Protein : Qrob_P0273120.2 Q. robur
Protein Identifier  ? Qrob_P0273120.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=25) K05387 - glutamate receptor, ionotropic, other eukaryote Gene Prediction Quality  validated
Protein length 

Sequence

Length: 751  
Kegg Orthology  K05387
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0004970 ionotropic glutamate receptor activity Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.

33 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|tcc:TCM_033827 1 686 + 686 Gaps:32 80.86 888 55.85 0.0 Glutamate-gated kainate-type ion channel receptor subunit GluR5 putative
blastp_kegg lcl|pmum:103320439 4 708 + 705 Gaps:31 81.33 905 55.43 0.0 glutamate receptor 2.9-like
blastp_kegg lcl|pop:POPTR_0014s02840g 6 714 + 709 Gaps:37 90.86 810 55.30 0.0 hypothetical protein
blastp_kegg lcl|pper:PRUPE_ppa020816mg 9 729 + 721 Gaps:54 91.47 797 53.22 0.0 hypothetical protein
blastp_kegg lcl|pop:POPTR_0014s02880g 1 738 + 738 Gaps:53 91.89 826 51.78 0.0 hypothetical protein
blastp_kegg lcl|fve:101314629 7 720 + 714 Gaps:33 89.22 835 49.40 0.0 glutamate receptor 2.7-like
blastp_kegg lcl|pmum:103320440 1 693 + 693 Gaps:59 84.97 845 51.95 0.0 glutamate receptor 2.7-like
blastp_kegg lcl|pxb:103955089 8 695 + 688 Gaps:102 87.87 1022 54.23 0.0 glutamate receptor 2.5-like
blastp_kegg lcl|cam:101491935 2 728 + 727 Gaps:54 83.37 920 48.89 0.0 glutamate receptor 2.9-like
blastp_kegg lcl|pvu:PHAVU_001G022400g 1 732 + 732 Gaps:51 83.22 912 46.64 0.0 hypothetical protein
blastp_pdb 3kg2_D 337 526 + 190 Gaps:35 26.61 823 22.83 8e-06 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3kg2_C 337 526 + 190 Gaps:35 26.61 823 22.83 8e-06 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3kg2_B 337 526 + 190 Gaps:35 26.61 823 22.83 8e-06 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3kg2_A 337 526 + 190 Gaps:35 26.61 823 22.83 8e-06 mol:protein length:823 Glutamate receptor 2
blastp_uniprot_sprot sp|Q9LFN5|GLR25_ARATH 8 691 + 684 Gaps:84 79.96 918 31.74 4e-104 Glutamate receptor 2.5 OS Arabidopsis thaliana GN GLR2.5 PE 2 SV 2
blastp_uniprot_sprot sp|Q9LFN8|GLR26_ARATH 8 689 + 682 Gaps:99 76.01 967 30.48 2e-100 Glutamate receptor 2.6 OS Arabidopsis thaliana GN GLR2.6 PE 2 SV 2
blastp_uniprot_sprot sp|Q8LGN0|GLR27_ARATH 12 714 + 703 Gaps:93 77.73 952 32.57 1e-96 Glutamate receptor 2.7 OS Arabidopsis thaliana GN GLR2.7 PE 2 SV 3
blastp_uniprot_sprot sp|Q93YT1|GLR32_ARATH 7 687 + 681 Gaps:98 80.81 912 30.94 1e-96 Glutamate receptor 3.2 OS Arabidopsis thaliana GN GLR3.2 PE 1 SV 2
blastp_uniprot_sprot sp|Q7XJL2|GLR31_ARATH 8 687 + 680 Gaps:101 79.80 921 31.16 3e-95 Glutamate receptor 3.1 OS Arabidopsis thaliana GN GLR3.1 PE 2 SV 2
blastp_uniprot_sprot sp|O04660|GLR21_ARATH 7 678 + 672 Gaps:85 80.02 901 30.93 1e-93 Glutamate receptor 2.1 OS Arabidopsis thaliana GN GLR2.1 PE 2 SV 2
blastp_uniprot_sprot sp|Q84W41|GLR36_ARATH 4 686 + 683 Gaps:104 80.73 903 31.14 1e-91 Glutamate receptor 3.6 OS Arabidopsis thaliana GN GLR3.6 PE 2 SV 1
blastp_uniprot_sprot sp|Q9SDQ4|GLR37_ARATH 7 687 + 681 Gaps:113 79.26 921 31.64 1e-90 Glutamate receptor 3.7 OS Arabidopsis thaliana GN GLR3.7 PE 2 SV 2
blastp_uniprot_sprot sp|O81776|GLR24_ARATH 7 659 + 653 Gaps:82 76.45 896 30.95 4e-88 Glutamate receptor 2.4 OS Arabidopsis thaliana GN GLR2.4 PE 2 SV 2
blastp_uniprot_sprot sp|O81078|GLR29_ARATH 1 679 + 679 Gaps:90 76.28 940 31.24 2e-87 Glutamate receptor 2.9 OS Arabidopsis thaliana GN GLR2.9 PE 2 SV 1
rpsblast_cdd gnl|CDD|107361 7 263 + 257 Gaps:75 73.71 350 32.17 9e-34 cd06366 PBP1_GABAb_receptor Ligand-binding domain of GABAb receptors which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). Ligand-binding domain of GABAb receptors which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and like glutamate and other transmitters acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha_i proteins and activation causes a decrease in calcium an increase in potassium membrane conductance and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release for example.
rpsblast_cdd gnl|CDD|189368 430 668 + 239 Gaps:33 97.76 268 29.39 7e-32 pfam00060 Lig_chan Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.
rpsblast_cdd gnl|CDD|197504 526 637 + 112 Gaps:8 88.72 133 26.27 2e-13 smart00079 PBPe Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb.
rpsblast_cdd gnl|CDD|153138 7 262 + 256 Gaps:83 65.80 348 24.02 9e-10 cd06350 PBP1_GPCR_family_C_like Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The metabotropic glutamate receptors (mGluR) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. The mGluRs are coupled to G proteins and are thus distinct from the iGluRs which internally contain ligand-gated ion channels. The mGluR structure is divided into three regions: the extracellular region the seven-spanning transmembrane region and the cytoplasmic region. The extracellular region is further devided into the ligand-binding domain (LBD) and the cysteine-rich domain. The LBD has sequence similarity to the LIVBP which is a bacterial periplasmic protein (PBP) as well as to the extracellular region of both iGluR and the gamma-aminobutyric acid (GABA)b receptor. iGluRs are divided into three main subtypes based on pharmacological profile: NMDA AMPA and kainate receptors. All family C GPCRs have a large extracellular N terminus that contain a domain with homology to bacterial periplasmic amino acid-binding proteins.
rpsblast_cdd gnl|CDD|153137 7 128 + 122 Gaps:24 45.64 298 22.06 2e-08 cd06269 PBP1_glutamate_receptors_like Family C G-protein couples receptors (GPCRs) membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs) and the N-terminal leucine/isoleucine/valine- binding protein (LIVBP)-like domain of the ionotropic glutamate receptors. This CD represents the ligand-binding domain of the family C G-protein couples receptors (GPCRs) membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs) and the N-terminal leucine/isoleucine/valine- binding protein (LIVBP)-like domain of the ionotropic glutamate receptors all of which are structurally similar and related to the periplasmic-binding fold type I family. The family C GPCRs consist of metabotropic glutamate receptor (mGluR) receptors a calcium-sensing receptor (CaSR) gamma-aminobutyric receptors (GABAb) the promiscuous L-alpha-amino acid receptor GPR6A families of taste and pheromone receptors and orphan receptors. Truncated splicing variants of the orphan receptors are not included in this CD. The family C GPCRs are activated by endogenous agonists such as amino acids ions and sugar based molecules. Their amino terminal ligand-binding region is homologous to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). The ionotropic glutamate receptors (iGluRs) have an integral ion channel and are subdivided into three major groups based on their pharmacology and structural similarities: NMDA receptors AMPA receptors and kainate receptors. The family of membrane bound guanylyl cyclases is further divided into three subfamilies: the ANP receptor (GC-A)/C-type natriuretic peptide receptor (GC-B) the heat-stable enterotoxin receptor (GC-C)/sensory organ specific membrane GCs such as retinal receptors (GC-E GC-F) and olfactory receptors (GC-D and GC-G).
rpsblast_kog gnl|CDD|36270 120 689 + 570 Gaps:83 88.57 656 28.06 2e-59 KOG1052 KOG1052 KOG1052 Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits [Inorganic ion transport and metabolism Amino acid transport and metabolism Signal transduction mechanisms].

28 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Pfam 428 668 241 PF00060 none Ligand-gated ion channel IPR001320
SUPERFAMILY 284 432 149 SSF53850 none none none
SUPERFAMILY 530 637 108 SSF53850 none none none
Pfam 335 638 304 PF00497 none Bacterial extracellular solute-binding proteins, family 3 none
Phobius 430 448 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 662 685 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Gene3D 5 73 69 G3DSA:3.40.50.2300 none none none
Gene3D 193 229 37 G3DSA:3.40.50.2300 none none none
Gene3D 417 553 137 G3DSA:1.10.287.70 none none none
Phobius 454 473 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 288 689 402 PTHR18966:SF6 none none none
PANTHER 12 262 251 PTHR18966 none none none
PANTHER 288 689 402 PTHR18966 none none none
Pfam 6 115 110 PF01094 none Receptor family ligand binding region IPR001828
SMART 309 642 334 SM00079 none Eukaryotic homologues of bacterial periplasmic substrate binding proteins. IPR001320
Phobius 686 691 6 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 714 750 37 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 1 429 429 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 506 661 156 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 474 484 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 692 713 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
SUPERFAMILY 288 300 13 SSF53822 none none IPR028082
SUPERFAMILY 7 257 251 SSF53822 none none IPR028082
Phobius 485 505 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Gene3D 305 401 97 G3DSA:3.40.190.10 none none none
Gene3D 599 637 39 G3DSA:3.40.190.10 none none none
Phobius 449 453 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 12 262 251 PTHR18966:SF6 none none none

5 Localization

Analysis Start End Length
TMHMM 458 472 14
TMHMM 431 448 17
TMHMM 691 713 22
TMHMM 485 507 22
TMHMM 662 684 22

11 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2003_QTL2_peak_Bud_burst_A4 Qrob_Chr02 2 s_1B0H8U_259 s_1CB1VL_554 17 0 87 lod 3,3 8,7
Bourran1_2004_QTL2_peak_Bud_burst_3P Qrob_Chr02 2 s_1AW12F_382 s_1A77MR_223 42 6 64 lod 3,6 9,6
Bourran2_2003_QTL8_peak_Bud_burst_3P Qrob_Chr02 2 s_1ANG6_1446 v_11270_161 40 0 72 lod 4,4 9,9
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2015_nPriLBD_A4 Qrob_Chr02 2 s_1CP5DI_1183 s_1A63ZX_1277 24,87 24,63 26,18 lod 3.8 7
Bourran1_2003_QTL1_peak_Bud_burst_3P Qrob_Chr02 2 s_1AR8KI_1183 s_1B0QB1_473 22 6 41 lod 4,2 11,5
Bourran1_2004_QTL3_peak_Bud_burst_A4 Qrob_Chr02 2 s_1B0H8U_259 s_1CB1VL_554 17 0 46 lod 2,9 6,4
Bourran2_2015_nEpiBC_A4 Qrob_Chr07 7 s_1DP9TW_798 v_8128_173 22,61 22,14 22,73 lod 3.1 8.5
Champenoux_2015_nP_A4 Qrob_Chr02 2 s_1BN4CB_644 v_508_128 23,76 23,06 24,51 lod 2.8 6.2
Champenoux_2015_nPriLBD_A4 Qrob_Chr02 2 s_1CP5DI_1183 s_1A63ZX_1277 25,35 24,63 26,18 lod 4.0 8.7
Champenoux_2015_nSecLBD_A4 Qrob_Chr02 2 s_1AN4ZM_1665 v_8587_238 18,52 18,89 18,27 lod 3.2 7.4

1 Targeting

Analysis Start End Length Location Reliability Signal Peptide Cut Off Mitochondrion Cut Off Network Signal Peptide Length
TargetP 1 24   Secretory pathway 5 0.608 0.043 NON-PLANT 24