Protein : Qrob_P0012970.2 Q. robur
Protein Identifier  ? Qrob_P0012970.2 Organism . Name  Quercus robur
Score  0.0 Score Type  egn
Protein Description  (M=13) PTHR11706:SF33 - NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1 (PTHR11706:SF33) Gene Prediction Quality  validated
Protein length 

Sequence

Length: 332  
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0 Synonyms

3 GO Terms

Identifier Name Description
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
GO:0005215 transporter activity Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.

25 Blast

Analysis Hit Start End Strand Length Note Hit Coverage Hit Length Hit Pident E Val Hit Description
blastp_kegg lcl|vvi:100266052 1 331 + 331 Gaps:60 64.76 542 66.38 6e-138 metal transporter Nramp5-like
blastp_kegg lcl|pop:POPTR_0002s08090g 1 331 + 331 Gaps:61 63.77 552 65.62 2e-136 hypothetical protein
blastp_kegg lcl|cit:102625328 1 331 + 331 Gaps:61 62.61 559 65.43 5e-136 metal transporter Nramp5-like
blastp_kegg lcl|cic:CICLE_v10000736mg 1 331 + 331 Gaps:61 62.61 559 65.14 1e-135 hypothetical protein
blastp_kegg lcl|pop:POPTR_0005s20320g 1 331 + 331 Gaps:68 61.34 569 65.04 3e-133 POPTRDRAFT_760947 hypothetical protein
blastp_kegg lcl|mdm:103424089 1 331 + 331 Gaps:64 78.51 442 65.13 3e-133 metal transporter Nramp5-like
blastp_kegg lcl|pvu:PHAVU_009G127900g 1 330 + 330 Gaps:64 64.68 538 65.23 7e-133 hypothetical protein
blastp_kegg lcl|pmum:103319788 1 331 + 331 Gaps:68 63.55 546 65.71 9e-133 metal transporter Nramp5-like
blastp_kegg lcl|pper:PRUPE_ppa003816mg 1 331 + 331 Gaps:68 63.55 546 65.42 2e-132 hypothetical protein
blastp_kegg lcl|tcc:TCM_035174 1 331 + 331 Gaps:60 63.02 557 62.96 3e-132 Nramp transporter
blastp_uniprot_sprot sp|Q8H4H5|NRAM5_ORYSJ 1 331 + 331 Gaps:56 64.87 538 57.88 2e-117 Metal transporter Nramp5 OS Oryza sativa subsp. japonica GN NRAMP5 PE 2 SV 1
blastp_uniprot_sprot sp|Q0D7E4|NRAM1_ORYSJ 1 289 + 289 Gaps:32 54.63 518 61.13 2e-102 Metal transporter Nramp1 OS Oryza sativa subsp. japonica GN NRAMP1 PE 2 SV 1
blastp_uniprot_sprot sp|Q6ZG85|NRAT1_ORYSJ 1 326 + 326 Gaps:60 63.49 545 49.13 3e-88 Metal transporter NRAT1 OS Oryza sativa subsp. japonica GN NRAT1 PE 2 SV 1
blastp_uniprot_sprot sp|Q9S9N8|NRAM6_ARATH 1 330 + 330 Gaps:50 63.38 527 50.60 2e-87 Metal transporter Nramp6 OS Arabidopsis thaliana GN NRAMP6 PE 2 SV 2
blastp_uniprot_sprot sp|Q653V6|NRAM3_ORYSJ 1 331 + 331 Gaps:56 63.09 550 47.55 1e-83 Metal transporter Nramp3 OS Oryza sativa subsp. japonica GN NRAMP3 PE 2 SV 1
blastp_uniprot_sprot sp|Q9SAH8|NRAM1_ARATH 1 289 + 289 Gaps:36 53.20 532 53.00 2e-82 Metal transporter Nramp1 OS Arabidopsis thaliana GN NRAMP1 PE 1 SV 1
blastp_uniprot_sprot sp|Q5QN13|NRAM4_ORYSJ 1 327 + 327 Gaps:56 59.82 550 42.55 4e-71 Metal transporter Nramp4 OS Oryza sativa subsp. japonica GN NRAMP4 PE 2 SV 1
blastp_uniprot_sprot sp|Q8ZSB0|MNTH_NOSS1 4 275 + 272 Gaps:44 59.28 442 35.88 2e-25 Divalent metal cation transporter MntH OS Nostoc sp. (strain PCC 7120 / UTEX 2576) GN mntH PE 3 SV 1
blastp_uniprot_sprot sp|Q92BT1|MNTH_LISIN 4 265 + 262 Gaps:44 56.25 448 35.71 5e-24 Divalent metal cation transporter MntH OS Listeria innocua serovar 6a (strain CLIP 11262) GN mntH PE 3 SV 1
blastp_uniprot_sprot sp|Q89K67|MNTH_BRADU 1 271 + 271 Gaps:44 58.00 450 35.25 9e-24 Divalent metal cation transporter MntH OS Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110) GN mntH PE 3 SV 1
rpsblast_cdd gnl|CDD|179090 1 272 + 272 Gaps:43 59.45 439 36.78 8e-36 PRK00701 PRK00701 manganese transport protein MntH Reviewed.
rpsblast_cdd gnl|CDD|201864 1 243 + 243 Gaps:46 65.11 364 33.33 2e-32 pfam01566 Nramp Natural resistance-associated macrophage protein. The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1 Nramp2 and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+ Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.
rpsblast_cdd gnl|CDD|162246 1 237 + 237 Gaps:43 62.05 390 33.06 2e-25 TIGR01197 nramp NRAMP (natural resistance-associated macrophage protein) metal ion transporters. This model describes the Nramp metal ion transporter family. Historically in mammals these proteins have been functionally characterized as proteins involved in the host pathogen resistance hence the name - NRAMP. At least two isoforms Nramp1 and Nramp2 have been identified. However the exact mechanism of pathogen resistance was unclear until it was demonstrated by expression cloning and electrophysiological techniques that this protein was a metal ion transporter. It was also independently demonstrated that a microcytic anemia (mk) locus in mouse encodes a metal ion transporter (DCT1 or Nramp2). The transporter has a broad range of substrate specificity that include Fe+2 Zn+2 Mn+2 Co+2 Cd+2 Cu+2 Ni+2 and Pb+2. The uptake of these metal ions is coupled to proton symport. Metal ions are essential cofactors in a number of biological process including oxidative phosphorylation gene regulation and metal ion homeostasis. Nramp1 could confer resistance to infection in one of the two ways. (1) The uptake of Fe+2 can produce toxic hydroxyl radicals via Fenton reaction killing the pathogens in phagosomes or (2) Deplete the metal ion pools in the phagosome and deprive the pathogens of metal ions which is critical for its survival.
rpsblast_cdd gnl|CDD|32098 1 273 + 273 Gaps:42 61.78 416 32.30 1e-21 COG1914 MntH Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism].
rpsblast_kog gnl|CDD|36505 1 289 + 289 Gaps:41 58.05 503 35.96 4e-44 KOG1291 KOG1291 KOG1291 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism].

16 Domain Motifs

Analysis Begin End Length Domain Identifier Cross Ref Description Inter Pro
PRINTS 213 232 20 PR00447 "Reactome:REACT_15518" Natural resistance-associated macrophage protein signature IPR001046
PRINTS 181 198 18 PR00447 "Reactome:REACT_15518" Natural resistance-associated macrophage protein signature IPR001046
Phobius 175 196 22 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 1 64 64 PTHR11706:SF33 none none none
Phobius 94 116 23 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
PANTHER 88 289 202 PTHR11706:SF33 none none none
Phobius 248 274 27 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none
Phobius 197 207 11 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 117 174 58 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Phobius 229 247 19 NON_CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. none
Pfam 1 243 243 PF01566 "Reactome:REACT_15518" Natural resistance-associated macrophage protein IPR001046
PANTHER 1 64 64 PTHR11706 "Reactome:REACT_15518";signature_desc=MANGANESE TRANSPORTER none IPR001046
PANTHER 88 289 202 PTHR11706 "Reactome:REACT_15518";signature_desc=MANGANESE TRANSPORTER none IPR001046
Phobius 275 331 57 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 1 93 93 CYTOPLASMIC_DOMAIN none Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. none
Phobius 208 228 21 TRANSMEMBRANE none Region of a membrane-bound protein predicted to be embedded in the membrane. none

4 Localization

Analysis Start End Length
TMHMM 206 228 22
TMHMM 179 201 22
TMHMM 243 265 22
TMHMM 94 116 22

2 Qtllist

Qtl Name Chromosome Name Linkage Group Prox Marker Dist Marker Position QTL Pos One Pos Two Test Type Test Value R 2
Bourran2_2014_nSecLBD_3P Qrob_Chr08 8 s_1BN2OD_551 s_1B5AYF_599 17,17 0 43,51 lod 1,9229 4,4
Bourran2_2014_rEpiBC_3P Qrob_Chr05 5 s_2GDU0O_517 s_1BT8O3_239 25,81 0 55,45 lod 2,2101 5,5

0 Targeting