Protein : Qrob_P0080990.2 Q. robur
Protein Identifier  ? Qrob_P0080990.2 Organism . Name  Quercus robur
Score  34.2 Score Type  egn
Protein Description  (M=18) K04567 - lysyl-tRNA synthetase, class II [EC:6.1.1.6] Code Enzyme  EC:6.1.1.6
Gene Prediction Quality  validated Protein length 

Sequence

Length: 185  
Kegg Orthology  K04567
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0 Synonyms

5 GO Terms

Identifier Name Description
GO:0003676 nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
GO:0005524 ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO:0000166 nucleotide binding Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
GO:0004812 aminoacyl-tRNA ligase activity Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.
GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis.

35 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|cit:102615402 1 183 + 183 Gaps:20 30.88 651 59.70 2e-65 lysine--tRNA ligase-like
blastp_kegg lcl|tcc:TCM_019889 1 183 + 183 Gaps:11 31.65 613 60.31 2e-64 Lysyl-tRNA synthetase 1 isoform 1
blastp_kegg lcl|vvi:100242505 45 183 + 139 none 22.42 620 74.10 2e-64 lysyl-tRNA synthetase-like
blastp_kegg lcl|vvi:100262532 45 183 + 139 none 22.46 619 74.10 5e-64 lysyl-tRNA synthetase-like
blastp_kegg lcl|brp:103846034 1 183 + 183 Gaps:12 31.55 618 58.46 1e-63 lysine--tRNA ligase
blastp_kegg lcl|eus:EUTSA_v10020276mg 51 183 + 133 none 21.56 617 74.44 2e-62 hypothetical protein
blastp_kegg lcl|rcu:RCOM_0435350 1 183 + 183 Gaps:13 31.30 607 60.53 4e-62 lysyl-tRNA synthetase putative (EC:6.1.1.6)
blastp_kegg lcl|brp:103859404 1 183 + 183 Gaps:17 32.04 618 55.56 6e-61 lysine--tRNA ligase-like
blastp_kegg lcl|gmx:100809106 44 183 + 140 none 23.49 596 67.86 2e-60 lysine--tRNA ligase-like
blastp_kegg lcl|crb:CARUB_v10013215mg 46 183 + 138 none 22.04 626 70.29 2e-60 hypothetical protein
blastp_pdb 3bju_D 64 183 + 120 Gaps:1 22.84 521 44.54 4e-31 mol:protein length:521 Lysyl-tRNA synthetase
blastp_pdb 3bju_C 64 183 + 120 Gaps:1 22.84 521 44.54 4e-31 mol:protein length:521 Lysyl-tRNA synthetase
blastp_pdb 3bju_B 64 183 + 120 Gaps:1 22.84 521 44.54 4e-31 mol:protein length:521 Lysyl-tRNA synthetase
blastp_pdb 3bju_A 64 183 + 120 Gaps:1 22.84 521 44.54 4e-31 mol:protein length:521 Lysyl-tRNA synthetase
blastp_uniprot_sprot sp|Q9ZPI1|SYK_ARATH 44 183 + 140 none 22.36 626 67.14 1e-57 Lysine--tRNA ligase OS Arabidopsis thaliana GN At3g11710 PE 2 SV 1
blastp_uniprot_sprot sp|Q6F2U9|SYK_ORYSJ 55 183 + 129 none 21.43 602 61.24 4e-49 Lysine--tRNA ligase OS Oryza sativa subsp. japonica GN Os03g0586800 PE 2 SV 1
blastp_uniprot_sprot sp|Q43776|SYK_SOLLC 44 183 + 140 none 23.81 588 50.71 1e-45 Lysine--tRNA ligase OS Solanum lycopersicum GN LYSRS PE 2 SV 1
blastp_uniprot_sprot sp|Q99MN1|SYK_MOUSE 42 183 + 142 Gaps:1 23.70 595 41.13 4e-33 Lysine--tRNA ligase OS Mus musculus GN Kars PE 1 SV 1
blastp_uniprot_sprot sp|P37879|SYK_CRIGR 60 183 + 124 Gaps:1 20.60 597 44.72 2e-32 Lysine--tRNA ligase OS Cricetulus griseus GN KARS PE 1 SV 1
blastp_uniprot_sprot sp|Q9UUE6|SYKC_SCHPO 53 183 + 131 Gaps:3 22.00 591 41.54 5e-31 Lysine--tRNA ligase cytoplasmic OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN krs1 PE 3 SV 1
blastp_uniprot_sprot sp|Q15046|SYK_HUMAN 60 183 + 124 Gaps:1 20.60 597 43.90 8e-31 Lysine--tRNA ligase OS Homo sapiens GN KARS PE 1 SV 3
blastp_uniprot_sprot sp|Q22099|SYK_CAEEL 65 180 + 116 Gaps:2 19.93 572 46.49 4e-26 Lysine--tRNA ligase OS Caenorhabditis elegans GN krs-1 PE 3 SV 1
blastp_uniprot_sprot sp|P15180|SYKC_YEAST 63 183 + 121 Gaps:2 20.47 591 43.80 1e-25 Lysine--tRNA ligase cytoplasmic OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN KRS1 PE 1 SV 2
blastp_uniprot_sprot sp|Q9X231|SYK_THEMA 68 182 + 115 Gaps:3 22.31 502 36.61 3e-13 Lysine--tRNA ligase OS Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) GN lysS PE 3 SV 1
rpsblast_cdd gnl|CDD|178118 43 183 + 141 Gaps:1 25.32 553 59.29 4e-56 PLN02502 PLN02502 lysyl-tRNA synthetase.
rpsblast_cdd gnl|CDD|173607 44 183 + 140 Gaps:2 23.59 585 44.20 1e-33 PTZ00417 PTZ00417 lysine-tRNA ligase Provisional.
rpsblast_cdd gnl|CDD|188056 65 182 + 118 Gaps:4 23.39 496 34.48 3e-23 TIGR00499 lysS_bact lysyl-tRNA synthetase eukaryotic and non-spirochete bacterial. This model represents the lysyl-tRNA synthetases that are class II amino-acyl tRNA synthetases. It includes all eukaryotic and most bacterial examples of the enzyme but not archaeal or spirochete forms.
rpsblast_cdd gnl|CDD|179044 64 182 + 119 Gaps:5 23.63 491 32.76 1e-21 PRK00484 lysS lysyl-tRNA synthetase Reviewed.
rpsblast_cdd gnl|CDD|31383 60 183 + 124 Gaps:4 24.30 502 32.79 2e-21 COG1190 LysU Lysyl-tRNA synthetase (class II) [Translation ribosomal structure and biogenesis].
rpsblast_cdd gnl|CDD|58592 118 183 + 66 Gaps:3 58.33 108 52.38 3e-17 cd04322 LysRS_N LysRS_N: N-terminal anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. aaRSs catalyze the specific attachment of amino acids (AAs) to their cognate tRNAs during protein biosynthesis. This 2-step reaction involves i) the activation of the AA by ATP in the presence of magnesium ions followed by ii) the transfer of the activated AA to the terminal ribose of tRNA. In the case of the class2b aaRSs the activated AA is attached to the 3'OH of the terminal ribose. Included in this group are E. coli LysS and LysU. These two isoforms of LysRS are encoded by distinct genes which are differently regulated. Eukaryotes contain 2 sets of aaRSs both of which encoded by the nuclear genome. One set concerns with cytoplasmic protein synthesis whereas the other exclusively with mitochondrial protein synthesis. Saccharomyces cerevisiae cytoplasmic and mitochondrial LysRSs have been shown to participate in the mitochondrial import of the only nuclear-encoded tRNA of S. cerevisiae (tRNAlysCUU). The gene for human LysRS encodes both the cytoplasmic and the mitochondrial isoforms of LysRS. In addition to their housekeeping role human lysRS may function as a signaling molecule that activates immune cells and tomato LysRS may participate in a root-specific process possibly connected to conditions of oxidative-stress conditions or heavy metal uptake. It is known that human tRNAlys and LysRS are specifically packaged into HIV-1 suggesting a role for LysRS in tRNA packaging..

5 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Gene3D 67 182 116 G3DSA:2.40.50.140 none none IPR012340
SUPERFAMILY 64 182 119 SSF50249 none none IPR012340
PANTHER 5 183 179 PTHR22594 "Reactome:REACT_71";signature_desc=ASPARTYL/LYSYL-TRNA SYNTHETASE none IPR018150
PANTHER 5 183 179 PTHR22594:SF4 none none none
Pfam 119 182 64 PF01336 none OB-fold nucleic acid binding domain IPR004365

0 Localization

14 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2015_nEpis_3P Qrob_Chr12 12 s_1AOES6_1466 s_1B0DDG_1094 28,97 28,55 30,1 lod 3.6 8.4
Bourran2_2014_nPriLBD*_3P Qrob_Chr11 11 v_12066_307 s_1B15GJ_447 3,37 0,57 16,17 lod 3,4299 6,9
Bourran2_2014_nP_A4 Qrob_Chr11 11 s_1B58GB_1413 s_1A5BYY_1671 11,15 0 42,38 lod 1,8913 4,5
Bourran2_2002_QTL16_peak_Bud_burst_A4 Qrob_Chr11 11 s_A9OIA_166 s_1C6WBF_114 21,23 2,83 42,83 lod 5,1 7,2
Bourran2_2015_nSeqBC_3P Qrob_Chr11 11 s_1DG9PM_867 s_1BZ083_1312 26,06 25,47 27,72 lod 3.6 7.1
Bourran2_2014_nP_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 7,9 0,09 30,09 lod 2,3636 5
Bourran2_2014_nPriBD_3P Qrob_Chr11 11 v_11486_194 s_1AT3E_2335 5,54 0,4 20,6 lod 2,6345 5,9
Bourran1_2003_QTL6_peak_Bud_burst_A4 Qrob_Chr11 11 v_12066_307 s_1A9FKZ_348 3,59 0 20,89 lod 3,4 9,4
PM_1999_QTL17_peak_Bud_burst_3P Qrob_Chr11 11 s_1A9FKZ_348 v_11486_883 4,8 0 24,8 lod 3,5 6,2
Bourran_2000_2002_QTL1_Delta.F Qrob_Chr11 11 v_AC14YL05_1355 s_2F1WOG_696 10.96 3,25 16,39 lod 25.0121 0.2
Bourran_2000_2002_QTL5_Delta.F Qrob_Chr11 11 s_1BD29X_620 s_2F1WOG_696 2.94 1,08 16,39 lod 5.936 0.05
Bourran2_2014_vEpiBC*_3P Qrob_Chr11 11 s_1A5GRX_415 v_4456_500 9,37 0 19,27 lod 3,513 9,3
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL1_d13Cf Qrob_Chr11 11 s_1A9FKZ_348 v_7268_36 13.33 3,98 19,87 lod 29.1377 0.18
NancyGreenhouseCO2_2001_ambient_elevated_leaf_cellulose_QTL5_d13Cf Qrob_Chr11 11 s_1BD29X_620 s_1A5BYY_1671 2.26 1,08 11,24 lod 5.8451 0.037

0 Targeting