Protein : Qrob_P0026920.2 Q. robur
Protein Identifier  ? Qrob_P0026920.2 Organism . Name  Quercus robur
Score  100.0 Score Type  egn
Protein Description  (M=2) K17081 - prohibitin 2 Gene Prediction Quality  validated
Protein length 

Sequence

Length: 291  
Kegg Orthology  K17081
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Protein Sequence Displayer

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0 Synonyms

1 GO Terms

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

30 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|pop:POPTR_0007s01410g 1 290 + 290 none 100.00 290 85.86 0.0 POPTRDRAFT_832191 PROHIBITIN 2 family protein
blastp_kegg lcl|mtr:MTR_4g078200 1 290 + 290 none 98.98 293 85.52 0.0 Prohibitin 1-like protein
blastp_kegg lcl|sly:101267849 1 289 + 289 none 100.00 289 85.81 0.0 prohibitin-2 mitochondrial-like
blastp_kegg lcl|rcu:RCOM_1171660 1 290 + 290 none 100.00 290 84.48 0.0 prohibitin putative
blastp_kegg lcl|pvu:PHAVU_005G099600g 1 289 + 289 none 100.00 289 83.74 0.0 hypothetical protein
blastp_kegg lcl|cit:102628560 1 285 + 285 none 98.96 288 86.32 1e-180 prohibitin-1 mitochondrial-like
blastp_kegg lcl|tcc:TCM_008242 1 290 + 290 none 100.00 290 82.41 5e-179 Prohibitin 2
blastp_kegg lcl|csv:101204771 1 290 + 290 none 100.00 290 84.83 9e-177 prohibitin-2-like
blastp_kegg lcl|cam:101510076 1 290 + 290 Gaps:1 100.00 289 87.54 9e-177 prohibitin-1 mitochondrial-like
blastp_kegg lcl|atr:s00058p00112040 1 290 + 290 Gaps:1 99.66 292 84.88 1e-175 AMTR_s00058p00112040 hypothetical protein
blastp_uniprot_sprot sp|Q9ZNT7|PHB2_ARATH 1 286 + 286 Gaps:2 99.30 286 80.28 3e-164 Prohibitin-2 mitochondrial OS Arabidopsis thaliana GN PHB2 PE 1 SV 1
blastp_uniprot_sprot sp|O49460|PHB1_ARATH 3 289 + 287 none 99.65 288 83.97 2e-162 Prohibitin-1 mitochondrial OS Arabidopsis thaliana GN PHB1 PE 1 SV 1
blastp_uniprot_sprot sp|Q9SIL6|PHB6_ARATH 1 290 + 290 Gaps:4 100.00 286 80.42 5e-161 Prohibitin-6 mitochondrial OS Arabidopsis thaliana GN PHB6 PE 1 SV 1
blastp_uniprot_sprot sp|Q9FFH5|PHB7_ARATH 3 280 + 278 none 100.00 278 73.38 3e-147 Prohibitin-7 mitochondrial OS Arabidopsis thaliana GN PHB7 PE 1 SV 1
blastp_uniprot_sprot sp|Q54Q31|PHB2_DICDI 1 290 + 290 Gaps:4 97.61 293 59.09 5e-112 Prohibitin-2 OS Dictyostelium discoideum GN phbB PE 3 SV 1
blastp_uniprot_sprot sp|Q5XIH7|PHB2_RAT 7 281 + 275 Gaps:3 91.64 299 54.74 4e-106 Prohibitin-2 OS Rattus norvegicus GN Phb2 PE 1 SV 1
blastp_uniprot_sprot sp|O35129|PHB2_MOUSE 7 281 + 275 Gaps:3 91.64 299 54.74 7e-106 Prohibitin-2 OS Mus musculus GN Phb2 PE 1 SV 1
blastp_uniprot_sprot sp|Q99623|PHB2_HUMAN 7 281 + 275 Gaps:3 91.64 299 54.74 7e-106 Prohibitin-2 OS Homo sapiens GN PHB2 PE 1 SV 2
blastp_uniprot_sprot sp|A9UMS3|PHB2_XENTR 7 281 + 275 Gaps:3 91.03 301 55.11 1e-105 Prohibitin-2 OS Xenopus tropicalis GN phb2 PE 2 SV 1
blastp_uniprot_sprot sp|Q2HJ97|PHB2_BOVIN 7 281 + 275 Gaps:3 91.64 299 54.74 3e-105 Prohibitin-2 OS Bos taurus GN PHB2 PE 2 SV 1
rpsblast_cdd gnl|CDD|48213 37 232 + 196 none 100.00 196 68.37 3e-83 cd03401 Band_7_prohibitin Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. These microdomains in addition to being stable scaffolds may also be also dynamic units with their own regulatory functions. Prohibitin is a mitochondrial inner-membrane protein which may act as a chaperone for the stabilization of mitochondrial proteins. Human prohibitin forms a heter-oligomeric complex with Bap-37 (prohibitin 2 a band 7 domain carrying homologue). This complex may protect non-assembled membrane proteins against proteolysis by the m-AAA protease. Prohibitin and Bap-37 yeast homologues have been implicated in yeast longevity and in the maintenance of mitochondrial morphology..
rpsblast_cdd gnl|CDD|197600 37 198 + 162 Gaps:6 100.00 160 31.25 7e-28 smart00244 PHB prohibitin homologues. prohibitin homologues.
rpsblast_cdd gnl|CDD|30678 23 289 + 267 Gaps:18 90.38 291 26.24 3e-19 COG0330 HflC Membrane protease subunits stomatin/prohibitin homologs [Posttranslational modification protein turnover chaperones].
rpsblast_cdd gnl|CDD|201624 39 215 + 177 Gaps:7 99.44 177 27.84 5e-19 pfam01145 Band_7 SPFH domain / Band 7 family. This family has been called SPFH Band 7 or PHB domain. Recent phylogenetic analysis has shown this domain to be a slipin or Stomatin-like integral membrane domain conserved from protozoa to mammals.
rpsblast_cdd gnl|CDD|48217 38 257 + 220 Gaps:31 99.59 242 22.82 4e-13 cd03405 Band_7_HflC Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated prokaryote plasma membranes lack cholesterol and are unlikely to have lipid raft domains. Individual proteins of this band 7 domain family may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Escherichia coli HflC is an integral membrane protein which may localize to the plasma membrane. HflC associates with another band 7 family member (HflK) to form an HflKC complex. HflKC interacts with FtsH in a large complex termed the FtsH holo-enzyme. FtsH is an AAA ATP-dependent protease which exerts progressive proteolysis against membrane-embedded and soluble substrate proteins. HflKC can modulate the activity of FtsH. HflKC plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection..
rpsblast_cdd gnl|CDD|48210 76 198 + 123 Gaps:2 100.00 121 22.31 9e-13 cd02106 Band_7 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin prohibitin flotillin HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this band 7 domain family may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction vesicle trafficking cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and in cancer invasion and metastasis. Mutations in the podicin gene give rise to autosomal recessive steroid resistant nephritic syndrome.
rpsblast_cdd gnl|CDD|48215 41 258 + 218 Gaps:25 94.42 215 29.06 4e-09 cd03403 Band_7_stomatin_like Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Stomatin is widely expressed and highly expressed in red blood cells. It localizes predominantly to the plasma membrane and to intracellular vesicles of the endocytic pathway where it is present in higher order homo-oligomeric complexes (of between 9 and 12 monomers). Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and is implicated in trafficking of Glut1 glucose transporters. Prohibitin is a mitochondrial inner-membrane protein hypothesized to act as a chaperone for the stabilization of mitochondrial proteins. Podicin localizes to the plasma membrane of podocyte foot processes and is found in higher order oligomers. Podocin plays a role in regulating glomerular permeability. Mutations in the podicin gene give rise to autosomal recessive steroid resistant nephritic syndrome. This group also contains proteins similar to three Caenorhabditis elegans proteins: UNC-1 UNC-24 and MEC-2. Mutations in the unc-1 and unc-24 genes result in abnormal motion and altered patterns of sensitivity to volatile anesthetics. MEC-2 and UNC-24 proteins interact with MEC-4 which is part of the degenerin channel complex required for response to gentle body touch..
rpsblast_cdd gnl|CDD|48212 99 198 + 100 Gaps:1 81.45 124 21.78 6e-07 cd03400 Band_7_1 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin prohibitin flotillin HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this band 7 domain family may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction vesicle trafficking cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and in cancer invasion and metastasis. Mutations in the podicin gene give rise to autosomal recessive steroid resistant nephritic syndrome..
rpsblast_kog gnl|CDD|38300 1 290 + 290 none 100.00 290 73.10 1e-132 KOG3090 KOG3090 KOG3090 Prohibitin-like protein [Posttranslational modification protein turnover chaperones].
rpsblast_kog gnl|CDD|38293 18 270 + 253 Gaps:1 93.73 271 52.36 2e-81 KOG3083 KOG3083 KOG3083 Prohibitin [Posttranslational modification protein turnover chaperones].

11 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PRINTS 216 232 17 PR00679 none Prohibitin signature IPR000163
PRINTS 193 216 24 PR00679 none Prohibitin signature IPR000163
PRINTS 81 97 17 PR00679 none Prohibitin signature IPR000163
PRINTS 99 118 20 PR00679 none Prohibitin signature IPR000163
PRINTS 122 140 19 PR00679 none Prohibitin signature IPR000163
PRINTS 145 161 17 PR00679 none Prohibitin signature IPR000163
PRINTS 168 187 20 PR00679 none Prohibitin signature IPR000163
Pfam 40 216 177 PF01145 none SPFH domain / Band 7 family IPR001107
SMART 37 198 162 SM00244 none prohibitin homologues IPR001107
PANTHER 2 288 287 PTHR23222 none none IPR000163
SUPERFAMILY 69 204 136 SSF117892 none none none

0 Localization

8 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran_2000_2002_QTL7_Delta.F Qrob_Chr09 9 v_5944_442 s_1BA1PC_866 23.51 10,96 35,74 lod 4.1466 0.041
Bourran2_2003_QTL11_peak_Bud_burst_3P Qrob_Chr09 9 s_1CGP2H_273 v_15801_330 27,16 4,16 48,16 lod 2,3 5,1
Bourran2_2004_QTL12_peak_Bud_burst_3P Qrob_Chr09 9 s_1BDO6G_250 s_1A83AM_496 34,31 9,31 44,31 lod 3,6 7,6
Bourran2_2004_QTL14_peak_Bud_burst_A4 Qrob_Chr09 9 s_1BY6BQ_440 s_1AOIKO_756 16,83 10,33 22,33 lod 3,8 9
Bourran2_2015_nEpis_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 34,94 34,88 37,45 lod 3.1 7
Bourran2_2015_nSecLBD_A4 Qrob_Chr09 9 v_15847_485 v_8329_369 35,81 34,88 37,45 lod 4.4 10.4
PM_1999_QTL15_peak_Bud_burst_3P Qrob_Chr09 9 s_1CGP2H_273 v_15801_330 27,16 9,16 47,16 lod 3,6 6,5
Bourran1_2003_QTL5_peak_Bud_burst_3P Qrob_Chr09 9 s_1ATM17_504 s_1AYZFM_899 29,81 19,81 41,81 lod 3,3 8,9

0 Targeting