Protein : Qrob_P0045450.2 Q. robur
Protein Identifier  ? Qrob_P0045450.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=4) PTHR11706:SF8 - NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN (NRAMP) (MANGANESE TRANSPORTER) Gene Prediction Quality  validated
Protein length 

Sequence

Length: 198  
Kegg Orthology  K12347
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0005215 transporter activity Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.

25 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pvu:PHAVU_009G069700g 7 180 + 174 Gaps:11 34.66 528 74.86 6e-83 hypothetical protein
blastp_kegg lcl|fve:101292870 1 180 + 180 Gaps:16 36.29 529 70.31 9e-82 metal transporter Nramp2-like
blastp_kegg lcl|cic:CICLE_v10000826mg 4 180 + 177 Gaps:17 35.71 532 71.58 1e-81 hypothetical protein
blastp_kegg lcl|cit:102613637 4 180 + 177 Gaps:17 35.71 532 71.05 1e-81 metal transporter Nramp2-like
blastp_kegg lcl|mtr:MTR_061s1019 7 180 + 174 Gaps:9 34.66 528 73.22 2e-81 Natural resistance-associated macrophage protein
blastp_kegg lcl|mtr:MTR_133s1020 7 180 + 174 Gaps:9 34.66 528 73.22 2e-81 Natural resistance-associated macrophage protein
blastp_kegg lcl|pmum:103320391 1 180 + 180 Gaps:20 37.24 537 69.00 3e-81 metal transporter Nramp2-like
blastp_kegg lcl|pper:PRUPE_ppa003966mg 1 180 + 180 Gaps:20 37.24 537 68.50 4e-80 hypothetical protein
blastp_kegg lcl|rcu:RCOM_1588250 10 180 + 171 Gaps:13 39.83 462 70.11 8e-80 natural resistance-associated macrophage protein putative
blastp_kegg lcl|brp:103849582 5 180 + 176 Gaps:11 35.48 527 68.45 2e-79 metal transporter Nramp2
blastp_uniprot_sprot sp|Q9C6B2|NRAM2_ARATH 23 180 + 158 Gaps:2 30.19 530 78.75 1e-79 Metal transporter Nramp2 OS Arabidopsis thaliana GN NRAMP2 PE 2 SV 1
blastp_uniprot_sprot sp|Q9SNV9|NRAM3_ARATH 34 180 + 147 Gaps:5 29.86 509 76.97 5e-73 Metal transporter Nramp3 OS Arabidopsis thaliana GN NRAMP3 PE 2 SV 2
blastp_uniprot_sprot sp|Q9FN18|NRAM4_ARATH 16 180 + 165 Gaps:8 33.79 512 69.94 3e-71 Metal transporter Nramp4 OS Arabidopsis thaliana GN NRAMP4 PE 2 SV 1
blastp_uniprot_sprot sp|Q9SN36|NRAM5_ARATH 10 180 + 171 Gaps:8 30.75 530 73.01 8e-66 Metal transporter Nramp5 OS Arabidopsis thaliana GN NRAMP5 PE 2 SV 1
blastp_uniprot_sprot sp|Q10Q65|NRAM2_ORYSJ 51 180 + 130 none 24.81 524 78.46 2e-65 Metal transporter Nramp2 OS Oryza sativa subsp. japonica GN NRAMP2 PE 2 SV 1
blastp_uniprot_sprot sp|Q2QN30|NRAM6_ORYSJ 22 194 + 173 Gaps:11 29.94 541 70.37 2e-64 Metal transporter Nramp6 OS Oryza sativa subsp. japonica GN NRAMP6 PE 2 SV 1
blastp_uniprot_sprot sp|Q869V1|NRAM1_DICDI 54 180 + 127 none 23.83 533 66.93 1e-55 Metal transporter nramp1 homolog OS Dictyostelium discoideum GN nramp1 PE 2 SV 1
blastp_uniprot_sprot sp|P49283|MVL_DROME 16 180 + 165 Gaps:6 26.68 596 55.35 5e-52 Protein Malvolio OS Drosophila melanogaster GN Mvl PE 2 SV 2
blastp_uniprot_sprot sp|Q9XT74|NRAM1_CANFA 5 180 + 176 Gaps:1 32.36 547 50.28 2e-49 Natural resistance-associated macrophage protein 1 OS Canis familiaris GN SLC11A1 PE 2 SV 2
blastp_uniprot_sprot sp|P51027|NRAM1_CHICK 49 180 + 132 none 23.78 555 60.61 2e-49 Natural resistance-associated macrophage protein 1 OS Gallus gallus GN SLC11A1 PE 2 SV 1
rpsblast_cdd gnl|CDD|162246 56 180 + 125 Gaps:2 31.54 390 60.98 2e-49 TIGR01197 nramp NRAMP (natural resistance-associated macrophage protein) metal ion transporters. This model describes the Nramp metal ion transporter family. Historically in mammals these proteins have been functionally characterized as proteins involved in the host pathogen resistance hence the name - NRAMP. At least two isoforms Nramp1 and Nramp2 have been identified. However the exact mechanism of pathogen resistance was unclear until it was demonstrated by expression cloning and electrophysiological techniques that this protein was a metal ion transporter. It was also independently demonstrated that a microcytic anemia (mk) locus in mouse encodes a metal ion transporter (DCT1 or Nramp2). The transporter has a broad range of substrate specificity that include Fe+2 Zn+2 Mn+2 Co+2 Cd+2 Cu+2 Ni+2 and Pb+2. The uptake of these metal ions is coupled to proton symport. Metal ions are essential cofactors in a number of biological process including oxidative phosphorylation gene regulation and metal ion homeostasis. Nramp1 could confer resistance to infection in one of the two ways. (1) The uptake of Fe+2 can produce toxic hydroxyl radicals via Fenton reaction killing the pathogens in phagosomes or (2) Deplete the metal ion pools in the phagosome and deprive the pathogens of metal ions which is critical for its survival.
rpsblast_cdd gnl|CDD|179090 54 180 + 127 Gaps:2 28.47 439 47.20 3e-40 PRK00701 PRK00701 manganese transport protein MntH Reviewed.
rpsblast_cdd gnl|CDD|201864 81 180 + 100 Gaps:2 26.92 364 50.00 2e-31 pfam01566 Nramp Natural resistance-associated macrophage protein. The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1 Nramp2 and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+ Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.
rpsblast_cdd gnl|CDD|32098 54 181 + 128 Gaps:2 30.29 416 47.62 2e-29 COG1914 MntH Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism].
rpsblast_kog gnl|CDD|36505 32 180 + 149 Gaps:2 29.22 503 65.31 2e-60 KOG1291 KOG1291 KOG1291 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism].

13 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Coils 14 35 22 Coil none none none
Phobius 87 109 23 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Pfam 80 180 101 PF01566 "Reactome:REACT_15518" Natural resistance-associated macrophage protein IPR001046
PRINTS 137 163 27 PR00447 "Reactome:REACT_15518" Natural resistance-associated macrophage protein signature IPR001046
PRINTS 167 186 20 PR00447 "Reactome:REACT_15518" Natural resistance-associated macrophage protein signature IPR001046
Phobius 1 57 57 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 110 128 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
PANTHER 10 180 171 PTHR11706 "Reactome:REACT_15518";signature_desc=MANGANESE TRANSPORTER none IPR001046
PANTHER 10 180 171 PTHR11706:SF8 none none none
Phobius 129 148 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 58 75 18 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 149 197 49 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 76 86 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none

3 Localization

Analysis Start End Length
TMHMM 87 109 22
TMHMM 129 146 17
TMHMM 153 175 22

0 Qtllist

0 Targeting