Protein : Qrob_P0324910.2 Q. robur
Protein Identifier  ? Qrob_P0324910.2 Organism . Name  Quercus robur
Score  99.1 Score Type  egn
Protein Description  (M=12) KOG1052//KOG1053//KOG1054//KOG4440 - Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits [Inorganic ion transport and metabolism Amino acid transport and metabolism Signal transduction mechanisms]. // Glutamate-gated NMDA-type ion channel receptor subunit GRIN2A and related subunits [Inorganic ion transport and metabolism Amino acid transport and metabolism Signal transduction mechanisms]. // Glutamate-gated AMPA-type ion channel receptor subunit GluR2 and related subunits [Inorganic ion transport and metabolism Amino acid transport and metabolism Signal transduction mechanisms]. // NMDA selective glutamate-gated ion channel receptor subunit GRIN1 [Inorganic ion transport and metabolism Amino acid transport and metabolism Signal transduction mechanisms]. Gene Prediction Quality  validated
Protein length 

Sequence

Length: 918  
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0004970 ionotropic glutamate receptor activity Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.

39 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pvu:PHAVU_006G179300g 11 897 + 887 Gaps:34 95.22 942 55.18 0.0 hypothetical protein
blastp_kegg lcl|gmx:100818619 3 916 + 914 Gaps:62 98.40 939 53.79 0.0 glutamate receptor 2.7-like
blastp_kegg lcl|cam:101492454 6 907 + 902 Gaps:45 98.67 905 54.87 0.0 glutamate receptor 2.7-like
blastp_kegg lcl|mtr:MTR_2g015270 5 905 + 901 Gaps:91 98.43 1083 53.38 0.0 Glutamate receptor 2.7
blastp_kegg lcl|pmum:103324853 2 915 + 914 Gaps:41 98.80 916 53.48 0.0 glutamate receptor 2.7-like
blastp_kegg lcl|tcc:TCM_029764 6 916 + 911 Gaps:48 82.36 1111 55.30 0.0 Glutamate-gated kainate-type ion channel receptor subunit GluR5 putative
blastp_kegg lcl|pvu:PHAVU_003G057300g 22 856 + 835 Gaps:35 93.18 895 55.52 0.0 hypothetical protein
blastp_kegg lcl|gmx:100780320 4 856 + 853 Gaps:33 94.77 899 53.52 0.0 glutamate receptor 2.7-like
blastp_kegg lcl|rcu:RCOM_1012900 55 828 + 774 Gaps:25 91.70 843 56.79 0.0 glutamate receptor 2 plant putative
blastp_kegg lcl|tcc:TCM_029763 1 862 + 862 Gaps:41 93.91 919 54.35 0.0 Glutamate-gated kainate-type ion channel receptor subunit GluR5 putative
blastp_pdb 3kg2_D 455 837 + 383 Gaps:59 50.55 823 24.52 4e-17 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3kg2_C 455 837 + 383 Gaps:59 50.55 823 24.52 4e-17 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3kg2_B 455 837 + 383 Gaps:59 50.55 823 24.52 4e-17 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3kg2_A 455 837 + 383 Gaps:59 50.55 823 24.52 4e-17 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3t0n_A 29 352 + 324 Gaps:33 83.97 368 24.27 6e-09 mol:protein length:368 Twin-arginine translocation pathway signal
blastp_uniprot_sprot sp|O81078|GLR29_ARATH 20 866 + 847 Gaps:85 90.21 940 33.84 3e-122 Glutamate receptor 2.9 OS Arabidopsis thaliana GN GLR2.9 PE 2 SV 1
blastp_uniprot_sprot sp|Q8LGN0|GLR27_ARATH 30 823 + 794 Gaps:76 84.66 952 33.25 4e-121 Glutamate receptor 2.7 OS Arabidopsis thaliana GN GLR2.7 PE 2 SV 3
blastp_uniprot_sprot sp|Q9LFN8|GLR26_ARATH 10 851 + 842 Gaps:101 89.45 967 32.14 7e-121 Glutamate receptor 2.6 OS Arabidopsis thaliana GN GLR2.6 PE 2 SV 2
blastp_uniprot_sprot sp|Q9LFN5|GLR25_ARATH 36 857 + 822 Gaps:84 91.50 918 32.38 3e-119 Glutamate receptor 2.5 OS Arabidopsis thaliana GN GLR2.5 PE 2 SV 2
blastp_uniprot_sprot sp|Q9C5V5|GLR28_ARATH 15 866 + 852 Gaps:86 90.39 947 33.41 7e-119 Glutamate receptor 2.8 OS Arabidopsis thaliana GN GLR2.8 PE 2 SV 2
blastp_uniprot_sprot sp|O81776|GLR24_ARATH 16 796 + 781 Gaps:82 87.83 896 33.80 9e-116 Glutamate receptor 2.4 OS Arabidopsis thaliana GN GLR2.4 PE 2 SV 2
blastp_uniprot_sprot sp|Q8GXJ4|GLR34_ARATH 37 821 + 785 Gaps:98 84.57 959 31.81 4e-113 Glutamate receptor 3.4 OS Arabidopsis thaliana GN GLR3.4 PE 2 SV 2
blastp_uniprot_sprot sp|Q84W41|GLR36_ARATH 34 844 + 811 Gaps:90 91.81 903 30.64 8e-113 Glutamate receptor 3.6 OS Arabidopsis thaliana GN GLR3.6 PE 2 SV 1
blastp_uniprot_sprot sp|O04660|GLR21_ARATH 11 822 + 812 Gaps:84 92.12 901 31.33 2e-111 Glutamate receptor 2.1 OS Arabidopsis thaliana GN GLR2.1 PE 2 SV 2
blastp_uniprot_sprot sp|Q93YT1|GLR32_ARATH 10 823 + 814 Gaps:108 92.54 912 31.04 2e-111 Glutamate receptor 3.2 OS Arabidopsis thaliana GN GLR3.2 PE 1 SV 2
rpsblast_cdd gnl|CDD|107361 36 404 + 369 Gaps:48 99.14 350 31.99 6e-63 cd06366 PBP1_GABAb_receptor Ligand-binding domain of GABAb receptors which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). Ligand-binding domain of GABAb receptors which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and like glutamate and other transmitters acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha_i proteins and activation causes a decrease in calcium an increase in potassium membrane conductance and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release for example.
rpsblast_cdd gnl|CDD|189368 560 812 + 253 Gaps:38 98.13 268 30.42 4e-39 pfam00060 Lig_chan Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.
rpsblast_cdd gnl|CDD|201592 54 379 + 326 Gaps:32 96.79 343 25.60 1e-28 pfam01094 ANF_receptor Receptor family ligand binding region. This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.
rpsblast_cdd gnl|CDD|153138 90 332 + 243 Gaps:33 61.49 348 27.10 2e-28 cd06350 PBP1_GPCR_family_C_like Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The metabotropic glutamate receptors (mGluR) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. The mGluRs are coupled to G proteins and are thus distinct from the iGluRs which internally contain ligand-gated ion channels. The mGluR structure is divided into three regions: the extracellular region the seven-spanning transmembrane region and the cytoplasmic region. The extracellular region is further devided into the ligand-binding domain (LBD) and the cysteine-rich domain. The LBD has sequence similarity to the LIVBP which is a bacterial periplasmic protein (PBP) as well as to the extracellular region of both iGluR and the gamma-aminobutyric acid (GABA)b receptor. iGluRs are divided into three main subtypes based on pharmacological profile: NMDA AMPA and kainate receptors. All family C GPCRs have a large extracellular N terminus that contain a domain with homology to bacterial periplasmic amino acid-binding proteins.
rpsblast_cdd gnl|CDD|153137 36 286 + 251 Gaps:28 84.23 298 23.51 1e-26 cd06269 PBP1_glutamate_receptors_like Family C G-protein couples receptors (GPCRs) membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs) and the N-terminal leucine/isoleucine/valine- binding protein (LIVBP)-like domain of the ionotropic glutamate receptors. This CD represents the ligand-binding domain of the family C G-protein couples receptors (GPCRs) membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs) and the N-terminal leucine/isoleucine/valine- binding protein (LIVBP)-like domain of the ionotropic glutamate receptors all of which are structurally similar and related to the periplasmic-binding fold type I family. The family C GPCRs consist of metabotropic glutamate receptor (mGluR) receptors a calcium-sensing receptor (CaSR) gamma-aminobutyric receptors (GABAb) the promiscuous L-alpha-amino acid receptor GPR6A families of taste and pheromone receptors and orphan receptors. Truncated splicing variants of the orphan receptors are not included in this CD. The family C GPCRs are activated by endogenous agonists such as amino acids ions and sugar based molecules. Their amino terminal ligand-binding region is homologous to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). The ionotropic glutamate receptors (iGluRs) have an integral ion channel and are subdivided into three major groups based on their pharmacology and structural similarities: NMDA receptors AMPA receptors and kainate receptors. The family of membrane bound guanylyl cyclases is further divided into three subfamilies: the ANP receptor (GC-A)/C-type natriuretic peptide receptor (GC-B) the heat-stable enterotoxin receptor (GC-C)/sensory organ specific membrane GCs such as retinal receptors (GC-E GC-F) and olfactory receptors (GC-D and GC-G).

32 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 30 558 529 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Gene3D 150 310 161 G3DSA:3.40.50.2300 none none none
Gene3D 549 680 132 G3DSA:1.10.287.70 none none none
Phobius 11 24 14 SIGNAL_PEPTIDE_H_REGION none Hydrophobic region of a signal peptide. none
PANTHER 421 841 421 PTHR18966 none none none
SUPERFAMILY 36 398 363 SSF53822 none none IPR028082
SUPERFAMILY 428 435 8 SSF53822 none none IPR028082
PIRSF 6 913 908 PIRSF037090 none none IPR017103
SUPERFAMILY 424 563 140 SSF53850 none none none
SUPERFAMILY 664 784 121 SSF53850 none none none
Phobius 580 590 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 610 620 11 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 621 645 25 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Gene3D 47 149 103 G3DSA:3.40.50.2300 none none none
Gene3D 311 372 62 G3DSA:3.40.50.2300 none none none
Pfam 464 784 321 PF00497 none Bacterial extracellular solute-binding proteins, family 3 none
Pfam 54 375 322 PF01094 none Receptor family ligand binding region IPR001828
Phobius 559 579 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
SMART 442 785 344 SM00079 none Eukaryotic homologues of bacterial periplasmic substrate binding proteins. IPR001320
PANTHER 421 841 421 PTHR18966:SF6 none none none
PANTHER 74 403 330 PTHR18966:SF6 none none none
Phobius 808 831 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 832 917 86 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Pfam 558 814 257 PF00060 none Ligand-gated ion channel IPR001320
PANTHER 74 403 330 PTHR18966 none none none
Phobius 1 10 10 SIGNAL_PEPTIDE_N_REGION none N-terminal region of a signal peptide. none
Phobius 646 807 162 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 25 29 5 SIGNAL_PEPTIDE_C_REGION none C-terminal region of a signal peptide. none
Phobius 591 609 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Gene3D 438 536 99 G3DSA:3.40.190.10 none none none

5 Localization

Analysis Start End Length
TMHMM 809 831 22
SignalP_EUK 1 29 28
TMHMM 557 579 22
TMHMM 5 27 22
TMHMM 621 643 22

0 Qtllist

0 Targeting