Protein : Qrob_P0012990.2 Q. robur
Protein Identifier  ? Qrob_P0012990.2 Organism . Name  Quercus robur
Score  99.0 Score Type  egn
Protein Description  (M=13) PTHR11706:SF33 - NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1 (PTHR11706:SF33) Gene Prediction Quality  validated
Protein length 

Sequence

Length: 372  
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0005215 transporter activity Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.

25 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|cic:CICLE_v10000736mg 6 371 + 366 Gaps:2 65.12 559 71.15 0.0 hypothetical protein
blastp_kegg lcl|cit:102625328 6 371 + 366 Gaps:2 65.12 559 71.15 0.0 metal transporter Nramp5-like
blastp_kegg lcl|vvi:100266052 6 371 + 366 Gaps:1 67.34 542 69.32 0.0 metal transporter Nramp5-like
blastp_kegg lcl|pop:POPTR_0002s08100g 6 371 + 366 Gaps:1 66.85 546 69.59 0.0 hypothetical protein
blastp_kegg lcl|tcc:TCM_035174 6 371 + 366 Gaps:1 65.53 557 68.77 0.0 Nramp transporter
blastp_kegg lcl|pop:POPTR_0002s08090g 6 371 + 366 Gaps:2 66.30 552 69.40 0.0 hypothetical protein
blastp_kegg lcl|mdm:103424089 6 371 + 366 Gaps:5 81.67 442 68.42 0.0 metal transporter Nramp5-like
blastp_kegg lcl|tcc:TCM_035168 6 371 + 366 Gaps:1 65.06 561 68.22 0.0 Nramp transporter isoform 1
blastp_kegg lcl|pmum:103319788 6 371 + 366 Gaps:5 66.12 546 68.42 0.0 metal transporter Nramp5-like
blastp_kegg lcl|pxb:103950022 6 371 + 366 Gaps:5 65.76 549 69.25 0.0 metal transporter Nramp5-like
blastp_uniprot_sprot sp|Q8H4H5|NRAM5_ORYSJ 6 371 + 366 Gaps:3 67.47 538 65.01 1e-171 Metal transporter Nramp5 OS Oryza sativa subsp. japonica GN NRAMP5 PE 2 SV 1
blastp_uniprot_sprot sp|Q0D7E4|NRAM1_ORYSJ 6 323 + 318 none 61.39 518 64.15 2e-151 Metal transporter Nramp1 OS Oryza sativa subsp. japonica GN NRAMP1 PE 2 SV 1
blastp_uniprot_sprot sp|Q6ZG85|NRAT1_ORYSJ 7 366 + 360 Gaps:7 65.87 545 56.55 5e-142 Metal transporter NRAT1 OS Oryza sativa subsp. japonica GN NRAT1 PE 2 SV 1
blastp_uniprot_sprot sp|Q653V6|NRAM3_ORYSJ 6 371 + 366 Gaps:13 65.64 550 55.12 6e-133 Metal transporter Nramp3 OS Oryza sativa subsp. japonica GN NRAMP3 PE 2 SV 1
blastp_uniprot_sprot sp|Q9SAH8|NRAM1_ARATH 6 326 + 321 none 60.34 532 57.32 3e-130 Metal transporter Nramp1 OS Arabidopsis thaliana GN NRAMP1 PE 1 SV 1
blastp_uniprot_sprot sp|Q9S9N8|NRAM6_ARATH 6 344 + 339 none 64.33 527 53.10 8e-130 Metal transporter Nramp6 OS Arabidopsis thaliana GN NRAMP6 PE 2 SV 2
blastp_uniprot_sprot sp|Q5QN13|NRAM4_ORYSJ 7 367 + 361 Gaps:19 62.18 550 47.37 6e-104 Metal transporter Nramp4 OS Oryza sativa subsp. japonica GN NRAMP4 PE 2 SV 1
blastp_uniprot_sprot sp|Q9SN36|NRAM5_ARATH 6 317 + 312 Gaps:22 56.98 530 38.74 9e-50 Metal transporter Nramp5 OS Arabidopsis thaliana GN NRAMP5 PE 2 SV 1
blastp_uniprot_sprot sp|Q2QN30|NRAM6_ORYSJ 6 320 + 315 Gaps:21 56.19 541 38.49 1e-48 Metal transporter Nramp6 OS Oryza sativa subsp. japonica GN NRAMP6 PE 2 SV 1
blastp_uniprot_sprot sp|Q8ZSB0|MNTH_NOSS1 7 288 + 282 Gaps:12 62.90 442 36.33 4e-48 Divalent metal cation transporter MntH OS Nostoc sp. (strain PCC 7120 / UTEX 2576) GN mntH PE 3 SV 1
rpsblast_cdd gnl|CDD|179090 7 285 + 279 Gaps:11 62.41 439 40.15 1e-61 PRK00701 PRK00701 manganese transport protein MntH Reviewed.
rpsblast_cdd gnl|CDD|201864 1 256 + 256 Gaps:14 70.33 364 37.89 1e-54 pfam01566 Nramp Natural resistance-associated macrophage protein. The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1 Nramp2 and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+ Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.
rpsblast_cdd gnl|CDD|162246 6 250 + 245 Gaps:11 65.64 390 39.06 4e-49 TIGR01197 nramp NRAMP (natural resistance-associated macrophage protein) metal ion transporters. This model describes the Nramp metal ion transporter family. Historically in mammals these proteins have been functionally characterized as proteins involved in the host pathogen resistance hence the name - NRAMP. At least two isoforms Nramp1 and Nramp2 have been identified. However the exact mechanism of pathogen resistance was unclear until it was demonstrated by expression cloning and electrophysiological techniques that this protein was a metal ion transporter. It was also independently demonstrated that a microcytic anemia (mk) locus in mouse encodes a metal ion transporter (DCT1 or Nramp2). The transporter has a broad range of substrate specificity that include Fe+2 Zn+2 Mn+2 Co+2 Cd+2 Cu+2 Ni+2 and Pb+2. The uptake of these metal ions is coupled to proton symport. Metal ions are essential cofactors in a number of biological process including oxidative phosphorylation gene regulation and metal ion homeostasis. Nramp1 could confer resistance to infection in one of the two ways. (1) The uptake of Fe+2 can produce toxic hydroxyl radicals via Fenton reaction killing the pathogens in phagosomes or (2) Deplete the metal ion pools in the phagosome and deprive the pathogens of metal ions which is critical for its survival.
rpsblast_cdd gnl|CDD|32098 1 286 + 286 Gaps:10 66.35 416 34.06 1e-36 COG1914 MntH Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism].
rpsblast_kog gnl|CDD|36505 6 321 + 316 Gaps:11 64.61 503 39.08 3e-70 KOG1291 KOG1291 KOG1291 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism].

26 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
Pfam 3 256 254 PF01566 "Reactome:REACT_15518" Natural resistance-associated macrophage protein IPR001046
Phobius 12 31 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 51 71 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 289 293 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 156 175 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 6 368 363 PTHR11706:SF33 none none none
PRINTS 226 245 20 PR00447 "Reactome:REACT_15518" Natural resistance-associated macrophage protein signature IPR001046
PRINTS 56 79 24 PR00447 "Reactome:REACT_15518" Natural resistance-associated macrophage protein signature IPR001046
PRINTS 194 211 18 PR00447 "Reactome:REACT_15518" Natural resistance-associated macrophage protein signature IPR001046
PRINTS 6 27 22 PR00447 "Reactome:REACT_15518" Natural resistance-associated macrophage protein signature IPR001046
PRINTS 166 185 20 PR00447 "Reactome:REACT_15518" Natural resistance-associated macrophage protein signature IPR001046
Phobius 318 371 54 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 32 50 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 176 195 20 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 221 245 25 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 1 11 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 246 256 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
PANTHER 6 368 363 PTHR11706 "Reactome:REACT_15518";signature_desc=MANGANESE TRANSPORTER none IPR001046
Phobius 294 317 24 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 196 215 20 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 257 288 32 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
ProSiteProfiles 1 23 23 PS51257 none Prokaryotic membrane lipoprotein lipid attachment site profile. none
Phobius 117 155 39 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 216 220 5 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 92 116 25 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 72 91 20 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none

8 Localization

Analysis Start End Length
TMHMM 294 316 22
TMHMM 51 73 22
TMHMM 223 245 22
TMHMM 257 279 22
TMHMM 191 213 22
TMHMM 157 179 22
TMHMM 12 31 19
TMHMM 94 116 22

2 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2014_rEpiBC_3P Qrob_Chr05 5 s_2GDU0O_517 s_1BT8O3_239 25,81 0 55,45 lod 2,2101 5,5

1 Targeting

Analysis Start End Length Location Reliability Signal Peptide Cut Off Mitochondrion Cut Off Network Signal Peptide Length
TargetP 1 21   Secretory pathway 1 0.980 0.013 NON-PLANT 21