Protein : Qrob_P0226380.2 Q. robur
Protein Identifier  ? Qrob_P0226380.2 Organism . Name  Quercus robur
Score  77.0 Score Type  egn
Protein Description  (M=5) 3.1.1.4 - Phospholipase A(2). Code Enzyme  EC:3.1.1.4
Gene Prediction Quality  validated Protein length 

Sequence

Length: 149  
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0004623 phospholipase A2 activity Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
GO:0006644 phospholipid metabolic process The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.

27 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pmum:103340767 1 148 + 148 none 98.67 150 75.00 3e-77 probable phospholipase A2 homolog 1
blastp_kegg lcl|pper:PRUPE_ppa012884mg 1 148 + 148 none 98.67 150 74.32 3e-76 hypothetical protein
blastp_kegg lcl|fve:101309865 6 148 + 143 Gaps:1 98.63 146 78.47 3e-76 probable phospholipase A2 homolog 1-like
blastp_kegg lcl|mdm:103415844 1 148 + 148 none 98.01 151 72.97 3e-75 probable phospholipase A2 homolog 1
blastp_kegg lcl|mdm:103400757 1 148 + 148 none 98.01 151 72.97 3e-75 probable phospholipase A2 homolog 1
blastp_kegg lcl|pxb:103943955 1 148 + 148 none 98.01 151 72.30 6e-75 probable phospholipase A2 homolog 1
blastp_kegg lcl|mdm:103424185 1 148 + 148 none 98.01 151 71.62 2e-74 probable phospholipase A2 homolog 1
blastp_kegg lcl|cit:102618235 1 148 + 148 none 100.00 148 70.27 7e-73 probable phospholipase A2 homolog 1-like
blastp_kegg lcl|mdm:103453728 1 148 + 148 none 98.01 151 70.27 9e-73 probable phospholipase A2 homolog 1
blastp_kegg lcl|tcc:TCM_037706 1 148 + 148 Gaps:1 100.00 149 69.80 2e-72 Phospholipase A2 family protein
blastp_pdb 2wg8_A 36 147 + 112 Gaps:5 87.60 129 38.94 5e-20 mol:protein length:129 PUTATIVE PHOSPHOLIPASE A2
blastp_pdb 2wg8_C 39 147 + 109 Gaps:5 85.27 129 40.00 8e-20 mol:protein length:129 PUTATIVE PHOSPHOLIPASE A2
blastp_pdb 2wg8_B 39 147 + 109 Gaps:5 85.27 129 40.00 8e-20 mol:protein length:129 PUTATIVE PHOSPHOLIPASE A2
blastp_pdb 2wg9_B 39 147 + 109 Gaps:5 84.62 130 40.00 1e-19 mol:protein length:130 PUTATIVE PHOSPHOLIPASE A2
blastp_pdb 2wg9_A 39 147 + 109 Gaps:5 84.62 130 40.00 1e-19 mol:protein length:130 PUTATIVE PHOSPHOLIPASE A2
blastp_pdb 2wg7_B 39 147 + 109 Gaps:5 84.62 130 40.00 1e-19 mol:protein length:130 PUTATIVE PHOSPHOLIPASE A2
blastp_pdb 2wg7_A 39 147 + 109 Gaps:5 84.62 130 40.00 1e-19 mol:protein length:130 PUTATIVE PHOSPHOLIPASE A2
blastp_uniprot_sprot sp|Q9XG80|PLA21_ORYSJ 43 148 + 106 none 76.81 138 65.09 8e-49 Probable phospholipase A2 homolog 1 OS Oryza sativa subsp. japonica GN PLA2-I PE 2 SV 1
blastp_uniprot_sprot sp|Q8GZB4|PLA2B_ARATH 39 148 + 110 Gaps:7 79.59 147 58.12 5e-47 Phospholipase A2-beta OS Arabidopsis thaliana GN PLA2-BETA PE 1 SV 1
blastp_uniprot_sprot sp|Q9M0D7|PLA2C_ARATH 11 144 + 134 Gaps:13 71.12 187 53.38 1e-44 Phospholipase A2-gamma OS Arabidopsis thaliana GN PLA2-GAMMA PE 1 SV 1
blastp_uniprot_sprot sp|Q8GV50|PLA2D_ARATH 11 144 + 134 Gaps:13 69.63 191 51.88 4e-42 Phospholipase A2-delta OS Arabidopsis thaliana GN PLA2-DELTA PE 2 SV 1
blastp_uniprot_sprot sp|Q9XG81|PLA22_ORYSJ 39 147 + 109 Gaps:5 71.90 153 40.00 3e-19 Probable phospholipase A2 homolog 2 OS Oryza sativa subsp. japonica GN PLA2-II PE 1 SV 1
blastp_uniprot_sprot sp|Q10E50|PLA23_ORYSJ 39 143 + 105 Gaps:2 65.64 163 33.64 8e-18 Phospholipase A2 homolog 3 OS Oryza sativa subsp. japonica GN PLA2-III PE 1 SV 1
blastp_uniprot_sprot sp|Q8S8N6|PLA2A_ARATH 14 137 + 124 Gaps:14 93.24 148 31.88 1e-16 Phospholipase A2-alpha OS Arabidopsis thaliana GN PLA2-ALPHA PE 1 SV 1
blastp_uniprot_sprot sp|P00616|PA2TG_OXYSC 39 119 + 81 Gaps:18 41.45 152 44.44 9e-06 Acidic phospholipase A2 homolog taipoxin gamma chain OS Oxyuranus scutellatus scutellatus PE 1 SV 2
rpsblast_cdd gnl|CDD|153095 38 140 + 103 Gaps:4 91.45 117 43.93 2e-29 cd04706 PLA2_plant PLA2_plant: Plant-specific sub-family of Phospholipase A2 a super-family of secretory and cytosolic enzymes the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids secreted PLA2s have also been found to specifically bind to a variety of soluble and membrane proteins in mammals including receptors. As a toxin PLA2 is a potent presynaptic neurotoxin which blocks nerve terminals by binding to the nerve membrane and hydrolyzing stable membrane lipids. The products of the hydrolysis cannot form bilayers leading to a change in membrane conformation and ultimately to a block in the release of neurotransmitters. PLA2 may form dimers or oligomers. This sub-family does not appear to have a conserved active site and metal-binding loop.
rpsblast_cdd gnl|CDD|153092 53 103 + 51 none 61.45 83 31.37 2e-09 cd00618 PLA2_like PLA2_like: Phospholipase A2 a super-family of secretory and cytosolic enzymes the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine) usually in a metal-dependent reaction to generate lysophospholipid (LysoPL) and a free fatty acid (FA). The resulting products are either dietary or used in synthetic pathways for leukotrienes and prostaglandins. Often arachidonic acid is released as a free fatty acid and acts as second messenger in signaling networks. Secreted PLA2s have also been found to specifically bind to a variety of soluble and membrane proteins in mammals including receptors. As a toxin PLA2 is a potent presynaptic neurotoxin which blocks nerve terminals by binding to the nerve membrane and hydrolyzing stable membrane lipids. The products of the hydrolysis (LysoPL and FA) cannot form bilayers leading to a change in membrane conformation and ultimately to a block in the release of neurotransmitters. PLA2 may form dimers or oligomers.

8 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
ProSitePatterns 78 85 8 PS00118 "KEGG:00564+3.1.1.4","KEGG:00565+3.1.1.4","KEGG:00590+3.1.1.4","KEGG:00591+3.1.1.4","KEGG:00592+3.1.1.4","MetaCyc:PWY-6803","MetaCyc:PWY-7409","MetaCyc:PWY-7416","MetaCyc:PWY-7417" Phospholipase A2 histidine active site. IPR013090
Phobius 25 28 4 SIGNAL_PEPTIDE_C_REGION none C-terminal region of a signal peptide. none
Phobius 1 12 12 SIGNAL_PEPTIDE_N_REGION none N-terminal region of a signal peptide. none
SUPERFAMILY 53 112 60 SSF48619 "KEGG:00564+3.1.1.4","KEGG:00565+3.1.1.4","KEGG:00590+3.1.1.4","KEGG:00591+3.1.1.4","KEGG:00592+3.1.1.4","MetaCyc:PWY-6803","MetaCyc:PWY-7409","MetaCyc:PWY-7416","MetaCyc:PWY-7417" none IPR016090
Phobius 1 28 28 SIGNAL_PEPTIDE none Signal peptide region none
Phobius 29 148 120 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Gene3D 43 105 63 G3DSA:1.20.90.10 "KEGG:00564+3.1.1.4","KEGG:00565+3.1.1.4","KEGG:00590+3.1.1.4","KEGG:00591+3.1.1.4","KEGG:00592+3.1.1.4","MetaCyc:PWY-6803","MetaCyc:PWY-7409","MetaCyc:PWY-7416","MetaCyc:PWY-7417" none IPR016090
Phobius 13 24 12 SIGNAL_PEPTIDE_H_REGION none Hydrophobic region of a signal peptide. none

3 Localization

Analysis Start End Length
SignalP_GRAM_POSITIVE 1 30 29
TMHMM 10 32 22
SignalP_EUK 1 30 29

8 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran1_2003_QTL2_peak_Bud_burst_A4 Qrob_Chr02 2 s_1B0H8U_259 s_1CB1VL_554 17 0 87 lod 3,3 8,7
Bourran2_2004_QTL9_peak_Bud_burst_3P Qrob_Chr02 2 s_1C34E9_788 v_12238_322 50 25 75 lod 4,4 10,1
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL2_d13Cf Qrob_Chr02 2 s_1AQA4Z_1644 s_1AK5QX_947 53.67 14,01 79,68 lod 5.6594 0.03
Bourran1_2004_QTL2_peak_Bud_burst_3P Qrob_Chr02 2 s_1AW12F_382 s_1A77MR_223 42 6 64 lod 3,6 9,6
Bourran2_2002_QTL9_peak_Bud_burst_A4 Qrob_Chr02 2 s_1BFNDA_375 s_1A3VA1_2139 32,5 17 62 lod 3,1 4,2
Bourran2_2003_QTL8_peak_Bud_burst_3P Qrob_Chr02 2 s_1ANG6_1446 v_11270_161 40 0 72 lod 4,4 9,9
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL6_d13Cf Qrob_Chr02 2 s_1AEP21_172 v_6048_204 46.33 22,5 65,23 lod 4.972 0.03

0 Targeting