Protein : Qrob_P0045460.2 Q. robur
Protein Identifier  ? Qrob_P0045460.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=4) PTHR11706:SF8 - NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN (NRAMP) (MANGANESE TRANSPORTER) Gene Prediction Quality  validated
Protein length 

Sequence

Length: 340  
Kegg Orthology  K12347
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0005215 transporter activity Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.

25 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pper:PRUPE_ppa003966mg 1 339 + 339 none 63.13 537 83.48 0.0 hypothetical protein
blastp_kegg lcl|pmum:103320391 1 338 + 338 none 62.94 537 82.25 0.0 metal transporter Nramp2-like
blastp_kegg lcl|pxb:103945303 1 339 + 339 none 63.36 535 81.42 0.0 metal transporter Nramp2-like
blastp_kegg lcl|tcc:TCM_034751 2 339 + 338 Gaps:1 62.66 541 82.30 0.0 NRAMP metal ion transporter 2 isoform 1
blastp_kegg lcl|mdm:103415425 1 339 + 339 none 63.13 537 79.94 0.0 metal transporter Nramp2-like
blastp_kegg lcl|cam:101506428 2 339 + 338 none 63.77 530 79.59 0.0 metal transporter Nramp2-like
blastp_kegg lcl|pxb:103950751 1 339 + 339 none 63.13 537 79.94 0.0 metal transporter Nramp2-like
blastp_kegg lcl|mdm:103455925 2 339 + 338 none 62.94 537 80.18 0.0 metal transporter Nramp2-like
blastp_kegg lcl|cic:CICLE_v10000826mg 1 339 + 339 Gaps:1 63.91 532 80.59 0.0 hypothetical protein
blastp_kegg lcl|mdm:103441073 1 339 + 339 none 63.36 535 80.24 0.0 metal transporter Nramp2-like
blastp_uniprot_sprot sp|Q9C6B2|NRAM2_ARATH 2 319 + 318 none 60.00 530 82.08 0.0 Metal transporter Nramp2 OS Arabidopsis thaliana GN NRAMP2 PE 2 SV 1
blastp_uniprot_sprot sp|Q2QN30|NRAM6_ORYSJ 1 335 + 335 Gaps:1 61.74 541 72.46 3e-173 Metal transporter Nramp6 OS Oryza sativa subsp. japonica GN NRAMP6 PE 2 SV 1
blastp_uniprot_sprot sp|Q9SNV9|NRAM3_ARATH 1 322 + 322 none 63.26 509 73.91 2e-171 Metal transporter Nramp3 OS Arabidopsis thaliana GN NRAMP3 PE 2 SV 2
blastp_uniprot_sprot sp|Q9SN36|NRAM5_ARATH 2 316 + 315 none 59.43 530 71.75 1e-165 Metal transporter Nramp5 OS Arabidopsis thaliana GN NRAMP5 PE 2 SV 1
blastp_uniprot_sprot sp|Q9FN18|NRAM4_ARATH 1 322 + 322 none 62.89 512 68.01 1e-161 Metal transporter Nramp4 OS Arabidopsis thaliana GN NRAMP4 PE 2 SV 1
blastp_uniprot_sprot sp|Q10Q65|NRAM2_ORYSJ 2 332 + 331 none 63.17 524 67.98 2e-159 Metal transporter Nramp2 OS Oryza sativa subsp. japonica GN NRAMP2 PE 2 SV 1
blastp_uniprot_sprot sp|Q869V1|NRAM1_DICDI 2 257 + 256 Gaps:8 46.53 533 52.42 3e-80 Metal transporter nramp1 homolog OS Dictyostelium discoideum GN nramp1 PE 2 SV 1
blastp_uniprot_sprot sp|P49281|NRAM2_HUMAN 2 278 + 277 Gaps:30 51.58 568 47.10 1e-75 Natural resistance-associated macrophage protein 2 OS Homo sapiens GN SLC11A2 PE 1 SV 2
blastp_uniprot_sprot sp|P49282|NRAM2_MOUSE 2 278 + 277 Gaps:30 51.58 568 45.73 1e-72 Natural resistance-associated macrophage protein 2 OS Mus musculus GN Slc11a2 PE 1 SV 2
blastp_uniprot_sprot sp|O54902|NRAM2_RAT 2 278 + 277 Gaps:30 51.58 568 45.39 3e-72 Natural resistance-associated macrophage protein 2 OS Rattus norvegicus GN Slc11a2 PE 1 SV 1
rpsblast_cdd gnl|CDD|162246 2 256 + 255 Gaps:25 68.72 390 39.93 4e-56 TIGR01197 nramp NRAMP (natural resistance-associated macrophage protein) metal ion transporters. This model describes the Nramp metal ion transporter family. Historically in mammals these proteins have been functionally characterized as proteins involved in the host pathogen resistance hence the name - NRAMP. At least two isoforms Nramp1 and Nramp2 have been identified. However the exact mechanism of pathogen resistance was unclear until it was demonstrated by expression cloning and electrophysiological techniques that this protein was a metal ion transporter. It was also independently demonstrated that a microcytic anemia (mk) locus in mouse encodes a metal ion transporter (DCT1 or Nramp2). The transporter has a broad range of substrate specificity that include Fe+2 Zn+2 Mn+2 Co+2 Cd+2 Cu+2 Ni+2 and Pb+2. The uptake of these metal ions is coupled to proton symport. Metal ions are essential cofactors in a number of biological process including oxidative phosphorylation gene regulation and metal ion homeostasis. Nramp1 could confer resistance to infection in one of the two ways. (1) The uptake of Fe+2 can produce toxic hydroxyl radicals via Fenton reaction killing the pathogens in phagosomes or (2) Deplete the metal ion pools in the phagosome and deprive the pathogens of metal ions which is critical for its survival.
rpsblast_cdd gnl|CDD|201864 1 263 + 263 Gaps:8 72.80 364 35.47 9e-56 pfam01566 Nramp Natural resistance-associated macrophage protein. The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1 Nramp2 and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+ Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.
rpsblast_cdd gnl|CDD|179090 2 288 + 287 Gaps:13 64.69 439 34.15 1e-53 PRK00701 PRK00701 manganese transport protein MntH Reviewed.
rpsblast_cdd gnl|CDD|32098 2 290 + 289 Gaps:12 67.07 416 34.41 1e-31 COG1914 MntH Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism].
rpsblast_kog gnl|CDD|36505 1 319 + 319 Gaps:23 66.00 503 53.31 3e-97 KOG1291 KOG1291 KOG1291 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism].

25 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Phobius 290 294 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 218 236 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PRINTS 14 35 22 PR00447 "Reactome:REACT_15518" Natural resistance-associated macrophage protein signature IPR001046
PRINTS 232 251 20 PR00447 "Reactome:REACT_15518" Natural resistance-associated macrophage protein signature IPR001046
PRINTS 198 215 18 PR00447 "Reactome:REACT_15518" Natural resistance-associated macrophage protein signature IPR001046
PRINTS 63 86 24 PR00447 "Reactome:REACT_15518" Natural resistance-associated macrophage protein signature IPR001046
PRINTS 170 189 20 PR00447 "Reactome:REACT_15518" Natural resistance-associated macrophage protein signature IPR001046
Phobius 151 169 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 109 130 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 1 319 319 PTHR11706 "Reactome:REACT_15518";signature_desc=MANGANESE TRANSPORTER none IPR001046
Phobius 268 289 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 1 319 319 PTHR11706:SF8 none none none
Phobius 194 199 6 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 257 267 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 170 174 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 237 256 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 318 339 22 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 38 108 71 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 295 317 23 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 20 37 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 1 19 19 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Pfam 1 262 262 PF01566 "Reactome:REACT_15518" Natural resistance-associated macrophage protein IPR001046
Phobius 175 193 19 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 131 150 20 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 200 217 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none

8 Localization

Analysis Start End Length
TMHMM 263 285 22
TMHMM 151 170 19
TMHMM 200 217 17
TMHMM 295 317 22
TMHMM 20 37 17
TMHMM 109 131 22
TMHMM 174 193 19
TMHMM 232 251 19

0 Qtllist

1 Targeting

Analysis Start End Length Location Reliability Signal Peptide Cut Off Mitochondrion Cut Off Network Signal Peptide Length
TargetP 1 33   Secretory pathway 4 0.817 0.021 NON-PLANT 33