Protein : Qrob_P0226500.2 Q. robur
Protein Identifier  ? Qrob_P0226500.2 Organism . Name  Quercus robur
Score  91.1 Score Type  egn
Protein Description  (M=1) 2.5.1.46 - Deoxyhypusine synthase. Code Enzyme  EC:2.5.1.46
Gene Prediction Quality  validated Protein length 

Sequence

Length: 392  
Kegg Orthology  K00809
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0 Synonyms

1 GO Terms

Identifier Name Description
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine.

36 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|rcu:RCOM_0663340 11 388 + 378 Gaps:21 97.54 366 91.04 0.0 deoxyhypusine synthase putative (EC:2.5.1.45)
blastp_kegg lcl|cit:102616285 5 388 + 384 Gaps:21 98.64 368 88.43 0.0 deoxyhypusine synthase-like
blastp_kegg lcl|cic:CICLE_v10008698mg 5 388 + 384 Gaps:21 98.64 368 88.43 0.0 hypothetical protein
blastp_kegg lcl|pop:POPTR_0003s18570g 10 388 + 379 Gaps:21 97.55 367 87.43 0.0 POPTRDRAFT_831005 hypothetical protein
blastp_kegg lcl|tcc:TCM_042373 11 387 + 377 Gaps:21 97.27 366 86.52 0.0 Deoxyhypusine synthase isoform 1
blastp_kegg lcl|cmo:103503305 7 387 + 381 Gaps:22 97.04 372 85.60 0.0 deoxyhypusine synthase
blastp_kegg lcl|cam:101505901 1 389 + 389 Gaps:22 100.00 367 85.01 0.0 deoxyhypusine synthase-like
blastp_kegg lcl|pxb:103943952 10 382 + 373 Gaps:21 96.97 363 87.50 0.0 deoxyhypusine synthase
blastp_kegg lcl|gmx:100305453 1 389 + 389 Gaps:21 93.64 393 85.05 0.0 dhs1
blastp_kegg lcl|csv:101220126 10 391 + 382 Gaps:22 96.79 374 84.81 0.0 deoxyhypusine synthase-like
blastp_pdb 1rqd_B 17 391 + 375 Gaps:24 95.12 369 63.25 5e-160 mol:protein length:369 Deoxyhypusine synthase
blastp_pdb 1rqd_A 17 391 + 375 Gaps:24 95.12 369 63.25 5e-160 mol:protein length:369 Deoxyhypusine synthase
blastp_pdb 1roz_B 17 391 + 375 Gaps:24 95.12 369 63.25 5e-160 mol:protein length:369 Deoxyhypusine synthase
blastp_pdb 1roz_A 17 391 + 375 Gaps:24 95.12 369 63.25 5e-160 mol:protein length:369 Deoxyhypusine synthase
blastp_pdb 1rlz_A 17 391 + 375 Gaps:24 95.12 369 63.25 5e-160 mol:protein length:369 Deoxyhypusine synthase
blastp_pdb 1dhs_A 17 391 + 375 Gaps:24 97.23 361 63.25 7e-160 mol:protein length:361 DEOXYHYPUSINE SYNTHASE
blastp_uniprot_sprot sp|Q9FI94|DHYS_ARATH 7 387 + 381 Gaps:22 98.10 368 84.49 0.0 Deoxyhypusine synthase OS Arabidopsis thaliana GN DHS PE 2 SV 1
blastp_uniprot_sprot sp|Q6RJS2|DHYS_BRANA 5 387 + 383 Gaps:23 98.37 368 83.98 0.0 Deoxyhypusine synthase OS Brassica napus GN DHS PE 2 SV 1
blastp_uniprot_sprot sp|Q9SC14|DHYS_SENVE 1 387 + 387 Gaps:22 98.38 371 82.19 0.0 Deoxyhypusine synthase OS Senecio vernalis GN DHS1 PE 2 SV 1
blastp_uniprot_sprot sp|Q9AXR0|DHYS_SOLLC 1 390 + 390 Gaps:32 98.69 381 80.59 0.0 Deoxyhypusine synthase OS Solanum lycopersicum GN DHS PE 2 SV 1
blastp_uniprot_sprot sp|Q9AXQ8|DHYS_DIACA 12 387 + 376 Gaps:27 96.78 373 81.99 0.0 Deoxyhypusine synthase OS Dianthus caryophyllus GN DHS PE 2 SV 1
blastp_uniprot_sprot sp|Q9SC80|DHYS_TOBAC 5 388 + 384 Gaps:30 98.15 379 79.30 0.0 Deoxyhypusine synthase OS Nicotiana tabacum GN DHS1 PE 2 SV 1
blastp_uniprot_sprot sp|Q9AXQ9|DHYS_MUSAC 6 387 + 382 Gaps:22 96.28 376 75.41 0.0 Deoxyhypusine synthase OS Musa acuminata GN DHS PE 2 SV 1
blastp_uniprot_sprot sp|Q9SC13|HSS1_SENVE 1 387 + 387 Gaps:28 98.11 370 76.03 0.0 Homospermidine synthase 1 OS Senecio vernalis GN HSS1 PE 1 SV 1
blastp_uniprot_sprot sp|Q9M4B0|HSS1_SENVU 1 387 + 387 Gaps:28 98.11 370 75.76 0.0 Homospermidine synthase OS Senecio vulgaris GN HSS1 PE 1 SV 1
blastp_uniprot_sprot sp|P60038|HSS2_SENVE 1 387 + 387 Gaps:28 98.11 370 75.76 0.0 Homospermidine synthase 2 OS Senecio vernalis PE 1 SV 1
rpsblast_cdd gnl|CDD|145208 45 382 + 338 Gaps:42 99.66 297 61.82 1e-125 pfam01916 DS Deoxyhypusine synthase. Eukaryotic initiation factor 5A (eIF-5A) contains an unusual amino acid hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalyzed by the enzyme deoxyhypusine synthase (DS) EC:1.1.1.249. The modified version of eIF-5A and DS are required for eukaryotic cell proliferation.
rpsblast_cdd gnl|CDD|179688 12 381 + 370 Gaps:57 99.70 334 48.65 1e-100 PRK03971 PRK03971 putative deoxyhypusine synthase Provisional.
rpsblast_cdd gnl|CDD|32083 32 386 + 355 Gaps:55 96.86 318 47.73 6e-98 COG1899 DYS1 Deoxyhypusine synthase [Posttranslational modification protein turnover chaperones].
rpsblast_cdd gnl|CDD|161817 32 382 + 351 Gaps:52 100.00 301 49.50 2e-97 TIGR00321 dhys deoxyhypusine synthase. Deoxyhypusine synthase is responsible for the first step in creating hypusine. Hypusine is a modified amino acid found in eukaryotes and in archaea in their respective forms of initiation factor 5A. Its presence is confirmed in archaeal genera Pyrococcus Sulfolobus Halobacterium and Haloferax but in an older report was not detected in Methanococcus voltae (J Biol Chem 1987 Dec 5 262(34):16585-9). This family of apparent orthologs has an unusual UPGMA difference tree in which the members from the archaea M. jannaschii and P. horikoshii cluster with the known eukaryotic deoxyhypusine synthases. Separated by a fairly deep branch although still strongly related is a small cluster of proteins from Methanobacterium thermoautotrophicum and Archeoglobus fulgidus the latter of which has two.

6 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 32 389 358 G3DSA:3.40.910.10 "UniPathway:UPA00354" none IPR002773
SUPERFAMILY 12 387 376 SSF52467 none none IPR029035
Pfam 250 382 133 PF01916 "UniPathway:UPA00354" Deoxyhypusine synthase IPR002773
Pfam 45 231 187 PF01916 "UniPathway:UPA00354" Deoxyhypusine synthase IPR002773
PANTHER 251 382 132 PTHR11703 "UniPathway:UPA00354";signature_desc=DEOXYHYPUSINE SYNTHASE none IPR002773
PANTHER 3 229 227 PTHR11703 "UniPathway:UPA00354";signature_desc=DEOXYHYPUSINE SYNTHASE none IPR002773

0 Localization

8 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2003_QTL2_peak_Bud_burst_A4 Qrob_Chr02 2 s_1B0H8U_259 s_1CB1VL_554 17 0 87 lod 3,3 8,7
Bourran2_2004_QTL9_peak_Bud_burst_3P Qrob_Chr02 2 s_1C34E9_788 v_12238_322 50 25 75 lod 4,4 10,1
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL2_d13Cf Qrob_Chr02 2 s_1AQA4Z_1644 s_1AK5QX_947 53.67 14,01 79,68 lod 5.6594 0.03
Bourran1_2004_QTL2_peak_Bud_burst_3P Qrob_Chr02 2 s_1AW12F_382 s_1A77MR_223 42 6 64 lod 3,6 9,6
Bourran2_2002_QTL9_peak_Bud_burst_A4 Qrob_Chr02 2 s_1BFNDA_375 s_1A3VA1_2139 32,5 17 62 lod 3,1 4,2
Bourran2_2003_QTL8_peak_Bud_burst_3P Qrob_Chr02 2 s_1ANG6_1446 v_11270_161 40 0 72 lod 4,4 9,9
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL6_d13Cf Qrob_Chr02 2 s_1AEP21_172 v_6048_204 46.33 22,5 65,23 lod 4.972 0.03

0 Targeting