code Enzyme  EC:3.2.1.31, EC:3.2.1.167
Gene Prediction Quality  validated Protein length 

Sequence

Length: 551  
Kegg Orthology  K07964
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0016798 hydrolase activity, acting on glycosyl bonds Catalysis of the hydrolysis of any glycosyl bond.
GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule.

21 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100259360 1 549 + 549 Gaps:8 99.45 548 71.19 0.0 heparanase-like protein 3-like
blastp_kegg lcl|pop:POPTR_0018s02050g 1 549 + 549 Gaps:14 96.09 563 72.64 0.0 POPTRDRAFT_261180 hypothetical protein
blastp_kegg lcl|cic:CICLE_v10010401mg 1 549 + 549 Gaps:5 99.46 551 68.80 0.0 hypothetical protein
blastp_kegg lcl|tcc:TCM_036966 1 549 + 549 Gaps:3 99.45 549 68.68 0.0 Glucuronidase 3 isoform 1
blastp_kegg lcl|vvi:100264535 20 550 + 531 Gaps:14 84.48 612 72.15 0.0 heparanase-like protein 3
blastp_kegg lcl|cit:102608348 1 549 + 549 Gaps:17 96.61 561 69.93 0.0 heparanase-like protein 3-like
blastp_kegg lcl|rcu:RCOM_0923130 36 549 + 514 Gaps:4 96.77 527 73.92 0.0 heparanase putative
blastp_kegg lcl|pmum:103319726 1 549 + 549 Gaps:19 99.07 535 69.62 0.0 heparanase-like protein 3
blastp_kegg lcl|pper:PRUPE_ppa019445mg 20 549 + 530 Gaps:23 99.22 511 72.58 0.0 hypothetical protein
blastp_kegg lcl|vvi:100255842 1 549 + 549 Gaps:11 99.11 559 64.26 0.0 heparanase-like protein 3-like
blastp_uniprot_sprot sp|Q9FZP1|HPSE3_ARATH 38 549 + 512 Gaps:7 94.22 536 59.21 0.0 Heparanase-like protein 3 OS Arabidopsis thaliana GN At5g34940 PE 2 SV 2
blastp_uniprot_sprot sp|Q8L608|HPSE2_ARATH 40 550 + 511 Gaps:14 94.81 539 47.95 5e-165 Heparanase-like protein 2 OS Arabidopsis thaliana GN At5g61250 PE 2 SV 1
blastp_uniprot_sprot sp|Q9FF10|HPSE1_ARATH 37 550 + 514 Gaps:13 94.84 543 47.38 9e-161 Heparanase-like protein 1 OS Arabidopsis thaliana GN At5g07830 PE 2 SV 1
blastp_uniprot_sprot sp|Q9LRC8|BAGLU_SCUBA 48 549 + 502 Gaps:48 91.84 527 48.55 2e-158 Baicalin-beta-D-glucuronidase OS Scutellaria baicalensis GN SGUS PE 1 SV 1
blastp_uniprot_sprot sp|Q71RP1|HPSE_RAT 147 549 + 403 Gaps:59 69.40 536 32.80 1e-28 Heparanase OS Rattus norvegicus GN Hpse PE 2 SV 1
blastp_uniprot_sprot sp|Q6YGZ1|HPSE_MOUSE 147 549 + 403 Gaps:59 69.53 535 32.26 3e-28 Heparanase OS Mus musculus GN Hpse PE 1 SV 3
blastp_uniprot_sprot sp|Q9MYY0|HPSE_BOVIN 136 549 + 414 Gaps:59 70.28 545 30.03 9e-27 Heparanase OS Bos taurus GN HPSE PE 2 SV 2
blastp_uniprot_sprot sp|Q9Y251|HPSE_HUMAN 136 443 + 308 Gaps:25 56.54 543 31.92 2e-26 Heparanase OS Homo sapiens GN HPSE PE 1 SV 2
blastp_uniprot_sprot sp|Q90YK5|HPSE_CHICK 147 549 + 403 Gaps:58 71.32 523 30.83 1e-24 Heparanase OS Gallus gallus GN HPSE PE 1 SV 1
blastp_uniprot_sprot sp|B2RY83|HPSE2_MOUSE 136 549 + 414 Gaps:67 66.39 592 27.48 4e-15 Inactive heparanase-2 OS Mus musculus GN Hpse2 PE 2 SV 1
rpsblast_cdd gnl|CDD|190706 37 354 + 318 Gaps:2 99.38 320 63.52 1e-149 pfam03662 Glyco_hydro_79n Glycosyl hydrolase family 79 N-terminal domain. Family of endo-beta-N-glucuronidase or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly insolubility and barrier properties of basement membranes and extracellular matrices. Hence cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity.

12 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 40 438 399 PTHR14363:SF11 none none none
PANTHER 469 550 82 PTHR14363:SF11 none none none
Gene3D 192 335 144 G3DSA:3.20.20.80 none none IPR013781
PANTHER 40 438 399 PTHR14363 none none IPR005199
PANTHER 469 550 82 PTHR14363 none none IPR005199
Phobius 1 26 26 SIGNAL_PEPTIDE none Signal peptide region none
Phobius 1 5 5 SIGNAL_PEPTIDE_N_REGION none N-terminal region of a signal peptide. none
Phobius 18 26 9 SIGNAL_PEPTIDE_C_REGION none C-terminal region of a signal peptide. none
SUPERFAMILY 51 398 348 SSF51445 none none IPR017853
Phobius 27 550 524 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Pfam 37 354 318 PF03662 none Glycosyl hydrolase family 79, N-terminal domain IPR005199
Phobius 6 17 12 SIGNAL_PEPTIDE_H_REGION none Hydrophobic region of a signal peptide. none

3 Localization

Analysis Start End Length
SignalP_EUK 1 25 24
SignalP_GRAM_NEGATIVE 1 24 23
SignalP_GRAM_POSITIVE 1 24 23

4 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2004_QTL5_peak_Bud_burst_A4 Qrob_Chr10 10 s_1C8OKQ_688 v_12844_707 25,6 13,9 39,9 lod 2,7 6,1
Bourran2_2002_QTL13_peak_Bud_burst_3P Qrob_Chr10 10 s_1B1AG7_637 s_1A3A1N_709 19,44 0 49,44 lod 3 5,6
Bourran2_2014_vSeqBC_A4 Qrob_Chr10 10 s_1BAM4E_1326 s_1C0HD0_1012 36,88 7,71 46,03 lod 2,6164 7,3
Champenoux_2015_nPriLBD_3P Qrob_Chr10 10 v_15000_157 v_15000_310 15,68 15,9 15,91 lod 2.4 5.5

0 Targeting