Protein : Qrob_P0286140.2 Q. robur
Protein Identifier  ? Qrob_P0286140.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) PTHR12599 - PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE Gene Prediction Quality  validated
Protein length 

Sequence

Length: 210  
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0006729 tetrahydrobiopterin biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine.
GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O.

21 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pop:POPTR_0012s11410g 1 194 + 194 Gaps:3 92.06 214 64.47 1e-85 hypothetical protein
blastp_kegg lcl|cic:CICLE_v10032722mg 1 194 + 194 Gaps:7 92.13 216 66.33 8e-85 hypothetical protein
blastp_kegg lcl|pxb:103953705 3 194 + 192 Gaps:3 91.39 209 62.83 1e-82 uncharacterized LOC103953705
blastp_kegg lcl|tcc:TCM_014799 17 194 + 178 Gaps:2 83.02 212 69.89 1e-82 Pterin-4-alpha-carbinolamine dehydratase 1 isoform 1
blastp_kegg lcl|mdm:103439565 3 194 + 192 Gaps:3 91.39 209 63.35 4e-80 uncharacterized LOC103439565
blastp_kegg lcl|cit:102612285 11 194 + 184 Gaps:5 65.61 285 67.38 4e-79 uncharacterized LOC102612285
blastp_kegg lcl|fve:101312487 4 199 + 196 Gaps:6 94.29 210 62.12 9e-78 putative pterin-4-alpha-carbinolamine dehydratase-like
blastp_kegg lcl|rcu:RCOM_1502880 4 194 + 191 Gaps:2 91.83 208 63.35 9e-78 pterin-4-alpha-carbinolamine dehydratase putative
blastp_kegg lcl|pper:PRUPE_ppa011514mg 4 194 + 191 Gaps:3 91.79 207 66.32 6e-77 hypothetical protein
blastp_kegg lcl|pop:POPTR_0015s12200g 8 194 + 187 Gaps:5 87.74 212 63.44 7e-77 POPTRDRAFT_575504 hypothetical protein
blastp_uniprot_sprot sp|Q8KFI4|PHS_CHLTE 91 199 + 109 Gaps:1 97.30 111 27.78 1e-09 Putative pterin-4-alpha-carbinolamine dehydratase OS Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS) GN CT0342 PE 3 SV 1
blastp_uniprot_sprot sp|B0JQV0|PHS_MICAN 90 182 + 93 Gaps:1 79.31 116 32.61 2e-09 Putative pterin-4-alpha-carbinolamine dehydratase OS Microcystis aeruginosa (strain NIES-843) GN MAE_39970 PE 3 SV 1
blastp_uniprot_sprot sp|Q7NM43|PHS1_GLOVI 89 182 + 94 Gaps:1 80.17 116 30.11 1e-08 Putative pterin-4-alpha-carbinolamine dehydratase 1 OS Gloeobacter violaceus (strain PCC 7421) GN gll0926 PE 3 SV 1
blastp_uniprot_sprot sp|B3QQ83|PHS_CHLP8 91 199 + 109 Gaps:1 97.30 111 25.00 9e-08 Putative pterin-4-alpha-carbinolamine dehydratase OS Chlorobaculum parvum (strain NCIB 8327) GN Cpar_1693 PE 3 SV 1
blastp_uniprot_sprot sp|Q7NK35|PHS2_GLOVI 104 173 + 70 Gaps:1 75.00 92 28.99 4e-07 Putative pterin-4-alpha-carbinolamine dehydratase 2 OS Gloeobacter violaceus (strain PCC 7421) GN gsl1645 PE 3 SV 1
blastp_uniprot_sprot sp|B3ECB9|PHS_CHLL2 90 182 + 93 Gaps:1 81.42 113 27.17 7e-07 Putative pterin-4-alpha-carbinolamine dehydratase OS Chlorobium limicola (strain DSM 245 / NBRC 103803) GN Clim_1125 PE 3 SV 1
blastp_uniprot_sprot sp|Q60BH8|PHS_METCA 86 164 + 79 Gaps:2 67.54 114 31.17 2e-06 Putative pterin-4-alpha-carbinolamine dehydratase OS Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) GN MCA0497 PE 3 SV 1
blastp_uniprot_sprot sp|A1TZA3|PHS_MARAV 90 182 + 93 Gaps:1 82.88 111 30.43 3e-06 Putative pterin-4-alpha-carbinolamine dehydratase OS Marinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) GN Maqu_0976 PE 3 SV 1
rpsblast_cdd gnl|CDD|189944 105 182 + 78 Gaps:4 77.08 96 32.43 4e-14 pfam01329 Pterin_4a Pterin 4 alpha carbinolamine dehydratase. Pterin 4 alpha carbinolamine dehydratase is also known as DCoH (dimerisation cofactor of hepatocyte nuclear factor 1-alpha).
rpsblast_cdd gnl|CDD|48349 120 193 + 74 Gaps:6 92.11 76 38.57 1e-10 cd00913 PCD_DCoH_subfamily_a PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD) also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1) is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating with specific DNA binding proteins such as HNF-1alpha (hepatocyte nuclear factor-1) and Xenopus enhancer of rudimentary homologue (XERH). DCoH also catalyzes the dehydration of 4alpha- hydroxy- tetrahydrobiopterin (4alpha-OH-BH4) to quinoiddihydrobiopterin a percursor of the phenylalanine hydroxylase cofactor BH4 (tetrahydrobiopterin). The DCoH homodimer has a saddle-shaped structure similar to that of TBP (TATA binding protein)..
rpsblast_cdd gnl|CDD|48348 120 182 + 63 Gaps:4 78.67 75 33.90 2e-07 cd00488 PCD_DCoH PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD) also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1) is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating with specific DNA binding proteins such as HNF-1alpha (hepatocyte nuclear factor-1) and Xenopus enhancer of rudimentary homologue (XERH). DCoH also catalyzes the dehydration of 4alpha- hydroxy- tetrahydrobiopterin (4alpha-OH-BH4) to quinoiddihydrobiopterin a percursor of the phenylalanine hydroxylase cofactor BH4 (tetrahydrobiopterin). The DCoH homodimer has a saddle-shaped structure similar to that of TBP (TATA binding protein). Two DCoH proteins have been identifed in humans: DCoH1 and DCoH2. Mutations in human DCoH1 cause hyperphenylalaninemia. Loss of enzymic activity of DCoH in humans is associated with the depigmentation disorder vitiligo. DCoH1 has been reported to be overexpessed in colon cancer carcinomas and in malignant melanomas..

5 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 104 183 80 G3DSA:3.30.1360.20 "MetaCyc:PWY-7158" none IPR001533
Pfam 104 183 80 PF01329 "MetaCyc:PWY-7158" Pterin 4 alpha carbinolamine dehydratase IPR001533
PANTHER 48 182 135 PTHR12599:SF3 none none none
SUPERFAMILY 104 195 92 SSF55248 "MetaCyc:PWY-7158" none IPR001533
PANTHER 48 182 135 PTHR12599 "MetaCyc:PWY-7158";signature_desc=PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE none IPR001533

0 Localization

8 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran_2000_2002_QTL7_Delta.F Qrob_Chr09 9 v_5944_442 s_1BA1PC_866 23.51 10,96 35,74 lod 4.1466 0.041
Bourran2_2003_QTL11_peak_Bud_burst_3P Qrob_Chr09 9 s_1CGP2H_273 v_15801_330 27,16 4,16 48,16 lod 2,3 5,1
Bourran2_2004_QTL12_peak_Bud_burst_3P Qrob_Chr09 9 s_1BDO6G_250 s_1A83AM_496 34,31 9,31 44,31 lod 3,6 7,6
Bourran2_2004_QTL14_peak_Bud_burst_A4 Qrob_Chr09 9 s_1BY6BQ_440 s_1AOIKO_756 16,83 10,33 22,33 lod 3,8 9
Bourran2_2015_nEpis_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 34,94 34,88 37,45 lod 3.1 7
Bourran2_2015_nSecLBD_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 35,81 34,88 37,45 lod 4.4 10.4
PM_1999_QTL15_peak_Bud_burst_3P Qrob_Chr09 9 s_1CGP2H_273 v_15801_330 27,16 9,16 47,16 lod 3,6 6,5
Bourran1_2003_QTL5_peak_Bud_burst_3P Qrob_Chr09 9 s_1ATM17_504 s_1AYZFM_899 29,81 19,81 41,81 lod 3,3 8,9

1 Targeting

Analysis Start End Length Location Reliability Signal Peptide Cut Off Mitochondrion Cut Off Network Signal Peptide Length
TargetP 1 42   Mitochondrion 5 0.157 0.360 NON-PLANT 42