Protein : Qrob_P0165790.2 Q. robur
Protein Identifier  ? Qrob_P0165790.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=25) K05387 - glutamate receptor, ionotropic, other eukaryote Gene Prediction Quality  validated
Protein length 

Sequence

Length: 494  
Kegg Orthology  K05387
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0 Synonyms

2 GO Terms

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0004970 ionotropic glutamate receptor activity Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.

32 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pop:POPTR_0017s09310g 1 474 + 474 Gaps:62 78.41 681 55.43 0.0 hypothetical protein
blastp_kegg lcl|rcu:RCOM_0919920 1 472 + 472 Gaps:63 57.04 931 56.12 0.0 glutamate receptor 2 plant putative
blastp_kegg lcl|pmum:103320895 1 472 + 472 Gaps:62 56.44 939 56.79 0.0 glutamate receptor 2.8-like
blastp_kegg lcl|rcu:RCOM_0919910 2 472 + 471 Gaps:63 55.15 961 56.23 0.0 glutamate receptor 2 plant putative
blastp_kegg lcl|pper:PRUPE_ppa022588mg 1 472 + 472 Gaps:62 56.44 939 56.42 0.0 hypothetical protein
blastp_kegg lcl|pop:POPTR_0017s09420g 2 475 + 474 Gaps:71 64.64 840 53.96 0.0 hypothetical protein
blastp_kegg lcl|rcu:RCOM_0919660 1 470 + 470 Gaps:63 54.48 971 54.82 0.0 glutamate receptor 2 plant putative
blastp_kegg lcl|tcc:TCM_036849 1 472 + 472 Gaps:62 53.70 987 55.66 0.0 Glutamate receptor 2.9
blastp_kegg lcl|pper:PRUPE_ppa017927mg 1 474 + 474 Gaps:63 58.38 913 54.97 0.0 hypothetical protein
blastp_kegg lcl|pop:POPTR_0018s03190g 1 472 + 472 Gaps:61 63.44 837 54.43 0.0 hypothetical protein
blastp_pdb 3kg2_D 204 440 + 237 Gaps:35 25.27 823 24.04 6e-07 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3kg2_C 204 440 + 237 Gaps:35 25.27 823 24.04 6e-07 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3kg2_B 204 440 + 237 Gaps:35 25.27 823 24.04 6e-07 mol:protein length:823 Glutamate receptor 2
blastp_pdb 3kg2_A 204 440 + 237 Gaps:35 25.27 823 24.04 6e-07 mol:protein length:823 Glutamate receptor 2
blastp_uniprot_sprot sp|Q8LGN0|GLR27_ARATH 1 470 + 470 Gaps:67 54.31 952 47.97 3e-157 Glutamate receptor 2.7 OS Arabidopsis thaliana GN GLR2.7 PE 2 SV 3
blastp_uniprot_sprot sp|Q9SHV1|GLR22_ARATH 1 472 + 472 Gaps:56 56.96 920 43.89 2e-156 Glutamate receptor 2.2 OS Arabidopsis thaliana GN GLR2.2 PE 2 SV 1
blastp_uniprot_sprot sp|Q9C5V5|GLR28_ARATH 1 472 + 472 Gaps:64 54.91 947 48.08 1e-152 Glutamate receptor 2.8 OS Arabidopsis thaliana GN GLR2.8 PE 2 SV 2
blastp_uniprot_sprot sp|Q9SHV2|GLR23_ARATH 1 472 + 472 Gaps:57 58.66 895 42.10 3e-148 Glutamate receptor 2.3 OS Arabidopsis thaliana GN GLR2.3 PE 2 SV 1
blastp_uniprot_sprot sp|O81078|GLR29_ARATH 1 472 + 472 Gaps:72 54.47 940 46.88 3e-147 Glutamate receptor 2.9 OS Arabidopsis thaliana GN GLR2.9 PE 2 SV 1
blastp_uniprot_sprot sp|Q9LFN5|GLR25_ARATH 1 483 + 483 Gaps:66 58.71 918 43.60 9e-147 Glutamate receptor 2.5 OS Arabidopsis thaliana GN GLR2.5 PE 2 SV 2
blastp_uniprot_sprot sp|Q9LFN8|GLR26_ARATH 1 480 + 480 Gaps:67 54.91 967 43.69 5e-144 Glutamate receptor 2.6 OS Arabidopsis thaliana GN GLR2.6 PE 2 SV 2
blastp_uniprot_sprot sp|O04660|GLR21_ARATH 1 472 + 472 Gaps:62 57.49 901 42.47 8e-143 Glutamate receptor 2.1 OS Arabidopsis thaliana GN GLR2.1 PE 2 SV 2
blastp_uniprot_sprot sp|O81776|GLR24_ARATH 1 472 + 472 Gaps:71 56.81 896 41.45 8e-129 Glutamate receptor 2.4 OS Arabidopsis thaliana GN GLR2.4 PE 2 SV 2
blastp_uniprot_sprot sp|Q9C8E7|GLR33_ARATH 3 480 + 478 Gaps:85 57.13 933 30.96 6e-77 Glutamate receptor 3.3 OS Arabidopsis thaliana GN GLR3.3 PE 2 SV 1
rpsblast_cdd gnl|CDD|107361 1 256 + 256 Gaps:66 78.29 350 29.56 4e-43 cd06366 PBP1_GABAb_receptor Ligand-binding domain of GABAb receptors which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). Ligand-binding domain of GABAb receptors which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and like glutamate and other transmitters acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha_i proteins and activation causes a decrease in calcium an increase in potassium membrane conductance and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release for example.
rpsblast_cdd gnl|CDD|201592 1 236 + 236 Gaps:61 82.51 343 21.91 5e-23 pfam01094 ANF_receptor Receptor family ligand binding region. This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.
rpsblast_cdd gnl|CDD|153138 2 158 + 157 Gaps:43 54.60 348 22.11 2e-21 cd06350 PBP1_GPCR_family_C_like Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The metabotropic glutamate receptors (mGluR) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. The mGluRs are coupled to G proteins and are thus distinct from the iGluRs which internally contain ligand-gated ion channels. The mGluR structure is divided into three regions: the extracellular region the seven-spanning transmembrane region and the cytoplasmic region. The extracellular region is further devided into the ligand-binding domain (LBD) and the cysteine-rich domain. The LBD has sequence similarity to the LIVBP which is a bacterial periplasmic protein (PBP) as well as to the extracellular region of both iGluR and the gamma-aminobutyric acid (GABA)b receptor. iGluRs are divided into three main subtypes based on pharmacological profile: NMDA AMPA and kainate receptors. All family C GPCRs have a large extracellular N terminus that contain a domain with homology to bacterial periplasmic amino acid-binding proteins.
rpsblast_cdd gnl|CDD|153137 3 139 + 137 Gaps:41 56.38 298 22.02 2e-14 cd06269 PBP1_glutamate_receptors_like Family C G-protein couples receptors (GPCRs) membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs) and the N-terminal leucine/isoleucine/valine- binding protein (LIVBP)-like domain of the ionotropic glutamate receptors. This CD represents the ligand-binding domain of the family C G-protein couples receptors (GPCRs) membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs) and the N-terminal leucine/isoleucine/valine- binding protein (LIVBP)-like domain of the ionotropic glutamate receptors all of which are structurally similar and related to the periplasmic-binding fold type I family. The family C GPCRs consist of metabotropic glutamate receptor (mGluR) receptors a calcium-sensing receptor (CaSR) gamma-aminobutyric receptors (GABAb) the promiscuous L-alpha-amino acid receptor GPR6A families of taste and pheromone receptors and orphan receptors. Truncated splicing variants of the orphan receptors are not included in this CD. The family C GPCRs are activated by endogenous agonists such as amino acids ions and sugar based molecules. Their amino terminal ligand-binding region is homologous to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). The ionotropic glutamate receptors (iGluRs) have an integral ion channel and are subdivided into three major groups based on their pharmacology and structural similarities: NMDA receptors AMPA receptors and kainate receptors. The family of membrane bound guanylyl cyclases is further divided into three subfamilies: the ANP receptor (GC-A)/C-type natriuretic peptide receptor (GC-B) the heat-stable enterotoxin receptor (GC-C)/sensory organ specific membrane GCs such as retinal receptors (GC-E GC-F) and olfactory receptors (GC-D and GC-G).
rpsblast_cdd gnl|CDD|107263 11 83 + 73 Gaps:1 24.83 298 33.78 6e-09 cd06268 PBP1_ABC_transporter_LIVBP_like Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily. Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily. They are mostly present in archaea and eubacteria and are primarily involved in scavenging solutes from the environment. ABC-type transporters couple ATP hydrolysis with the uptake and efflux of a wide range of substrates across bacterial membranes including amino acids peptides lipids and sterols and various drugs. These systems are comprised of transmembrane domains nucleotide binding domains and in most bacterial uptake systems periplasmic binding proteins (PBPs) which transfer the ligand to the extracellular gate of the transmembrane domains. These PBPs bind their substrates selectively and with high affinity. Members of this group include ABC-type Leucine-Isoleucine-Valine-Binding Proteins (LIVBP) which are homologous to the aliphatic amidase transcriptional repressor AmiC of Pseudomonas aeruginosa. The uncharacterized periplasmic components of various ABC-type transport systems are included in this group.
rpsblast_cdd gnl|CDD|189368 424 472 + 49 Gaps:4 19.78 268 28.30 3e-08 pfam00060 Lig_chan Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.

19 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 1 422 422 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
SUPERFAMILY 276 288 13 SSF53822 none none IPR028082
SUPERFAMILY 5 247 243 SSF53822 none none IPR028082
SMART 295 474 180 SM00079 none Eukaryotic homologues of bacterial periplasmic substrate binding proteins. IPR001320
Phobius 444 462 19 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 486 493 8 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Gene3D 292 452 161 G3DSA:3.40.190.10 none none none
PANTHER 276 471 196 PTHR18966 none none none
PANTHER 1 252 252 PTHR18966 none none none
Gene3D 11 92 82 G3DSA:3.40.50.2300 none none none
Pfam 422 471 50 PF00060 none Ligand-gated ion channel IPR001320
Pfam 323 409 87 PF00497 none Bacterial extracellular solute-binding proteins, family 3 none
SUPERFAMILY 272 428 157 SSF53850 none none none
PANTHER 276 471 196 PTHR18966:SF6 none none none
PANTHER 1 252 252 PTHR18966:SF6 none none none
Phobius 423 443 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 463 485 23 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Pfam 92 171 80 PF01094 none Receptor family ligand binding region IPR001828
Pfam 3 84 82 PF01094 none Receptor family ligand binding region IPR001828

1 Localization

Analysis Start End Length
TMHMM 426 443 17

2 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2014_rEpiBC_3P Qrob_Chr05 5 s_2GDU0O_517 s_1BT8O3_239 25,81 0 55,45 lod 2,2101 5,5

0 Targeting