Protein : Qrob_P0188670.2 Q. robur
Protein Identifier  ? Qrob_P0188670.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=2) 1.13.11.27 - 4-hydroxyphenylpyruvate dioxygenase. Code Enzyme  EC:1.13.11.27
Gene Prediction Quality  validated Protein length 

Sequence

Length: 168  
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0 Synonyms

4 GO Terms

Identifier Name Description
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
GO:0009072 aromatic amino acid family metabolic process The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor.

27 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100248785 1 162 + 162 Gaps:73 52.01 448 43.35 2e-46 4-hydroxyphenylpyruvate dioxygenase-like
blastp_kegg lcl|rcu:RCOM_1192240 1 162 + 162 Gaps:67 51.47 441 44.49 4e-46 4-hydroxyphenylpyruvate dioxygenase putative (EC:1.13.11.27)
blastp_kegg lcl|cic:CICLE_v10031587mg 2 162 + 161 Gaps:67 52.07 434 43.81 5e-46 hypothetical protein
blastp_kegg lcl|cit:102618830 2 162 + 161 Gaps:67 52.07 434 43.81 5e-46 4-hydroxyphenylpyruvate dioxygenase-like
blastp_kegg lcl|tcc:TCM_001963 1 162 + 162 Gaps:68 51.94 439 42.98 2e-43 Phytoene desaturation 1 isoform 1
blastp_kegg lcl|csv:101215051 3 162 + 160 Gaps:75 51.21 455 43.35 4e-43 4-hydroxyphenylpyruvate dioxygenase-like
blastp_kegg lcl|cmo:103504117 2 162 + 161 Gaps:79 50.11 467 43.16 4e-43 4-hydroxyphenylpyruvate dioxygenase
blastp_kegg lcl|sot:102595018 3 162 + 160 Gaps:66 51.13 442 42.04 4e-43 4-hydroxyphenylpyruvate dioxygenase-like
blastp_kegg lcl|sly:101257377 1 162 + 162 Gaps:66 51.70 441 41.23 5e-43 4-hydroxyphenylpyruvate dioxygenase-like
blastp_kegg lcl|pop:POPTR_0002s05840g 1 162 + 162 Gaps:72 52.25 444 41.38 2e-42 POPTRDRAFT_798588 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE family protein
blastp_pdb 1sp9_B 1 162 + 162 Gaps:70 51.24 445 39.47 8e-41 mol:protein length:445 4-hydroxyphenylpyruvate dioxygenase
blastp_pdb 1sp9_A 1 162 + 162 Gaps:70 51.24 445 39.47 8e-41 mol:protein length:445 4-hydroxyphenylpyruvate dioxygenase
blastp_pdb 1tg5_A 1 162 + 162 Gaps:70 53.77 424 39.47 1e-40 mol:protein length:424 4-hydroxyphenylpyruvate dioxygenase
blastp_pdb 1tfz_A 1 162 + 162 Gaps:70 53.77 424 39.47 1e-40 mol:protein length:424 4-hydroxyphenylpyruvate dioxygenase
blastp_pdb 1sqd_A 1 162 + 162 Gaps:70 53.77 424 39.47 1e-40 mol:protein length:424 4-hydroxyphenylpyruvate dioxygenase
blastp_pdb 1sp8_D 1 162 + 162 Gaps:69 53.83 418 33.78 2e-28 mol:protein length:418 4-Hydroxyphenylpyruvate Dioxygenase
blastp_pdb 1sp8_C 1 162 + 162 Gaps:69 53.83 418 33.78 2e-28 mol:protein length:418 4-Hydroxyphenylpyruvate Dioxygenase
blastp_pdb 1sp8_B 1 162 + 162 Gaps:69 53.83 418 33.78 2e-28 mol:protein length:418 4-Hydroxyphenylpyruvate Dioxygenase
blastp_pdb 1sp8_A 1 162 + 162 Gaps:69 53.83 418 33.78 2e-28 mol:protein length:418 4-Hydroxyphenylpyruvate Dioxygenase
blastp_uniprot_sprot sp|O23920|HPPD_DAUCA 1 162 + 162 Gaps:64 51.13 442 41.59 8e-43 4-hydroxyphenylpyruvate dioxygenase OS Daucus carota PE 2 SV 1
blastp_uniprot_sprot sp|P93836|HPPD_ARATH 1 162 + 162 Gaps:70 51.24 445 39.47 3e-40 4-hydroxyphenylpyruvate dioxygenase OS Arabidopsis thaliana GN HPD PE 1 SV 2
blastp_uniprot_sprot sp|Q9ARF9|HPPD_PLESU 26 162 + 137 Gaps:45 41.28 436 44.44 5e-35 4-hydroxyphenylpyruvate dioxygenase OS Plectranthus scutellarioides PE 2 SV 1
blastp_uniprot_sprot sp|O48604|HPPD_HORVU 1 162 + 162 Gaps:70 51.61 434 33.93 1e-26 4-hydroxyphenylpyruvate dioxygenase OS Hordeum vulgare PE 2 SV 1
rpsblast_cdd gnl|CDD|178463 3 167 + 165 Gaps:75 59.80 398 39.08 2e-43 PLN02875 PLN02875 4-hydroxyphenylpyruvate dioxygenase.
rpsblast_cdd gnl|CDD|162275 3 161 + 159 Gaps:67 61.76 353 20.64 2e-12 TIGR01263 4HPPD 4-hydroxyphenylpyruvate dioxygenase. This protein oxidizes 4-hydroxyphenylpyruvate a tyrosine and phenylalanine catabolite to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerization into brown pigments that protect some bacterial species from light. A similar process occurs spontaneously in blood and is hemolytic. In some bacterial species this enzyme has been studied as a hemolysin.
rpsblast_cdd gnl|CDD|176673 61 167 + 107 Gaps:47 77.49 191 27.03 2e-08 cd07250 HPPD_C_like C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS). HppD and HmaS are non-heme iron-dependent dioxygenases which modify a common substrate 4-hydroxyphenylpyruvate (HPP) but yield different products. HPPD catalyzes the second reaction in tyrosine catabolism the conversion of 4-hydroxyphenylpyruvate to homogentisate (2 5-dihydroxyphenylacetic acid HG). HmaS converts HPP to 4-hydroxymandelate a committed step in the formation of hydroxyphenylglycerine a structural component of nonproteinogenic macrocyclic peptide antibiotics such as vancomycin. If the emphasis is on catalytic chemistry HPPD and HmaS are classified as members of a large family of alpha-keto acid dependent mononuclear non-heme iron oxygenases most of which require Fe(II) molecular oxygen and an alpha-keto acid (typically alpha-ketoglutarate) to either oxygenate or oxidize a third substrate. Both enzymes are exceptions in that they require two instead of three substrates do not use alpha-ketoglutarate and incorporate both atoms of dioxygen into the aromatic product. Both HPPD and HmaS exhibit duplicate beta barrel topology in their N- and C-terminal domains which share sequence similarity suggestive of a gene duplication. Each protein has only one catalytic site located in at the C-terminal domain. This HPPD_C_like domain represents the C-terminal domain.
rpsblast_kog gnl|CDD|35857 3 161 + 159 Gaps:69 59.32 381 24.78 1e-18 KOG0638 KOG0638 KOG0638 4-hydroxyphenylpyruvate dioxygenase [Amino acid transport and metabolism].

4 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 61 125 65 G3DSA:3.10.180.10 none none IPR029068
PANTHER 40 124 85 PTHR11959:SF1 none none none
PANTHER 40 124 85 PTHR11959 none none IPR005956
SUPERFAMILY 2 156 155 SSF54593 none none IPR029068

0 Localization

0 Qtllist

0 Targeting