Protein : Qrob_P0351190.2 Q. robur
Protein Identifier  ? Qrob_P0351190.2 Organism . Name  Quercus robur
Score  52.0 Score Type  egn
Protein Description  (M=1) K13024 - inositol hexakisphosphate/diphosphoinositol-pentakisphosphate kinase [EC:2.7.4.21 2.7.4.24] Code Enzyme  EC:2.7.4.24, EC:2.7.4.21
Gene Prediction Quality  validated Protein length 

Sequence

Length: 350  
Kegg Orthology  K13024
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Protein Sequence Displayer

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0 Synonyms

1 GO Terms

Identifier Name Description
GO:0003993 acid phosphatase activity Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.

24 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pop:POPTR_0004s135002 1 344 + 344 none 42.63 807 90.12 0.0 POPTRDRAFT_831208 hypothetical protein
blastp_kegg lcl|pop:POPTR_0017s11280g 1 344 + 344 none 33.14 1038 89.83 0.0 POPTRDRAFT_736216 hypothetical protein
blastp_kegg lcl|vvi:100262888 1 344 + 344 Gaps:1 32.64 1051 89.50 0.0 inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1-like
blastp_kegg lcl|pvu:PHAVU_008G044100g 1 344 + 344 Gaps:1 32.57 1053 90.09 0.0 hypothetical protein
blastp_kegg lcl|sot:102595799 1 344 + 344 none 32.48 1059 88.37 0.0 inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2-like
blastp_kegg lcl|mdm:103404600 1 344 + 344 Gaps:2 47.24 724 89.47 0.0 inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2-like
blastp_kegg lcl|pmum:103329961 1 344 + 344 Gaps:2 31.84 1074 89.47 0.0 inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
blastp_kegg lcl|gmx:100776866 1 344 + 344 Gaps:1 32.57 1053 89.50 0.0 inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase-like
blastp_kegg lcl|pper:PRUPE_ppa000633mg 1 344 + 344 Gaps:2 32.26 1060 89.18 0.0 hypothetical protein
blastp_kegg lcl|tcc:TCM_018328 1 344 + 344 none 33.05 1041 88.66 0.0 Phosphoglycerate mutase-like family protein isoform 1
blastp_uniprot_sprot sp|Q9VR59|VIP1_DROME 1 308 + 308 Gaps:48 18.04 1696 50.98 4e-70 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS Drosophila melanogaster GN l(1)G0196 PE 1 SV 2
blastp_uniprot_sprot sp|Q5XHF8|VIP2_XENLA 1 280 + 280 Gaps:32 23.87 1131 54.07 1e-67 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 OS Xenopus laevis GN ppip5k2 PE 2 SV 1
blastp_uniprot_sprot sp|A7Z050|VIP1_BOVIN 1 312 + 312 Gaps:42 20.72 1477 50.65 2e-66 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS Bos taurus GN PPIP5K1 PE 2 SV 1
blastp_uniprot_sprot sp|Q6PFW1|VIP1_HUMAN 1 312 + 312 Gaps:42 21.35 1433 50.98 1e-65 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS Homo sapiens GN PPIP5K1 PE 1 SV 1
blastp_uniprot_sprot sp|P0C644|VIP1_RAT 1 280 + 280 Gaps:33 18.90 1434 53.51 4e-65 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS Rattus norvegicus GN Ppip5k1 PE 1 SV 1
blastp_uniprot_sprot sp|Q5RDF1|VIP1_PONAB 1 312 + 312 Gaps:42 21.72 1409 50.65 7e-65 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS Pongo abelii GN PPIP5K1 PE 2 SV 1
blastp_uniprot_sprot sp|Q6ZQB6|VIP2_MOUSE 1 308 + 308 Gaps:39 26.66 1129 50.83 3e-63 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 OS Mus musculus GN Ppip5k2 PE 1 SV 3
blastp_uniprot_sprot sp|P91309|VIP1_CAEEL 1 305 + 305 Gaps:46 25.02 1323 45.92 5e-63 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS Caenorhabditis elegans GN F46F11.1 PE 3 SV 3
blastp_uniprot_sprot sp|A2ARP1|VIP1_MOUSE 1 280 + 280 Gaps:33 18.87 1436 53.51 3e-62 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS Mus musculus GN Ppip5k1 PE 2 SV 1
blastp_uniprot_sprot sp|O43314|VIP2_HUMAN 1 308 + 308 Gaps:39 24.22 1243 50.83 1e-60 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 OS Homo sapiens GN PPIP5K2 PE 1 SV 3
rpsblast_cdd gnl|CDD|201158 187 309 + 123 Gaps:17 32.42 327 35.85 6e-17 pfam00328 His_Phos_2 Histidine phosphatase superfamily (branch 2). The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and more surprisingly differ in the position in sequence and in three dimensions of a catalytically essential acidic residue. The superfamily may be divided into two main branches.The smaller branch 2 contains predominantly eukaryotic proteins. The catalytic functions in members include phytase glucose-1-phosphatase and multiple inositol polyphosphate phosphatase. The in vivo roles of the mammalian acid phosphatases in branch 2 are not fully understood although activity against lysophosphatidic acid and tyrosine-phosphorylated proteins has been demonstrated.
rpsblast_cdd gnl|CDD|132717 204 296 + 93 Gaps:5 36.36 242 42.05 2e-16 cd07061 HP_HAP_like Histidine phosphatase domain found in histidine acid phosphatases and phytases contains a His residue which is phosphorylated during the reaction. Catalytic domain of HAP (histidine acid phosphatases) and phytases (myo-inositol hexakisphosphate phosphohydrolases). The conserved catalytic core of this domain contains a His residue which is phosphorylated in the reaction. Functions in this subgroup include roles in metabolism signaling or regulation for example Escherichia coli glucose-1-phosphatase functions to scavenge glucose from glucose-1-phosphate and the signaling molecules inositol 1 3 4 5 6-pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) are in vivo substrates for eukaryotic multiple inositol polyphosphate phosphatase 1 (Minpp1). Phytases scavenge phosphate from extracellular sources and are added to animal feed while prostatic acid phosphatase (PAP) has been used for many years as a serum marker for prostate cancer. Recently PAP has been shown in mouse models to suppress pain by functioning as an ecto-5prime-nucleotidase. In vivo it dephosphorylates extracellular adenosine monophosphate (AMP) generating adenosine and leading to the activation of A1-adenosine receptors in dorsal spinal cord.
rpsblast_cdd gnl|CDD|132716 206 267 + 62 Gaps:15 30.72 153 40.43 1e-07 cd07040 HP Histidine phosphatase domain found in a functionally diverse set of proteins mostly phosphatases contains a His residue which is phosphorylated during the reaction. Catalytic domain of a functionally diverse set of proteins most of which are phosphatases. The conserved catalytic core of this domain contains a His residue which is phosphorylated in the reaction. This set of proteins includes cofactor-dependent and cofactor-independent phosphoglycerate mutases (dPGM and BPGM respectively) fructose-2 6-bisphosphatase (F26BP)ase Sts-1 SixA histidine acid phosphatases phytases and related proteins. Functions include roles in metabolism signaling or regulation for example F26BPase affects glycolysis and gluconeogenesis through controlling the concentration of F26BP BPGM controls the concentration of 2 3-BPG (the main allosteric effector of hemoglobin in human blood cells) human Sts-1 is a T-cell regulator Escherichia coli Six A participates in the ArcB-dependent His-to-Asp phosphorelay signaling system phytases scavenge phosphate from extracellular sources. Deficiency and mutation in many of the human members result in disease for example erythrocyte BPGM deficiency is a disease associated with a decrease in the concentration of 2 3-BPG. Clinical applications include the use of prostatic acid phosphatase (PAP) as a serum marker for prostate cancer. Agricultural applications include the addition of phytases to animal feed.
rpsblast_kog gnl|CDD|36275 5 344 + 340 Gaps:26 30.84 1018 58.60 1e-119 KOG1057 KOG1057 KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1 involved in regulation of actin cytoskeleton [Cytoskeleton].

7 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 4 344 341 PTHR12750 none none none
SUPERFAMILY 188 290 103 SSF53254 none none IPR029033
SUPERFAMILY 25 102 78 SSF53254 none none IPR029033
Pfam 66 325 260 PF00328 none Histidine phosphatase superfamily (branch 2) IPR000560
ProSitePatterns 67 81 15 PS00616 none Histidine acid phosphatases phosphohistidine signature. IPR000560
Gene3D 66 96 31 G3DSA:3.40.50.1240 none none IPR029033
Gene3D 199 284 86 G3DSA:3.40.50.1240 none none IPR029033

0 Localization

1 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2003_QTL2_peak_Bud_burst_A4 Qrob_Chr02 2 s_1B0H8U_259 s_1CB1VL_554 17 0 87 lod 3,3 8,7

0 Targeting