Protein : Qrob_P0210180.2 Q. robur
Protein Identifier  ? Qrob_P0210180.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=1) 3.5.4.25//4.1.99.12 - GTP cyclohydrolase II. // 3,4-dihydroxy-2-butanone-4-phosphate synthase. Code Enzyme  EC:4.1.99.12, EC:3.5.4.25
Gene Prediction Quality  validated Protein length 

Sequence

Length: 219  
Kegg Orthology  K14652
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
GO:0003935 GTP cyclohydrolase II activity Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+).

34 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|cic:CICLE_v10025787mg 29 218 + 190 Gaps:2 47.47 396 87.23 5e-111 hypothetical protein
blastp_kegg lcl|cit:102626341 29 218 + 190 Gaps:2 35.14 535 86.17 9e-108 bifunctional riboflavin biosynthesis protein RIBA 1 chloroplastic-like
blastp_kegg lcl|pop:POPTR_0007s04980g 29 218 + 190 Gaps:2 35.54 529 84.57 5e-107 POPTRDRAFT_217377 hypothetical protein
blastp_kegg lcl|mdm:103443270 27 196 + 170 none 80.57 211 88.24 2e-106 bifunctional riboflavin biosynthesis protein RIBA 1 chloroplastic-like
blastp_kegg lcl|atr:s00008p00210700 29 216 + 188 Gaps:2 32.92 565 84.41 1e-105 AMTR_s00008p00210700 hypothetical protein
blastp_kegg lcl|tcc:TCM_007420 29 218 + 190 Gaps:4 33.16 561 86.56 5e-105 GTP cyclohydrolase II isoform 1
blastp_kegg lcl|pop:POPTR_0001s31800g 29 205 + 177 Gaps:2 34.72 504 87.43 9e-105 hypothetical protein
blastp_kegg lcl|mdm:103437501 29 197 + 169 none 31.35 539 89.94 3e-104 bifunctional riboflavin biosynthesis protein RIBA 1 chloroplastic-like
blastp_kegg lcl|pxb:103955643 29 215 + 187 Gaps:2 34.32 539 84.32 7e-104 bifunctional riboflavin biosynthesis protein RIBA 1 chloroplastic-like
blastp_kegg lcl|fve:101309087 29 195 + 167 none 31.10 537 91.02 2e-103 riboflavin biosynthesis protein ribBA chloroplastic-like
blastp_pdb 2bz1_A 29 185 + 157 Gaps:1 79.59 196 52.56 3e-46 mol:protein length:196 GTP CYCLOHYDROLASE II
blastp_pdb 2bz0_B 29 185 + 157 Gaps:1 79.59 196 52.56 3e-46 mol:protein length:196 GTP CYCLOHYDROLASE II
blastp_pdb 2bz0_A 29 185 + 157 Gaps:1 79.59 196 52.56 3e-46 mol:protein length:196 GTP CYCLOHYDROLASE II
blastp_uniprot_sprot sp|P47924|RIBA1_ARATH 29 194 + 166 none 30.57 543 88.55 6e-101 Bifunctional riboflavin biosynthesis protein RIBA 1 chloroplastic OS Arabidopsis thaliana GN RIBA1 PE 1 SV 2
blastp_uniprot_sprot sp|Q6Z234|RIBA1_ORYSJ 29 195 + 167 none 31.04 538 85.03 8e-99 Probable bifunctional riboflavin biosynthesis protein RIBA 1 chloroplastic OS Oryza sativa subsp. japonica GN RIBA1 PE 2 SV 1
blastp_uniprot_sprot sp|Q0E079|RIBA2_ORYSJ 29 203 + 175 Gaps:3 32.19 553 82.02 4e-97 Probable bifunctional riboflavin biosynthesis protein RIBA 2 chloroplastic OS Oryza sativa subsp. japonica GN RIBA2 PE 2 SV 1
blastp_uniprot_sprot sp|Q9FN89|RIBA3_ARATH 29 191 + 163 none 32.02 509 80.98 2e-91 Monofunctional riboflavin biosynthesis protein RIBA 3 chloroplastic OS Arabidopsis thaliana GN RIBA3 PE 1 SV 1
blastp_uniprot_sprot sp|Q6L506|RIBA3_ORYSJ 29 194 + 166 none 30.97 536 79.52 5e-91 Probable monofunctional riboflavin biosynthesis protein RIBA 3 chloroplastic OS Oryza sativa subsp. japonica GN RIBA3 PE 2 SV 1
blastp_uniprot_sprot sp|A4X639|RIBBA_SALTO 21 187 + 167 none 41.75 400 65.87 5e-71 Riboflavin biosynthesis protein RibBA OS Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440) GN ribBA PE 3 SV 1
blastp_uniprot_sprot sp|Q5YTP3|RIBBA_NOCFA 29 184 + 156 none 37.68 414 67.31 1e-70 Riboflavin biosynthesis protein RibBA OS Nocardia farcinica (strain IFM 10152) GN ribBA PE 3 SV 1
blastp_uniprot_sprot sp|A8LY38|RIBBA_SALAI 21 185 + 165 none 39.29 420 65.45 5e-69 Riboflavin biosynthesis protein RibBA OS Salinispora arenicola (strain CNS-205) GN ribBA PE 3 SV 1
blastp_uniprot_sprot sp|Q741F1|RIBBA_MYCPA 13 190 + 178 Gaps:3 41.65 425 63.84 6e-69 Riboflavin biosynthesis protein RibBA OS Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) GN ribBA PE 3 SV 1
blastp_uniprot_sprot sp|A0QI09|RIBBA_MYCA1 13 190 + 178 Gaps:3 41.65 425 63.28 2e-68 Riboflavin biosynthesis protein RibBA OS Mycobacterium avium (strain 104) GN ribBA PE 3 SV 1
rpsblast_cdd gnl|CDD|178425 29 203 + 175 none 38.89 450 84.57 1e-100 PLN02831 PLN02831 Bifunctional GTP cyclohydrolase II/ 3 4-dihydroxy-2-butanone-4-phosphate synthase.
rpsblast_cdd gnl|CDD|181774 29 184 + 156 none 38.81 402 67.31 4e-84 PRK09311 PRK09311 bifunctional 3 4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein Provisional.
rpsblast_cdd gnl|CDD|88311 29 185 + 157 Gaps:1 80.83 193 63.46 6e-66 cd00641 GTP_cyclohydro2 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2 5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate formate pyrophosphate (APy) and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the precursor molecule for the synthesis of the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) which are essential to cell metabolism. The enzyme is present in plants and numerous pathogenic bacteria especially gram negative organisms who are dependent on endogenous synthesis of the vitamin because they lack an appropriate uptake system. For animals and humans which lack this biosynthetic pathway riboflavin is the essential vitamin B2. GTP cyclohydrolase II requires magnesium ions for activity and has a bound catalytic zinc. The functionally active form is thought to be a homodimer. A paralogous protein is encoded in the genome of Streptomyces coelicolor which converts GTP to 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (FAPy) an activity that has otherwise been reported for unrelated GTP cyclohydrolases III..
rpsblast_cdd gnl|CDD|181777 35 185 + 151 Gaps:1 27.03 555 62.67 9e-64 PRK09319 PRK09319 bifunctional 3 4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein Provisional.
rpsblast_cdd gnl|CDD|178999 27 189 + 163 Gaps:1 82.23 197 53.70 2e-63 PRK00393 ribA GTP cyclohydrolase II Reviewed.
rpsblast_cdd gnl|CDD|201507 29 163 + 135 Gaps:1 79.29 169 67.91 3e-59 pfam00925 GTP_cyclohydro2 GTP cyclohydrolase II. GTP cyclohydrolase II catalyzes the first committed step in the biosynthesis of riboflavin.
rpsblast_cdd gnl|CDD|31150 33 184 + 152 Gaps:1 78.24 193 60.26 6e-56 COG0807 RibA GTP cyclohydrolase II [Coenzyme metabolism].

5 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PANTHER 34 211 178 PTHR21327 none none none
Pfam 17 163 147 PF00925 "KEGG:00740+3.5.4.25","MetaCyc:PWY-6168","MetaCyc:PWY-7539","UniPathway:UPA00275" GTP cyclohydrolase II IPR000926
SUPERFAMILY 28 164 137 SSF142695 none none none
PANTHER 34 211 178 PTHR21327:SF7 none none none
TIGRFAM 29 185 157 TIGR00505 "KEGG:00740+3.5.4.25","MetaCyc:PWY-6168","MetaCyc:PWY-7539","UniPathway:UPA00275" ribA: GTP cyclohydrolase II IPR000926

0 Localization

0 Qtllist

0 Targeting