Protein : Qrob_P0243870.2 Q. robur
Protein Identifier  ? Qrob_P0243870.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=2) PTHR22958 - RELATED TO MULTIFUNCTIONAL CYCLIN-DEPENDENT KINASE-RELATED Code Enzyme  EC:3.1.4.46
Gene Prediction Quality  validated Protein length 

Sequence

Length: 389  
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
GO:0008081 phosphoric diester hydrolase activity Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.

35 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pop:POPTR_0001s13390g 1 388 + 388 Gaps:2 100.00 388 69.33 0.0 POPTRDRAFT_548064 hypothetical protein
blastp_kegg lcl|vvi:100261754 1 388 + 388 Gaps:6 100.00 382 69.90 0.0 glycerophosphodiester phosphodiesterase GDE1-like
blastp_kegg lcl|rcu:RCOM_1078720 1 365 + 365 Gaps:5 94.33 388 72.95 0.0 glycerophosphodiester phosphodiesterase putative
blastp_kegg lcl|pxb:103936100 1 387 + 387 Gaps:11 99.73 377 69.41 0.0 glycerophosphodiester phosphodiesterase GDE1-like
blastp_kegg lcl|pxb:103966565 1 387 + 387 Gaps:11 99.73 377 69.41 0.0 glycerophosphodiester phosphodiesterase GDE1-like
blastp_kegg lcl|pxb:103943629 1 387 + 387 Gaps:11 99.73 377 69.41 0.0 glycerophosphodiester phosphodiesterase GDE1-like
blastp_kegg lcl|mdm:103404157 1 387 + 387 Gaps:11 99.73 377 68.88 0.0 glycerophosphodiester phosphodiesterase GDE1-like
blastp_kegg lcl|pop:POPTR_0017s09050g 1 387 + 387 Gaps:6 99.74 382 67.72 0.0 hypothetical protein
blastp_kegg lcl|cit:102610916 1 366 + 366 Gaps:2 98.65 371 70.49 0.0 glycerophosphodiester phosphodiesterase GDE1-like
blastp_kegg lcl|mdm:103411114 1 387 + 387 Gaps:9 99.74 385 66.67 0.0 glycerophosphodiester phosphodiesterase gde1-like
blastp_pdb 3qvq_D 48 228 + 181 Gaps:44 56.75 252 34.27 1e-07 mol:protein length:252 Phosphodiesterase Olei02445
blastp_pdb 3qvq_C 48 228 + 181 Gaps:44 56.75 252 34.27 1e-07 mol:protein length:252 Phosphodiesterase Olei02445
blastp_pdb 3qvq_B 48 228 + 181 Gaps:44 56.75 252 34.27 1e-07 mol:protein length:252 Phosphodiesterase Olei02445
blastp_pdb 3qvq_A 48 228 + 181 Gaps:44 56.75 252 34.27 1e-07 mol:protein length:252 Phosphodiesterase Olei02445
blastp_uniprot_sprot sp|Q02979|GDE1_YEAST 53 340 + 288 Gaps:77 28.21 1223 34.20 3e-39 Glycerophosphodiester phosphodiesterase GDE1 OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN GDE1 PE 1 SV 1
blastp_uniprot_sprot sp|Q74ZH9|GDE1_ASHGO 53 350 + 298 Gaps:76 26.19 1321 32.95 4e-37 Glycerophosphodiester phosphodiesterase GDE1 OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) GN GDE1 PE 3 SV 2
blastp_uniprot_sprot sp|Q9C104|GDE1_SCHPO 53 342 + 290 Gaps:51 29.83 1076 32.71 2e-32 Glycerophosphodiester phosphodiesterase gde1 OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN gde1 PE 1 SV 1
blastp_uniprot_sprot sp|Q80VJ4|GPCP1_RAT 54 332 + 279 Gaps:32 43.30 672 30.58 7e-27 Glycerophosphocholine phosphodiesterase GPCPD1 OS Rattus norvegicus GN Gpcpd1 PE 2 SV 1
blastp_uniprot_sprot sp|Q8C0L9|GPCP1_MOUSE 54 332 + 279 Gaps:32 43.11 675 30.58 8e-27 Glycerophosphocholine phosphodiesterase GPCPD1 OS Mus musculus GN Gpcpd1 PE 1 SV 1
blastp_uniprot_sprot sp|Q9NPB8|GPCP1_HUMAN 54 332 + 279 Gaps:36 43.30 672 31.27 5e-26 Glycerophosphocholine phosphodiesterase GPCPD1 OS Homo sapiens GN GPCPD1 PE 1 SV 2
blastp_uniprot_sprot sp|Q10003|GPC1A_CAEEL 54 334 + 281 Gaps:52 38.07 796 30.36 3e-25 Putative glycerophosphocholine phosphodiesterase GPCPD1 homolog T05H10.7 OS Caenorhabditis elegans GN T05H10.7 PE 3 SV 1
blastp_uniprot_sprot sp|Q21407|GPC1B_CAEEL 50 356 + 307 Gaps:39 47.54 690 26.22 4e-18 Putative glycerophosphocholine phosphodiesterase GPCPD1 homolog K10B3.6 OS Caenorhabditis elegans GN K10B3.6 PE 3 SV 2
blastp_uniprot_sprot sp|O07592|YHDW_BACSU 53 330 + 278 Gaps:55 93.42 243 32.60 1e-06 Putative glycerophosphoryl diester phosphodiesterase YhdW OS Bacillus subtilis (strain 168) GN yhdW PE 3 SV 1
rpsblast_cdd gnl|CDD|176547 53 332 + 280 Gaps:1 99.65 282 51.60 1e-103 cd08605 GDPD_GDE5_like_1_plant Glycerophosphodiester phosphodiesterase domain of uncharacterized plant glycerophosphodiester phosphodiesterase-like proteins similar to mammalian GDE5. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in a group of uncharacterized plant glycerophosphodiester phosphodiesterase (GP-PDE)-like proteins. Members in this family show very high sequence homology to mammalian glycerophosphodiester phosphodiesterase GDE5 and are distantly related to plant GP-PDEs.
rpsblast_cdd gnl|CDD|176514 52 330 + 279 Gaps:18 99.32 293 41.58 2e-81 cd08572 GDPD_GDE5_like Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE5-like proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in mammalian glycerophosphodiester phosphodiesterase GDE5-like proteins. GDE5 is widely expressed in mammalian tissues with highest expression in spinal chord. Although its biological function remains unclear mammalian GDE5 shows higher sequence homology to fungal and plant glycerophosphodiester phosphodiesterases (GP-GDEs EC 3.1.4.46) than to other bacterial and mammalian GP-GDEs. It may also hydrolyze glycerophosphodiesters to sn-glycerol-3-phosphate (G3P) and the corresponding alcohols.
rpsblast_cdd gnl|CDD|176548 52 339 + 288 Gaps:24 98.60 286 40.07 1e-51 cd08606 GDPD_YPL110cp_fungi Glycerophosphodiester phosphodiesterase domain of Saccharomyces cerevisiae YPL110cp and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in Saccharomyces cerevisiae YPL110cp and other uncharacterized fungal homologs. The product of S. cerevisiae ORF YPL110c (GDE1) YPL110cp (Gde1p) displays homology to bacterial and mammalian glycerophosphodiester phosphodiesterases (GP-GDE EC 3.1.4.46) which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. S. cerevisiae YPL110cp has been characterized as a cytoplasmic glycerophosphocholine (GPC)-specific phosphodiesterase that selectively hydrolyzes GPC not glycerophosphoinositol (GPI) to generate choline and glycerolphosphate. YPL110cp has multi-domain architecture including not only C-terminal GDPD but also an SPX N-terminal domain along with several ankyrin repeats which implies that YPL110cp may mediate protein-protein interactions in a variety of proteins and play a role in maintaining cellular phosphate levels. Members in this family are distantly related to S. cerevisiae YPL206cp which selectively catalyzes the cleavage of phosphatidylglycerol (PG) not glycerophosphoinositol (GPI) or glycerophosphocholine (GPC) to diacylglycerol (DAG) and glycerophosphate and has been characterized as a PG-specific phospholipase C.
rpsblast_cdd gnl|CDD|176549 54 330 + 277 Gaps:49 98.62 290 31.47 3e-38 cd08607 GDPD_GDE5 Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in putative mammalian GDE5 and similar proteins. Mammalian GDE5 is widely expressed in mammalian tissues with highest expression in the spinal chord. Although its biological function remains unclear mammalian GDE5 shows higher sequence homology to fungal and plant glycerophosphodiester phosphodiesterases (GP-GDEs EC 3.1.4.46) than to other bacterial and mammalian GP-GDEs. It may also hydrolyze glycerophosphodiesters to sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. In addition to C-terminal GDPD domain all members in this subfamily have a starch binding domain (CBM20) in the N-terminus which suggests these proteins may play a distinct role in glycerol metabolism.
rpsblast_cdd gnl|CDD|202508 56 330 + 275 Gaps:45 98.32 238 34.19 1e-36 pfam03009 GDPD Glycerophosphoryl diester phosphodiesterase family. E. coli has two sequence related isozymes of glycerophosphoryl diester phosphodiesterase (GDPD) - periplasmic and cytosolic. This family also includes agrocinopine synthase the similarity to GDPD has been noted. This family appears to have weak but not significant matches to mammalian phospholipase C pfam00388 which suggests that this family may adopt a TIM barrel fold.
rpsblast_cdd gnl|CDD|30929 52 330 + 279 Gaps:46 93.00 257 26.78 3e-19 COG0584 UgpQ Glycerophosphoryl diester phosphodiesterase [Energy production and conversion].
rpsblast_cdd gnl|CDD|176499 53 330 + 278 Gaps:90 99.47 189 29.26 2e-14 cd08556 GDPD Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota and similar proteins. The typical glycerophosphodiester phosphodiesterase domain (GDPD) consists of a TIM barrel and a small insertion domain named the GDPD-insertion (GDPD-I) domain which is specific for GDPD proteins. This family corresponds to both typical GDPD domain and GDPD-like domain which lacks the GDPD-I region. Members in this family mainly consist of a large family of prokaryotic and eukaryotic glycerophosphodiester phosphodiesterases (GP-GDEs EC 3.1.4.46) and a number of uncharacterized homologs. Sphingomyelinases D (SMases D) (sphingomyelin phosphodiesterase D EC 3.1.4.41) from spider venom SMases D-like proteins and phospholipase D (PLD) from several pathogenic bacteria are also included in this family. GDPD plays an essential role in glycerol metabolism and catalyzes the hydrolysis of glycerophosphodiesters to sn-glycerol-3-phosphate (G3P) and the corresponding alcohols are major sources of carbon and phosphate. Its catalytic mechanism is based on the metal ion-dependent acid-base reaction which is similar to that of phosphoinositide-specific phospholipases C (PI-PLCs EC 3.1.4.11). Both GDPD related proteins and PI-PLCs belong to the superfamily of PI-PLC-like phosphodiesterases.

6 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Pfam 56 332 277 PF03009 none Glycerophosphoryl diester phosphodiesterase family IPR030395
Gene3D 49 336 288 G3DSA:3.20.20.190 none none IPR017946
PANTHER 51 362 312 PTHR22958 none none none
ProSiteProfiles 51 339 289 PS51704 none GP-PDE domain profile. IPR030395
SUPERFAMILY 49 140 92 SSF51695 none none IPR017946
SUPERFAMILY 169 333 165 SSF51695 none none IPR017946

0 Localization

0 Qtllist

0 Targeting